Last updated on October 2017

Multicenter Automatic Defibrillator Implantation Trial With Subcutaneous Implantable Cardioverter Defibrillator

Brief description of study

The MADIT S-ICD trial is designed to evaluate if subjects with a prior myocardial infarction, diabetes mellitus and a relatively preserved ejection fraction of 36-50% will have a survival benefit from receiving a subcutaneous implantable cardioverter defibrillator (S-ICD) when compared to those receiving conventional medical therapy.

Detailed Study Description

In this study, subjects will be randomized to receive a subcutaneous implantable cardioverter defibrillator or Conventional Medical Therapy (CMT). Randomization will be stratified by enrolling site, in a 2:1 (S-ICD:CMT) scheme. Length of follow-up for each subject will be dependent on the date of entry into the study, since all subjects will be followed to a common study termination date.

Clinical Study Identifier: NCT02787785

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Jay Dinerman, MD

Heart Center Research, LLC.
Huntsville, AL United States
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Paul Ludmer, MD

Alta Bates Summit
Oakland, CA United States
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Mayer Rashtian, MD

Huntington Hospital
Pasadena, CA United States
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Paige Smith, RN

Emory University
Atlanta, GA United States
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Michael Giudici, MD

University of Iowa
Iowa City, IA United States
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Brad Sutton, MD

University of Louisville
Louisville, KY United States
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Claudio Schuger, MD

Henry Ford Hospital
Detroit, MI United States
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Peter Gallagher, MD

Nebraska Heart Institute
Lincoln, NE United States
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David Huang, MD

Strong Memorial / University of Rochester Medical Center
Rochester, NY United States
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Raul Weiss, MD

Ohio State Wexner Medical Center
Columbus, OH United States
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Nagesh Chopra, MD

Ohio Health Reearch Institute
Columbus, OH United States
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Johan Aasbo, MD

Promedica Toledo Hospital
Toledo, OH United States
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Vadim Levin, MD

Phoenixville Hospital
Phoenixville, PA United States
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Khashayar Hematpour, MD

University of Texas, Houston
Houston, TX United States
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Allen Ciuffo, MD

Sentara Norfolk General
Norfolk, VA United States
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Christian Veltmann, MD

Medizinische Hochschule Hannover
Hannöver, Germany
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