Last updated on February 2018

Optimizing the Management of Acute Diarrhoeal Disease

Brief description of study

Many children admitted to hospital in Botswana without bloody diarrhoea are presumed to have viral gastroenteritis and so not treated with antibiotics - but they may indeed have a treatable cause for their illness. The investigators will conduct a randomized trial to see if rapid testing using novel methods to identify potentially treatable causes of diarrhoea leads to improved outcomes. The investigators will also be randomizing children to Lactobacillus reuteri DSM (daughter strain) 17938 therapy versus placebo (the standard of care) to see if this treatment decreases the duration of diarrhoea. The proposed study is a large multi-centre trial following the previous pilot trial.

Clinical Study Identifier: NCT02803827

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Tonya Arscott-Mills

Princess Marina Hospital
Gaborone, Botswana
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Banno Moorad

Deborah Retief Hospital
Mochudi, Botswana
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Boswa Ndulamo

Scottish Livingstone Hospital
Molepolole, Botswana
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Banno Moorad

Bamalete Lutheran Hospital
Ramotswa, Botswana
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