Last updated on August 2017

Vincristine Sulfate Liposome Injection (Marqibo ) in Combination With UK ALL R3 Induction Chemotherapy for Children Adolescents and Young Adults With Relapsed ALL


Brief description of study

This is a pilot study utilizing Marqibo® (vincristine sulfate liposome injection) combined with dexamethasone, mitoxantrone and asparaginase (UK ALL R3) for relapsed acute lymphoblastic leukemia (ALL).

Detailed Study Description

This study will utilize Marqibo® as a replacement for standard vincristine in combination with UK ALL R3 induction for children with relapsed ALL. The hypothesis is that the incorporation of Marqibo® with combination chemotherapy will be safe and feasible. In the context of this pilot study, overall outcomes and efficacy will be a secondary objective. It is hypothesized that data from this combination may show improved efficacy including, complete remission (CR), minimal residual disease (MRD) negativity, and progression free survival (PFS) rates and safety (i.e., neurotoxicity) in comparison to outcomes in historical regimens, including the UK ALL R3 with standard vincristine.

Clinical Study Identifier: NCT02879643

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Alan Wayne, MD

Childrens Hospital Los Angeles
Los Angeles, CA United States
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Van Thu Huynh, MD

Children's Hospital Orange County
Orange, CA United States
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Michelle Hermiston, MD

UCSF School of Medicine
San Francisco, CA United States
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Lia Gore, MD

The Children's Hospital, University of Colorado
Aurora, CO United States
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Reuven Schore, MD

Children's National Medical Center
Washington, D.C., United States
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Julio Barredo, MD

University of Miami
Miami, FL United States
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Gregory Hale, MD

All Children's Hospital
Saint Petersburg, FL United States
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Melinda Pauly, MD

Children's Healthcare of Atlanta at Egleston
Atlanta, GA United States
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Nobuko Hijiya, MD

Lurie Children's Hospital of Chicago
Chicago, IL United States
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Patrick Brown, MD

Sidney Kimmel Cancer Center at Johns Hopkins
Baltimore, MD United States
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Nirali Shah, MD

National Cancer Institute, Pediatric Oncology Branch
Bethesda, MD United States
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Lewis Silverman, MD

Dana-Farber Cancer Institute
Boston, MA United States
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Raymond J Hutchinson, MD

CS Mott Children's Hospital, Ann Arbor
Ann Arbor, MI United States
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Yoav Messinger, MD

Children's Hospitals and Clinics of Minnesota
Minneapolis, MN United States
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Maria Luisa Sulis, MD

Children's Hospital New York-Presbyterian
New York, NY United States
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Joel Kaplan, DO

Levine Children's Hospital
Charlotte, NC United States
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Maureen O'Brien, MD

Cincinnati Children's Hospital
Cincinnati, OH United States
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Robin Norris, MD, MS, MPH

Rainbow Babies & Children's Hospital
Cleveland, OH United States
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Robyn Dennis, MD

Nationwide Children's Hospital
Columbus, OH United States
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Bill Chang, MD

Oregon Health & Science University
Portland, OR United States
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Susan Rheingold, MD

Children's Hospital of Philadelphia
Philadelphia, PA United States
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Howard Katzenstein

Monroe Carell Jr. Children's Hospital at Vanderbilt
Nashville, TN United States
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Ted Laetsch, MD

University of Texas Southwestern Medical Center
Dallas, TX United States
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Kenneth Heym, MD

Cook Children's Medical Center
Fort Worth, TX United States
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Eric S Schafer, MD, MHS

Texas Children's Cancer Center, Baylor
Houston, TX United States
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Elizabeth Raetz, MD

Primary Children's Hospital
Salt Lake City, UT United States
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Todd Cooper, MD

Seattle Children's Hospital
Seattle, WA United States
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Mike Burke, MD

Medical College of Wisconsin
Milwaukee, WI United States
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David Ziegler, MD

Sydney Children's Hospital
Randwick, Australia
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Luciano Dalla-Pozza, MD

The Children's Hospital at Westmead
Westmead, Australia
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Chris Fraser, MD

Lady Cilento Children's Hospital
South Brisbane, Australia
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Francoise Mechinaud, MD

Royal Children's Hospital, Melbourne
Parkville,, Australia
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Kirk Schultz, MD

British Columbia Children's Hospital
Vancouver, BC Canada
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Jim Whitlock, MD

Hospital for Sick Children
Toronto, ON Canada
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Henrique Bittencourt, MD

Sainte-Justine University Hospital Center
Montréal, Québec, Canada
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