Last updated on September 2017

Denintuzumab Mafodotin (SGN-CD19A) Combined With RCHOP or RCHP Versus RCHOP Alone in Diffuse Large B-Cell Lymphoma or Follicular Lymphoma

Brief description of study

This is a Phase 2 study to evaluate the combination of denintuzumab mafodotin in combination with RCHOP or RCHP compared with RCHOP alone as front-line therapy in patients with diffuse large B-cell lymphoma or follicular lymphoma Grade 3b.

Detailed Study Description

In Part A of the study, patients will be randomized 1:1 to receive denintuzumab mafodotin plus RCHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) or denintuzumab mafodotin plus RCHP (rituximab, cyclophosphamide, doxorubicin, and prednisone) to assess the safety of these 2 combination regimens. Part B of the study is designed to evaluate the antitumor activity and safety of denintuzumab mafodotin in combination with either RCHOP or RCHP (Experimental Arm) compared with RCHOP alone (Comparator Arm).

Clinical Study Identifier: NCT02855359

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Amitkumar Mehta, MD

University of Alabama at Birmingham
Birmingham, AL United States
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Marc Monte, MD

Saint Bernards Cancer Center
Jonesboro, AR United States
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Elizabeth Budde, MD

City of Hope
Duarte, CA United States
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Haresh Jhangiani, MD

Compassionate Cancer Care Medical Group, Inc.
Fountain Valley, CA United States
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Caroline Behler, MD

Pacific Hematology Oncology Associates
San Francisco, CA United States
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Visha Rana, MD

University of Colorado Health Memorial Hospital
Colorado Springs, CO United States
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Steven Schuster, MD

Poudre Valley Hospital Harmony Campus
Fort Collins, CO United States
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Bradley Sumrall, MD

Central Georgia Cancer Care
Macon, GA United States
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Scott Smith, MD

Loyola University Medical Center
Maywood, IL United States
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Umar Farooq, MD

University of Iowa Hospitals and Clinics
Iowa City, IA United States
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Don Stevens, MD

Norton Cancer Institute
Louisville, KY United States
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Muhammed-Ali Zaydan, MD

Montgomery Cancer Center
Mount Sterling, KY United States
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Nakhle Saba, MD

Tulane University Hospital and Clinic
New Orleans, LA United States
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Sumana Devata, MD

University of Michigan Comprehensive Cancer Center
Ann Arbor, MI United States
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Michaela Tsai, MD

Virginia Piper Cancer Institute
Minneapolis, MN United States
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John Hrom, MD

Hattiesburg Clinic (Forrest General Hospital)
Hattiesburg, MS United States
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Suman Kambhampati, MD

Research Medical Center
Kansas City, MO United States
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Sadar Imam, MD

San Juan Oncology Associates
Farmington, NM United States
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Joshua Brody, MD

Mount Sinai Hospital
New York, NY United States
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Murali Janakiram, MD

Montefiore Medical Center - Bronx
The Bronx, NY United States
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Matthew McKinney, MD

Duke University Medical Center
Durham, NC United States
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Keith Lerro, MD

Regional Medical Oncology Center
Wilson, NC United States
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Nashat Gabrail, MD

Gabrail Cancer Center Research
Canton, OH United States
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Paolo Caimi, MD

University Hospitals Seidman Cancer Center
Cleveland, OH United States
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Onder Alpdogan, MD

Thomas Jefferson University Hospital
Philadelphia, PA United States
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Jing-Zhou Hou, MD

University of Pittsburgh Medical Center
Pittsburgh, PA United States
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Valeriy Sedov, MD

Hollings Cancer Center
Charleston, SC United States
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Ian Flinn, MD

Tennessee Oncology / Sarah Cannon Research Institute
Nashville, TN United States
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Moshe Yair Levy, MD

Baylor Health - Baylor University Medical Center
Dallas, TX United States
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Donald Quick, MD

Joe Arrington Cancer Research and Treatment Center
Lubbock, TX United States
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Vinit Karur, MD

Scott and White Memorial Hospital - Temple
Temple, TX United States
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Ying Zhou, MD

Kadlec Clinic Hematology and Oncology
Kennewick, WA United States
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Joseph Ye, MD

Vista Oncology INC PS
Olympia, WA United States
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Jorge Chaves, MD

Northwest Medical Specialties, PLLC
Tacoma, WA United States
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Anna DiMarco, MD

Ponce Medical School Foundation
Ponce, Puerto Rico
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