Investigation of the Immuno-regulation and Viral Hepatitis Among Patients With or After Dengue Fever Infection

Last updated: February 27, 2019
Sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Fever

Treatment

N/A

Clinical Study ID

NCT00688389
KMUH-IRB-960195_1
CB9615
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The study will collect the blood samples from 350 healthy persons and 350 persons infected with dengue fever.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Clinical diagnosis of Dengue fever

Exclusion

Exclusion Criteria:

Study Design

Total Participants: 700
Study Start date:
July 01, 2007
Estimated Completion Date:
December 31, 2020

Study Description

Research has showed that CLEC5A interacts with dengue virion directly, and is responsible for dengue virus (DV)-induced DAP12 phosphorylation. Data suggests that CLEC5A is a potential therapeutic target for dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). This project will study the genes of CLEC5A, Mannose receptor, DC-SIGN, NALP, decoy receptor 3 (DcR3), Toll-like receptors(TLRs), and (Nod)-like receptors (NLRs) for both DF and DHF groups. In addition, serum level of decoy receptor 3 (DcR3) will be tested. The study will collect the blood samples from 350 healthy persons and 350 persons infected with dengue fever.

Connect with a study center

  • Kaoshing Medical University Chung-Ho Memorial Hospital

    Kaohsiung,
    Taiwan

    Active - Recruiting

  • Kaoshing Medical University Chung-Ho Memorial Hospital

    Kaoshiung,
    Taiwan

    Site Not Available

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