Last updated on October 2017

A Study to Evaluate the Safety and Efficacy of ABT-494 for Induction and Maintenance Therapy in Subjects With Moderately to Severely Active Ulcerative Colitis


Brief description of study

This study comprises three sub-studies. The objective of sub-study 1 is to characterize the dose-response, efficacy, and safety of ABT-494 compared to placebo in inducing clinical remission in order to identify the induction dose of ABT-494 for further evaluation in sub-study 2. The objective of sub-study 2 is to evaluate the efficacy and safety of ABT-494 compared to placebo in inducing clinical remission in participants. The objective of sub-study 3 is to evaluate the efficacy and safety of ABT-494 compared to placebo in achieving clinical remission in participants who had a response following induction with ABT-494.

Clinical Study Identifier: NCT02819635

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Guri-si, Gyeonggi-do, Korea, Republic of
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St. Vincent's Hospital /ID# 150347
Paldal-gu, Suwon,Gyeonggi-do, Korea, Republic of
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Kangbuk Samsung Hospital /ID# 150348
Seoul, Korea, Republic of
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Severance Hospital /ID# 159478
Seoul, Korea, Republic of
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Asan Medical Center /ID# 150900
Seoul, Korea, Republic of
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Samsung Medical Center /ID# 150346
Seoul, Korea, Republic of
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Pauls Stradins Clinical University Hospital /ID# 151409
Riga, Latvia
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Riga East Clinical University Hospital /ID# 150354
Riga, Latvia
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Klaipeda University Hospital /ID# 158862
Klaipeda, Lithuania
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Hospital Sultanah Bahiyah /ID# 151687
Alor Setar, Malaysia
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Hospital Ampang /ID# 151298
Ampang, Selangor Darul Ehsan, Malaysia
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Universiti Kebangsaan Malaysia Medical Centre /ID# 151689
Cheras, Kuala Lumpur, Malaysia
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University of Malaya Medical Centre /ID# 150359
Kuala Lumpur, Wilayah Persekut, Malaysia
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Academisch Medisch Centrum /ID# 150647
Amsterdam, Netherlands
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Leids Universitair Medisch Centrum /ID# 152624
Leiden, Netherlands
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UMC St. Radboud /ID# 151700
Nijmegen, Netherlands
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Erasmus Medisch Centrum /ID# 150308
Rotterdam, Netherlands
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UMC Utrecht /ID# 152775
Utrecht, Netherlands
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Akershus Universitetssykehus /ID# 150317
Nordbyhagen, Norway
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Oslo University Hospital (OUS) /ID# 150856
Oslo, Norway
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Universitetssykehuset Nord-Norge HF /ID# 152835
Tromso, Norway
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Endoskopia Sp. z o.o. /ID# 150765
Sopot, Poland
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Centrum Zdrowia Matki Dziecka I Mlodziezy /ID# 150351
Warsaw, Poland
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Zespol Przychodni Specjalistycznych Prima Sp. Z O.O. /Id# 150580
Warsaw, Poland
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Hospital Garcia de Orta, E.P.E /ID# 151613
Almada, Portugal
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Hospital de Braga /ID# 151608
Braga, Portugal
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Hospital Senhora Da Oliveira Gulmaraes, EPE /ID# 151607
Guimaraes, Portugal
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Centro Hospitalar de Lisboa Central, EPE /ID# 151611
Lisboa, Portugal
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Centro Hospitalar de Lisbon Norte, EPE /ID# 151606
Lisbon, Portugal
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Centro Hospitalar de Sao Joao, E.P.E.(CHSJ-HSJ) /ID# 151610
Porto, Portugal
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Centro Hospitalar de Entre o Douro e Vouga, EPE /ID# 152335
Santa Maria da Feira, Portugal
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Unidade Local De Saude Do Alto Minho, EPE /ID# 151609
Viana Do Castelo, Portugal
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University of Puerto Rico, School of Medicine /ID# 150358
San Juan, Puerto Rico
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"Institutul Clinic Fundeni Centrul de Gastroenterologie si H /ID# 150368
Bucharest, Romania
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"Institutul Clinic Fundeni Centrul de Gastroenterologie si H /ID# 150983
Bucharest, Romania
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Cabinet Particular Policlinic Algomed SRL /ID# 150369
Timisoara, Romania
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City Clinical Hospital 24 /ID# 150395
Moscow, Russian Federation
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P.A. Bayandin Murmansk Regional Clinical Hospital /ID# 165915
Murmansk, Russian Federation
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Perm Clinical Center of FMBA /ID# 150386
Perm, Russian Federation
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Stavropol State Medical University /ID# 150387
Stavropol, Russian Federation
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Clinical Center of Serbia /ID# 150428
Belgrade,, Serbia
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Clinical Hospital Center Bezanijska Kosa /ID# 150426
Belgrade, Serbia
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Clinical Hospital Center Zvezdara /ID# 150427
Belgrade, Serbia
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Clinical Hospital Centre Zemun /ID# 150763
Belgrade, Serbia
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Clinical Center Kragujevac /ID# 150430
Kragujevac, Serbia
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Clinical Center of Nis /ID# 151903
Nis, Serbia
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Clinical Center Vojvodina /ID# 150764
Novi Sad, Serbia
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National University Hospital /ID# 150453
Singapore, Singapore
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Tan Tock Seng Hospital /ID# 150443
Singapore, Singapore
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Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bys /ID# 150868
Banska Bystrica, Slovakia
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Medak s.r.o., gastroenterologicka ambulancia /ID# 150480
Bratislava, Slovakia
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Slovak Research Center Team Member /ID# 150257
Ilava, Slovakia
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B and B MED s.r.o. /ID# 150471
Kosice, Slovakia
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Gastro I.S.R.O. /ID# 150472
Presov, Slovakia
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Kingsbury Hospital /ID# 150497
Cape Town, South Africa
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Mediclinic Constantiaberg /ID# 155144
Cape Town, South Africa
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Chris Hani Baragwanath Academic Hospital /ID# 150785
Soweto, Johannesburg, South Africa
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Magtarmmottagningen /ID# 151496
Gothenburg, Sweden
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Universitaetsspital Basel /ID# 161731
Basel, Switzerland
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Inselspital Bern /ID# 152590
Bern, Switzerland
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Kantonsspital St. Gallen /ID# 152599
Gallen, Switzerland
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Universitaetsspital Zurich /ID# 152591
Zurich, Switzerland
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Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 150575
Kaohsiung, Taiwan
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China Medical University Hospital /ID# 150571
Taichung City, Taiwan
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Chung Shan Medical University /ID# 150573
Taichung, Taiwan
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National Cheng Kung University Hospital /ID# 151749
Tainan, Taiwan
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National Taiwan University Hospital /ID# 150574
Taipei 100, Taiwan
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Taipei Veterans General Hospital /ID# 151748
Taipei City, Taiwan
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Kyiv Municipal Clinical Hospital #18 /ID# 150372
Kyiv, Ukraine
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Communal Institution Odesa Regional Clinical Hospital /ID# 151275
Odesa, Ukraine
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Basingstoke & North Hampshire Hospitel /ID# 150380
Basingstoke, United Kingdom
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Royal United Hospitals Bath NHS Foundation Trust /ID# 151532
Bath, United Kingdom
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RD&E Hospital /ID# 150379
Exeter, United Kingdom
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The Royal London Hospital /ID# 150384
London, United Kingdom
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