A Study of GFH375 in Patients With Advanced Solid Tumors With KRAS G12D Mutations

Inclusion Criteria:

1. Subjects must voluntarily agree to participate in the trial and sign a writteninformed consent form.

2. Male or female ≥ 18 years old and ≤75 years old.

3. ECOG performance status of 0-1.

4. With a life expectancy of ≥12 weeks.

5. With histologically or cytologically confirmed advanced or metastatic solid tumorsharboring KRAS G12D mutation.

6. Have at least one measurable lesion according to RECIST1.1, and the phase Ia allowsno measurable lesion.

7. Adequate laboratory parameters during the screening period.

Exclusion Criteria:

1. Active brain metastases.

2. Prior treatment with a KRAS G12D inhibitor.

3. Palliative radiotherapy was completed within 14 days before the first dose.

4. Have poorly controlled or severe cardiovascular disease.

5. Subjects with active hepatitis B or active hepatitis C.

6. Known allergy to the study drug or its components.

7. Pregnant or lactating women.