A Study of AK104 With Chemotherapy as First-line Treatment in Patients With Advanced Pancreatic Cancer

Inclusion Criteria:

1. Ability to understand and voluntarily sign a written informed consent form (ICF),which must be signed before the specified study procedures required for the studyare performed.

2. Males or females aged ≥ 18 years and ≤ 75 years at the time of signing the ICF.

3. Histologically or cytologically confirmed pancreatic ductal adenocarcinoma (PDAC).

4. Patients have not received prior systemic therapy for locally advanced or metastaticpancreatic cancer; for patients who have received prior induction chemotherapy,concurrent chemoradiotherapy, or adjuvant/neoadjuvant chemotherapy for curativeintent, the time between disease progression and last treatment should be at least 6months.

5. Patients have at least one measurable tumor lesion per RECIST v1.1; lesions thatreceived radiotherapy are not selected as target lesions, unless the lesion is theonly measurable lesion and has unequivocal progression as judged by imaging, it canbe considered as a target lesion.

6. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

7. Expected survival ≥ 3 months.

8. Patients who have adequate organ function.

9. Women of childbearing potential must have a negative serum pregnancy test within 7days prior to the first dose and agree to take effective contraception measuresduring the study drug administration and within 120 days after the last dose. Malepatients with female partners of childbearing potential must agree to take effectivecontraception measures during the study drug administration and within 120 daysafter the last dose.

Exclusion Criteria:

1. Histologically or cytologically confirmed other pathological types, such as acinarcell carcinoma, pancreatic neuroendocrine neoplasms or pancreatoblastoma.

2. Known active or untreated brain metastases, meningeal metastases, spinal cordcompression, or leptomeningeal disease.

3. Patients with known germ line BRAC1/2 mutation.

4. Presence of clinically symptomatic pleural effusion, pericardial effusion, orascites requiring frequent drainage (≥ 1/month).

5. Patients who, in the opinion of the investigator, have symptoms or signs suggestiveof clinically unacceptable deterioration of the primary disease at the time ofscreening.

6. Active malignancies within the past 3 years, with the exception of tumors in thisstudy and cured local tumors.

7. Major surgery other than the diagnosis of pancreatic cancer within 28 days prior tothe first dose or major surgery is expected during the study.

8. Pregnant or lactating women.

9. Patients who received any prior treatments targeting the mechanism of tumorimmunity.

10. Patients with known contraindications to prescribed chemotherapy regimen (seeinstructions for specific drug).

11. Patients with known medical history of severe hypersensitivity reactions to othermonoclonal antibodies or intravenous gamma globulin.

12. Active autoimmune disease within 2 years prior to the start of study treatmen.

13. Known active pulmonary tuberculosis.

14. Patients with active hepatitis B or active hepatitis C.

15. Known medical history of immunodeficiency or positive HIV test.

16. Patients with active infection.

17. Known history of allogeneic organ transplantation and allogeneic hematopoietic stemcell transplantation.

18. Concurrent participation in another clinical study, unless it is an observational,non-interventional clinical study or the follow-up period of an interventionalstudy.

19. Any condition that, in the opinion of the Investigator, may result in a risk whenreceiving the study drug, or would interfere with the evaluation of the study drugor the safety of patients, or the interpretation of the study results.