Oral Vitamin D Supplementation Prevent Peritoneal Dialysis-related Peritonitis

Inclusion Criteria:

• Medically stable and receiving peritoneal dialysis for > 1 month

• Older than 18 years old

• Serum 25(OH)D < 30ng/ml

• Adequate dialysis on evaluation with weekly Kt/V ≥ 1.5, or (revised time: 2023-7-11)without clinical uremic symptoms

Exclusion Criteria:

• Receive Vitamin D2/D3 during the previous 1 month (revised time: 2023-7-11) ;

• History of allergic reaction to Cholecalciferol;

• Current or past malignant disease, active hepatitis or hepatic failure, activeautoimmune disease, severe digestive malabsorption or an eating disorder, HIV/AIDS;

• Acute systemic infection, cardiovascular disease, surgery, or trauma in the lastmonth;

• A high probability of receiving a kidney transplant or transferring to hemodialysisor drop-out due to socioeconomic causes within 6 months;

• History of kidney transplant;

• Hemodialysis combined with peritoneal dialysis currently;

• Pregnant or breastfeeding;

• Not suitable enrolled assessed by researchers, including patients who could notregular follow-up