Last updated on August 2018

Study of PRO 140 for Prophylaxis of Acute GVHD in Patients Undergoing RIC Allogenic Stem-Cell Transplantaton


Brief description of study

This is an Open-Label, Single-Arm, Phase II Multicenter Study of the Safety and Efficacy of PRO 140 for Prophylaxis of Acute Graft-Versus-Host Disease (GVHD) in Patients Undergoing Reduced Intensity Conditioning (RIC) Allogeneic Stem-Cell Transplantation.

Detailed Study Description

This is an open-label, single-arm, phase II, multicenter study to evaluate the feasibility of the use of PRO 140 as an add-on therapy to standard GVHD prophylaxis treatment for prevention of acute GVHD in adult patients undergoing RIC allogeneic HCT.

In this study, up to 60 subjects will be enrolled. PRO 140 will be administered as a 525 mg subcutaneous injection on Day -3 or Day -2 prior to stem cell infusion, on the day of stem cell infusion (Day 0), and then weekly for up to 1007 days. Subjects will return to the clinic for three Follow-up visits at 2 weeks after the last treatment visit, 30 days after the last treatment visit and one year after the first treatment visit.

Clinical Study Identifier: NCT02737306

Contact Investigators or Research Sites near you

Start Over

Kush Dhody, MBBS, MS

University of Pennsylvania
Philadelphia, PA United States
  Connect »

Kush Dhody, MBBS, MS

West Virginia University Medicine
Morgantown, WV United States
  Connect »

Kush Dhody, MBBS, MS

University of Miami Sylvester Comprehensive Cancer Center
Miami, FL United States
  Connect »

Kush Dhody, MBBS, MS

Loyola University Medical Center Cardinal Bernardin Cancer Center
Maywood, IL United States
  Connect »

Kush Dhody, MBBS, MS

Barbara Ann Karmanos Cancer Institute
Detroit, MI United States
  Connect »

Kush Dhody, MBBS, MS

University of Minnesota
Minneapolis, MN United States
  Connect »

Kush Dhody, MBBS, MS

Wake Forest Baptist Health
Winston-Salem, NC United States
  Connect »

Kush Dhody, MBBS, MS

Texas Transplant Institute Methodist Hospital
San Antonio, TX United States
  Connect »