Last updated on May 2018

Safety and Efficacy Study of NP001 in Patients With Amyotrophic Lateral Sclerosis (ALS) and Systemic Inflammation


Brief description of study

This study evaluates NP001 in patients with amyotrophic lateral sclerosis (ALS) and evidence of systemic inflammation. Half of participants will receive NP001 and the other half will receive placebo.

Detailed Study Description

This is a randomized, double-blind, placebo-controlled study of NP001 in subjects with ALS and evidence of elevated systemic inflammation. Subjects will be allocated (1:1) to NP001 and placebo. Drug or placebo will be given intravenously.

Clinical Study Identifier: NCT02794857

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Shafeeq Ladha, MD

St. Joseph's Hospital and Medical Center - Barrow Neurology Clinics
Phoenix, AZ United States

Mark Ross, MD

Mayo Clinic Arizona
Scottsdale, AZ United States

Richard Lewis, MD

Cedars-Sinai Medical Center
Los Angeles, CA United States

Namita Goyal, MD

University of California, Irvine, Department of Neurology
Orange, CA United States

Jonathan S. Katz, MD

Forbes Norris MDA/ALS Research Center, CPMC
San Francisco, CA United States

Bjorn E. Oskarsson, MD

Mayo Clinic Florida
Jacksonville, FL United States

Michael Benatar, MD

University of Miami Miller School of Medicine
Miami, FL United States

Christina Fournier, MD

Emory University, Department of Neurology
Atlanta, GA United States

Richard J. Barohn, MD

University of Kansas Medical Center
Kansas City, KS United States

Edward J. Kasarskis, MD, PhD

University of Kentucky, Albert B. Chandler Medical Center
Lexington, KY United States

James Berry, MD, MPH

Massachusetts General Hospital
Boston, MA United States

Georgios Manousakis, MD

Clinical & Translational Science Institute, University of Minnesota
Minneapolis, MN United States

Benjamin Brooks, MD

Carolinas Medical Center, Neurosciences Instutite-Neurology
Charlotte, NC United States

Richard Bedlack, MD, PhD, MS

Duke Neurological Disorders Clinic at Morreene Road
Durham, NC United States

Erik P. Pioro, MD, PhD

Cleveland Clinic Foundation-Cleveland Clinic Hospital
Cleveland, OH United States

Kimberly Goslin, MD, PhD

Providence Brain & Spine Institute, ALS Center
Portland, OR United States

Ericka Simpson, MD

Houston Methodist Neurological Institute
Houston, TX United States

Angela Genge, MD

Montreal Neurological Institute
Montreal, QC Canada