Last updated on June 2018

Multicenter Automatic Defibrillator Implantation Trial With Subcutaneous Implantable Cardioverter Defibrillator

Brief description of study

The MADIT S-ICD trial is designed to evaluate if subjects with a prior myocardial infarction, diabetes mellitus and a relatively preserved ejection fraction of 36-50% will have a survival benefit from receiving a subcutaneous implantable cardioverter defibrillator (S-ICD) when compared to those receiving conventional medical therapy.

Detailed Study Description

In this study, subjects will be randomized to receive a subcutaneous implantable cardioverter defibrillator or Conventional Medical Therapy (CMT). Randomization will be stratified by enrolling site, in a 2:1 (S-ICD:CMT) scheme. Length of follow-up for each subject will be dependent on the date of entry into the study, since all subjects will be followed to a common study termination date.

Clinical Study Identifier: NCT02787785

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Jay Dinerman, MD

Heart Center Research, LLC.
Huntsville, AL United States
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Mayer Rashtian, MD

Huntington Hospital
Pasadena, CA United States
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Mikhael ElChami, MD

Emory University
Atlanta, GA United States
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Michael Giudici, MD

University of Iowa
Iowa City, IA United States
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Brad Sutton, MD

University of Louisville
Louisville, KY United States
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Claudio Schuger, MD

Henry Ford Hospital
Detroit, MI United States
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Peter Gallagher, MD

Nebraska Heart Institute
Lincoln, NE United States
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David Huang, MD

Strong Memorial / University of Rochester Medical Center
Rochester, NY United States
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Raul Weiss, MD

Ohio State Wexner Medical Center
Columbus, OH United States
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Johan Aasbo, MD

Promedica Toledo Hospital
Toledo, OH United States
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Vadim Levin, MD

Phoenixville Hospital
Phoenixville, PA United States
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Khashayar Hematpour, MD

University of Texas, Houston
Houston, TX United States
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Allen Ciuffo, MD

Sentara Norfolk General
Norfolk, VA United States
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Rahul Doshi, MD

University of Southern California
Los Angeles, CA United States
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Paul Ludmer, MD

Alta Bates Summit Hospital
Oakland, CA United States
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S. Scott Wiggins, MD

Advanced Cardiovascular Specialists
Shreveport, LA United States
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Brian Ramza, MD

Saint Luke's Hospital
Kansas City, MO United States
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Jamie Kim, MD

Catholic Medical Center
Manchester, NH United States
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Stavros Mountantonakis

Northwell Health
Manhasset, NY United States
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Sameh Mobarek, MD

North Carolina Heart and Vascular
Raleigh, NC United States
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Nagesh Chopra, MD

Ohio Health Research Institute
Columbus, OH United States
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Harish Manyam, MD

Erlanger Medical Center
Chattanooga, TN United States
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Anthonie Tuinenburg, MD

UMC Utrecht
Utrecht, Netherlands
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Reinoud Knops, MD

Academisch Medisch Centrum
Amsterdam, Netherlands
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Smit Vasaiwala , MD

Loyola University Medical Center
Maywood, IL United States
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George Mark, MD

Cardiovascular Associates of Delaware Valley
Haddon Heights, NJ United States
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Charles Gottlieb, MD

Abington Memorial Hospital
Abington, PA United States
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Samir Saba, MD

University of Pittsburgh Medical Center - Presbyterian
Pittsburgh, PA United States
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Kenneth Ellenbogen, MD

Virginia Commonwealth University
Richmond, VA United States
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Jordan Prutkin, MD

University of Washington
Seattle, WA United States
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Jonathan Lowy, MD

PeaceHealth Southwest Medical Center
Vancouver, WA United States
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Corrina Lenz

Unfallkrankenhaus Berlin
Berlin, Germany
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Nils Gosau

Universitaetsklinik Eppendorf
Hamburg, Germany
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Moshe Swissa , MD

Kaplan Medical Center
Rechovot, Israel
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Raphael Rosso , MD

Tel Aviv Sourasky Medical Center
Tel Aviv, Israel
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Ignacio Garcia Bolao , MD

University of Navarra, Department of Cardiology
Pamplona, Spain
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Luis Scott, MD

Mayo Clinic- Scottsdale
Scottsdale, AZ United States
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John McKenzie III, MD

Glendale Adventist Medical Center
Glendale, CA United States
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Maurizio Lunati , MD

Azienda Ospedaliera Ospedale Niguarda CA Granda
Milano, Italy
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Devi Nair, MD

St. Bernard's Medical Center
Jonesboro, AR United States
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Christopher Madias, MD

Tufts Medical Center
Boston, MA United States
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Christian Veltmann, MD

Medizinische Hochschule Hannover
Hannöver, Germany
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Giovanni Morani, MD

Azienda Ospedaliera Universitaria
Verona, Italy
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Naiara Calvo, MD

Hospital Universitario Miguel Servet
Zaragosa, Spain
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Jan Steffel, MD

University Hospital Zurich
Zürich, Switzerland
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