Last updated on September 2017

Denintuzumab Mafodotin (SGN-CD19A) Combined With RCHOP or RCHP Versus RCHOP Alone in Diffuse Large B-Cell Lymphoma or Follicular Lymphoma


Brief description of study

This is a Phase 2 study to evaluate the combination of denintuzumab mafodotin in combination with RCHOP or RCHP compared with RCHOP alone as front-line therapy in patients with diffuse large B-cell lymphoma or follicular lymphoma Grade 3b.

Detailed Study Description

In Part A of the study, patients will be randomized 1:1 to receive denintuzumab mafodotin plus RCHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) or denintuzumab mafodotin plus RCHP (rituximab, cyclophosphamide, doxorubicin, and prednisone) to assess the safety of these 2 combination regimens. Part B of the study is designed to evaluate the antitumor activity and safety of denintuzumab mafodotin in combination with either RCHOP or RCHP (Experimental Arm) compared with RCHOP alone (Comparator Arm).

Clinical Study Identifier: NCT02855359

.

Contact Investigators or Research Sites near you

Start Over

Please choose location

View all locations

Amitkumar Mehta, MD

University of Alabama at Birmingham
Birmingham, AL United States
  Connect »

Marc Monte, MD

Saint Bernards Cancer Center
Jonesboro, AR United States
  Connect »

Elizabeth Budde, MD

City of Hope
Duarte, CA United States
  Connect »

Haresh Jhangiani, MD

Compassionate Cancer Care Medical Group, Inc.
Fountain Valley, CA United States
  Connect »

Caroline Behler, MD

Pacific Hematology Oncology Associates
San Francisco, CA United States
  Connect »

Visha Rana, MD

University of Colorado Health Memorial Hospital
Colorado Springs, CO United States
  Connect »

Steven Schuster, MD

Poudre Valley Hospital Harmony Campus
Fort Collins, CO United States
  Connect »

Bradley Sumrall, MD

Central Georgia Cancer Care
Macon, GA United States
  Connect »

Scott Smith, MD

Loyola University Medical Center
Maywood, IL United States
  Connect »

Umar Farooq, MD

University of Iowa Hospitals and Clinics
Iowa City, IA United States
  Connect »

Don Stevens, MD

Norton Cancer Institute
Louisville, KY United States
  Connect »

Muhammed-Ali Zaydan, MD

Montgomery Cancer Center
Mount Sterling, KY United States
  Connect »

Nakhle Saba, MD

Tulane University Hospital and Clinic
New Orleans, LA United States
  Connect »

Sumana Devata, MD

University of Michigan Comprehensive Cancer Center
Ann Arbor, MI United States
  Connect »

Michaela Tsai, MD

Virginia Piper Cancer Institute
Minneapolis, MN United States
  Connect »

John Hrom, MD

Hattiesburg Clinic (Forrest General Hospital)
Hattiesburg, MS United States
  Connect »

Suman Kambhampati, MD

Research Medical Center
Kansas City, MO United States
  Connect »

Sadar Imam, MD

San Juan Oncology Associates
Farmington, NM United States
  Connect »

Joshua Brody, MD

Mount Sinai Hospital
New York, NY United States
  Connect »

Murali Janakiram, MD

Montefiore Medical Center - Bronx
The Bronx, NY United States
  Connect »

Matthew McKinney, MD

Duke University Medical Center
Durham, NC United States
  Connect »

Keith Lerro, MD

Regional Medical Oncology Center
Wilson, NC United States
  Connect »

Nashat Gabrail, MD

Gabrail Cancer Center Research
Canton, OH United States
  Connect »

Paolo Caimi, MD

University Hospitals Seidman Cancer Center
Cleveland, OH United States
  Connect »

Onder Alpdogan, MD

Thomas Jefferson University Hospital
Philadelphia, PA United States
  Connect »

Jing-Zhou Hou, MD

University of Pittsburgh Medical Center
Pittsburgh, PA United States
  Connect »

Valeriy Sedov, MD

Hollings Cancer Center
Charleston, SC United States
  Connect »

Ian Flinn, MD

Tennessee Oncology / Sarah Cannon Research Institute
Nashville, TN United States
  Connect »

Moshe Yair Levy, MD

Baylor Health - Baylor University Medical Center
Dallas, TX United States
  Connect »

Donald Quick, MD

Joe Arrington Cancer Research and Treatment Center
Lubbock, TX United States
  Connect »

Vinit Karur, MD

Scott and White Memorial Hospital - Temple
Temple, TX United States
  Connect »

Ying Zhou, MD

Kadlec Clinic Hematology and Oncology
Kennewick, WA United States
  Connect »

Joseph Ye, MD

Vista Oncology INC PS
Olympia, WA United States
  Connect »

Jorge Chaves, MD

Northwest Medical Specialties, PLLC
Tacoma, WA United States
  Connect »

Anna DiMarco, MD

Ponce Medical School Foundation
Ponce, Puerto Rico
  Connect »