Last updated on October 2017

Study Comparing Efficacy and Safety of Defibrotide vs Best Supportive Care in the Prevention of Hepatic Veno-Occlusive Disease in Adult and Pediatric Patients


Brief description of study

This study is to compare the efficacy and safety of defibrotide prophylaxis in addition to best supportive care versus best supportive care alone in the prevention of hepatic veno- occlusive disease (VOD) in adult and pediatric patients undergoing hematopoietic stem cell transplant who are at high risk or very high risk of developing VOD.

Clinical Study Identifier: NCT02851407

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Emmanuel Katsanis, MD

University of Arizona Cancer Center
Tucson, AZ United States
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Rajni Agarwal-Hashmi

Stanford University
Palo Alto, CA United States
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Eric Anderson

Rady Childrens Hospital San Diego
San Diego, CA United States
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Alexis Melton

University of California San Francisco
San Francisco, CA United States
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Roger Giller

Colorado Children's Hospital
Aurora, CO United States
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Emi Caywood, MD

Alfred I Dupont Hospital For Children
Wilmington, DE United States
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Kamar Godder

Nicklaus Childrens Hospital
Miami, FL United States
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Shahram Mori

Florida Hospital Cancer Institute
Orlando, FL United States
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Ben Oshrine

Johns Hopkins All Children's Hospital
Saint Petersburg, FL United States
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Elizabeth Stenger

Children's Healthcare of Atlanta
Atlanta, GA United States
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Reggie Duerst

Ann and Robert H Lurie Childrens Hospital of Chicago
Chicago, IL United States
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Jason Law, MD

Tufts Floating Hospital for Children
Boston, MA United States
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Sureyya Savasan

Children's Hospital of Michigan
Detroit, MI United States
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Mohamed Radhi

Children's Mercy Hospital
Kansas City, MO United States
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Monica Bhatia

Columbia University Medical Center
New York, NY United States
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Sajad Khazal, MBChB

Children's Hospital at Montefiore
The Bronx, NY United States
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Paul Martin

Duke University Medical Center
Durham, NC United States
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Jihnesh Dalal

University Hospitals Case Medical Center
Cleveland, OH United States
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Rabi Hanna

Cleveland Clinic
Cleveland, OH United States
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Rajinder Bajwa

Nationwide Children's Hospital
Columbus, OH United States
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Eneida Nemecek

Doernbecher Children's Hospital
Portland, OR United States
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Robert Greiner, MD

Penn State Milton S Hershey Medical Center
Hershey, PA United States
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Stephan Grupp

Children's Hospital of Philadelphia
Philadelphia, PA United States
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Michelle Hudspeth

Medical University of South Carolina - PPDS
Charleston, SC United States
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Renee Madden

St. Jude Children's Research Hospital
Memphis, TN United States
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Carrie Kitko

Vanderbilt Ingram Cancer Center
Nashville, TN United States
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Tiffany Simms-Waldrip

Children's Medical Center Dallas
Dallas, TX United States
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Meaghan Granger

Cook Childrens Hospital
Fort Worth, TX United States
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Robert Krance

Texas Childrens Hospital
Houston, TX United States
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Troy Quigg, DO

Methodist Children's Hospital
San Antonio, TX United States
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Ann Woolfrey

Fred Hutchinson Cancer Research Center
Seattle, WA United States
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Devendra Hiwase

Royal Adelaide Hospital
Adelaide, Australia
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Seong Lin Khaw

Royal Children's Hospital Melbourne
Melbourne, Australia
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Xavier Poire

Cliniques Universitaires Saint-Luc
Bruxelles, Belgium
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Tessa Kerre

UZ Gent
Gent, Belgium
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Evelyne Williams

Centre Hospitalier Universitaire du Sart Tilman
Liege, Belgium
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Sylvie Francois

CHU Angers
Angers, France
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Ana Berceanu

Hopital Jean Minjoz
Besançon, France
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Didier Blaise

Institut Paoli Calmettes
Marseille, France
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Mohamad Mohty

H pital Saint Antoine
Paris, France
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Jean-Hugues Dalle

H pital Robert Debr
Paris, France
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Natacha Maillard

CHU de Poitiers
Poitiers, France
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Anne Huynh

Institut Universitaire du Cancer de Toulouse - Oncop le
Toulouse, France
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Martin Kaufmann

Abteilung f r H matologie Onkologie und Palliativmedizin
Stuttgart, Germany
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Olaf Hopfer

Klinikum Frankfurt Oder GmbH
Frankfurt (Oder), Germany
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Udo Kontny

Universit tsklinikum der RWTH Aachen
Aachen, Germany
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Matthias Stelljes

Universit tsklinikum M nster
Münster, Germany
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Friedrich Stolzel

Universit tsklinikum Carl Gustav Carus an der TU Dresden
Dresden, Germany
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Dietger Niederwieser

Universit tsklinikum Leipzig
Leipzig, Germany
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Igor Blau

Charit Universit tsmedizin Berlin
Berlin, Germany
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Christine Wolschke

Universit tsklinikum Hamburg Eppendorf
Hamburg, Germany
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Irina Zaidman

Rambam Health Care Campus
Haifa, Israel
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Tsila Zuckerman

Rambam Health Corporation
Haifa, Israel
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Paulina Stepensky

Hadassah Ein Kerem Hospital
Jerusalem, Israel
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