Kesimpta (Ofatumumab) in Greek Multiple Sclerosis Patients - an Observational Study

Inclusion Criteria:

1. Written IC must be obtained before participating in the study.

2. Patients with diagnosis of RMS per McDonald Criteria (2017) and <5 years since firstMS symptom prior to initiation of ofatumumab.

3. Patients who have been on treatment with ofatumumab for at least 3 months, but notlonger than 6 months prior to inclusion in the study.

4. Ofatumumab treatment in line with the European Product Information of Kesimpta (i.e., adult patients with relapsing forms of MS with active disease defined byclinical or imaging features).

5. Patients with at least one available brain MRI scan performed at least 3 monthsafter ofatumumab initiation OR for whom the physician (as per her/his routinepractice and independently of his/her decision to include the patient in the currentstudy) plans to perform such scanning within 31 days after patient's inclusion inthe study. Notes: This MRI scan can be either brain gadolinium enhanced (Gd+) or not. In caseit is not gadolinium enhanced, the most recent MRI prior to ofatumumab treatmentshould be brain gadolinium enhanced, for relevant comparison and identification ofnew lesions. This MRI scan will serve as the index reference assessment for theevaluation of NEDA-3 radiological component and shall not have been performed within 30 days after the termination of steroid therapy.

6. Patients willing and able to complete the assessments, including PRO questionnaires,as per physicians' clinical practice and as outlined in this study.

Exclusion Criteria:

1. Use of investigational drugs during the study, OR between ofatumumab initiation andinclusion into the study, OR within 3 months before ofatumumab initiation, OR within 5 half-lives of investigational drug before ofatumumab initiation, OR until theexpected pharmacodynamic effect has returned to baseline, whichever is longer.

2. Currently pregnant (or intention to become pregnant within the study period),breastfeeding or lactating women.