Last updated on September 2018

Multicenter Automatic Defibrillator Implantation Trial With Subcutaneous Implantable Cardioverter Defibrillator

Brief description of study

The MADIT S-ICD trial is designed to evaluate if subjects with a prior myocardial infarction, diabetes mellitus and a relatively preserved ejection fraction of 36-50% will have a survival benefit from receiving a subcutaneous implantable cardioverter defibrillator (S-ICD) when compared to those receiving conventional medical therapy.

Detailed Study Description

In this study, subjects will be randomized to receive a subcutaneous implantable cardioverter defibrillator or Conventional Medical Therapy (CMT). Randomization will be stratified by enrolling site, in a 2:1 (S-ICD:CMT) scheme. Length of follow-up for each subject will be dependent on the date of entry into the study, since all subjects will be followed to a common study termination date.

Clinical Study Identifier: NCT02787785

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Jay Dinerman, MD

Heart Center Research, LLC.
Huntsville, AL United States

Mayer Rashtian, MD

Huntington Hospital
Pasadena, CA United States

Mikhael ElChami, MD

Emory University
Atlanta, GA United States

Michael Giudici, MD

University of Iowa
Iowa City, IA United States

Brad Sutton, MD

University of Louisville
Louisville, KY United States

Claudio Schuger, MD

Henry Ford Hospital
Detroit, MI United States

Peter Gallagher, MD

Nebraska Heart Institute
Lincoln, NE United States

David Huang, MD

Strong Memorial / University of Rochester Medical Center
Rochester, NY United States

Raul Weiss, MD

Ohio State Wexner Medical Center
Columbus, OH United States

Johan Aasbo, MD

Promedica Toledo Hospital
Toledo, OH United States

Vadim Levin, MD

Phoenixville Hospital
Phoenixville, PA United States

Khashayar Hematpour, MD

University of Texas, Houston
Houston, TX United States

Allen Ciuffo, MD

Sentara Norfolk General
Norfolk, VA United States

Rahul Doshi, MD

University of Southern California
Los Angeles, CA United States

Paul Ludmer, MD

Alta Bates Summit Hospital
Oakland, CA United States

S. Scott Wiggins, MD

Advanced Cardiovascular Specialists
Shreveport, LA United States

Brian Ramza, MD

Saint Luke's Hospital
Kansas City, MO United States

Jamie Kim, MD

Catholic Medical Center
Manchester, NH United States

Stavros Mountantonakis

Northwell Health
Manhasset, NY United States

Sameh Mobarek, MD

North Carolina Heart and Vascular
Raleigh, NC United States

Nagesh Chopra, MD

Ohio Health Research Institute
Columbus, OH United States

Harish Manyam, MD

Erlanger Medical Center
Chattanooga, TN United States

Anthonie Tuinenburg, MD

UMC Utrecht
Utrecht, Netherlands

Reinoud Knops, MD

Academisch Medisch Centrum
Amsterdam, Netherlands

Smit Vasaiwala , MD

Loyola University Medical Center
Maywood, IL United States

George Mark, MD

Cardiovascular Associates of Delaware Valley
Haddon Heights, NJ United States

Charles Gottlieb, MD

Abington Memorial Hospital
Abington, PA United States

Samir Saba, MD

University of Pittsburgh Medical Center - Presbyterian
Pittsburgh, PA United States

Kenneth Ellenbogen, MD

Virginia Commonwealth University
Richmond, VA United States

Jordan Prutkin, MD

University of Washington
Seattle, WA United States

Jonathan Lowy, MD

PeaceHealth Southwest Medical Center
Vancouver, WA United States

Corrina Lenz

Unfallkrankenhaus Berlin
Berlin, Germany

Nils Gosau

Universitaetsklinik Eppendorf
Hamburg, Germany

Moshe Swissa , MD

Kaplan Medical Center
Rechovot, Israel

Raphael Rosso , MD

Tel Aviv Sourasky Medical Center
Tel Aviv, Israel

Ignacio Garcia Bolao , MD

University of Navarra, Department of Cardiology
Pamplona, Spain

Luis Scott, MD

Mayo Clinic- Scottsdale
Scottsdale, AZ United States

John McKenzie III, MD

Glendale Adventist Medical Center
Glendale, CA United States

Maurizio Lunati , MD

Azienda Ospedaliera Ospedale Niguarda CA Granda
Milano, Italy

Devi Nair, MD

St. Bernard's Medical Center
Jonesboro, AR United States

Christopher Madias, MD

Tufts Medical Center
Boston, MA United States

Christian Veltmann, MD

Medizinische Hochschule Hannover
Hannöver, Germany

Giovanni Morani, MD

Azienda Ospedaliera Universitaria
Verona, Italy

Naiara Calvo, MD

Hospital Universitario Miguel Servet
Zaragosa, Spain

Jan Steffel, MD

University Hospital Zurich
Zürich, Switzerland