Last updated on November 2017

If you have Chronic Obstructive Pulmonary Disease (COPD), you need to know about Alpha-1 Antitrypsin Deficiency.


Brief description of study

If you have Chronic Obstructive Pulmonary Disease (COPD), you need to know about Alpha-1 Antitrypsin Deficiency.

Detailed Study Description

What is Alpha-1 Antitrypsin Deficiency?

Alpha-1 Antitrypsin Deficiency is a genetic (inherited) condition that may result in serious lung disease in adults and/or liver disease at any age.

Alpha-1 Antitrypsin Deficiency occurs when there is a lack of a protein in the blood called alpha-1 antitrypsin, or AAT. AAT is mainly produced by the liver. The main function of AAT is to protect the lungs from inflammation caused by infection and inhaled irritants such as tobacco smoke.

The low level of AAT in the blood occurs because the AAT is abnormal and cannot be released from the liver at the normal rate. This leads to a build-up of abnormal AAT in the liver that can cause liver disease and a decrease of AAT in the blood which can lead to lung disease.

Alpha-1 Antitrypsin Deficiency cannot be diagnosed by symptoms or by a medical examination alone; you need to get a simple, reliable blood test to know for sure.

Alpha-1 Antitrypsin Deficiency can lead to lung destruction and is often first diagnosed as asthma or smoking-related Chronic Obstructive Pulmonary Disease (COPD).

Up to 3% of all people diagnosed with COPD may have undetected Alpha-1 Antitrypsin Deficiency.

A research study of an investigational medication is enrolling volunteers with pulmonary emphysema due to an Alpha-1 Antitrypsin Deficiency. This research study is being conducted in partnership with Wilmington Health.

Clinical Study Identifier: TX81495

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PMG Research of Wilmington

PMG Research of Wilmington
Wilmington, NC USA
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