Last updated on October 2017

A Trial to Compare Nintedanib With Placebo for Patients With Scleroderma Related Lung Fibrosis


Brief description of study

Systemic Sclerosis (SSc) is a devastating disease of unknown etiology. Patients suffer from multiple organ fibrosis whereas lung fibrosis (interstitial lung disease, ILD) is one of the main driver for mortality. There is preclinical evidence for efficacy of nintedanib in SSc and associated ILD (SSc-ILD) and the anti-fibrotic efficacy of nintedanib was proven in idiopathic pulmonary fibrosis patients, who are presenting a similar pattern regarding lung fibrosis. Hence it is the purpose of the trial to confirm the efficacy and safety of nintedanib 150 mg bid in treating patients with SSc-ILD, compared with placebo. The trial will be conducted as a double blind, randomised, placebo-controlled trial with primary efficacy evaluation at week 52 and placebo-controlled treatment until last patient out (up to a maximum of 100 weeks). Respiratory function is globally accepted for assessment of treatment effects in patients with lung fibrosis. The chosen endpoint (Forced Vital Capacity (FVC) decline) is easy to obtain and is part of the usual examinations done in patients with SSc-ILD.

Clinical Study Identifier: NCT02597933

.

Contact Investigators or Research Sites near you

Start Over

Please choose location

View all locations

Boehringer Ingelheim Call Center

University of California
Los Angeles, CA United States
  Connect »

Boehringer Ingelheim Call Center

University of California
Sacramento, CA United States
  Connect »

Boehringer Ingelheim Call Center

University of California
San Francisco, CA United States
  Connect »

Boehringer Ingelheim Call Center

Stanford University Medical Center
Stanford, CA United States
  Connect »

Boehringer Ingelheim Call Center

University of Colorado Denver
Aurora, CO United States
  Connect »

Boehringer Ingelheim Call Center

Yale University School of Medicine
New Haven, CT United States
  Connect »

Boehringer Ingelheim Call Center

Georgetown University
Washington, D.C., United States
  Connect »

Boehringer Ingelheim Call Center

University of Florida College of Medicine
Jacksonville, FL United States
  Connect »

Boehringer Ingelheim Call Center

University of Miami
Miami, FL United States
  Connect »

Boehringer Ingelheim Call Center

The Emory Clinic
Atlanta, GA United States
  Connect »

Boehringer Ingelheim Call Center

Northwestern University
Chicago, IL United States
  Connect »

Boehringer Ingelheim Call Center

University of Chicago
Chicago, IL United States
  Connect »

Boehringer Ingelheim Call Center

University of Iowa
Iowa City, IA United States
  Connect »

Boehringer Ingelheim Call Center

Univeristy of Kansas Medical Center
Kansas City, KS United States
  Connect »

Boehringer Ingelheim Call Center

University of Louisville
Louisville, KY United States
  Connect »

Boehringer Ingelheim Call Center

Tulane University Hospital and Clinic
New Orleans, LA United States
  Connect »

Boehringer Ingelheim Call Center

Johns Hopkins Scleroderma Center
Baltimore, MD United States
  Connect »

Boehringer Ingelheim Call Center

Massachusetts General Hospital
Boston, MA United States
  Connect »

Boehringer Ingelheim Call Center

Boston Medical Center
Boston, MA United States
  Connect »

Boehringer Ingelheim Call Center

University of Michigan Health System
Ann Arbor, MI United States
  Connect »

Boehringer Ingelheim Call Center

Henry Ford Health System
Detroit, MI United States
  Connect »

Boehringer Ingelheim Call Center

University of Minnesota Masonic Cancer Center
Minneapolis, MN United States
  Connect »

Boehringer Ingelheim Call Center

Mayo Clinic-Rochester
Rochester, MN United States
  Connect »

Boehringer Ingelheim Call Center

The Lung Research Center, LLC
Chesterfield, MO United States
  Connect »

Boehringer Ingelheim Call Center

Washington University School of Medicine
Saint Louis, MO United States
  Connect »

Boehringer Ingelheim Call Center

Hospital for Special Surgery
New York, NY United States
  Connect »

Boehringer Ingelheim Call Center

Ichan School of Medicine at Mount Sinai
New York, NY United States
  Connect »

Boehringer Ingelheim Call Center

Columbia University Medical Center-New York Presbyterian Hospital
New York, NY United States
  Connect »

Boehringer Ingelheim Call Center

Duke University Medical Center
Durham, NC United States
  Connect »

Boehringer Ingelheim Call Center

University of Cincinnati Health
Cincinnati, OH United States
  Connect »

Boehringer Ingelheim Call Center

Cole Eye Institute
Cleveland, OH United States
  Connect »

Boehringer Ingelheim Call Center

University of Toledo
Toledo, OH United States
  Connect »

Boehringer Ingelheim Call Center

Penn State Milton S. Hershey Medical Center
Hershey, PA United States
  Connect »

Boehringer Ingelheim Call Center

The Univ of PA Perelman Ctr for Advncd Medicine
Philadelphia, PA United States
  Connect »

Boehringer Ingelheim Call Center

Thomas Jefferson University
Philadelphia, PA United States
  Connect »

Boehringer Ingelheim Call Center

Temple University Hospital
Philadelphia, PA United States
  Connect »

Boehringer Ingelheim Call Center

Medical University of South Carolina
Charleston, SC United States
  Connect »

Boehringer Ingelheim Call Center

University of South Carolina
Columbia, SC United States
  Connect »

Boehringer Ingelheim Call Center

Vanderbilt Pulmonary Clinic
Nashville, TN United States
  Connect »

Boehringer Ingelheim Call Center

University of Texas Southwestern Medical Center
Dallas, TX United States
  Connect »

Boehringer Ingelheim Call Center

The University Of Texas at Houston
Houston, TX United States
  Connect »

Boehringer Ingelheim Call Center

University of Utah Health Sciences Center
Salt Lake City, UT United States
  Connect »

Boehringer Ingelheim Call Center

Inova Fairfax Medical Campus
Falls Church, VA United States
  Connect »

Boehringer Ingelheim Call Center

Virginia Mason Medical Center
Seattle, WA United States
  Connect »

Boehringer Ingelheim Call Center

University of Washington
Seattle, WA United States
  Connect »

Boehringer Ingelheim Call Center

Froedtert Hospital
Milwaukee, WI United States
  Connect »

Boehringer Ingelheim Call Center

Hospital Militar Central
Buenos Aires, Argentina
  Connect »

Boehringer Ingelheim Call Center

Centro de Investigaciones Metab licas (CINME)
C.a.b.a, Argentina
  Connect »

Boehringer Ingelheim Call Center

APRILLUS
Ciudad Autonoma Buenos Aires, Argentina
  Connect »

Boehringer Ingelheim Call Center

CEMER-Centro Medico De Enfermedades Respiratorias
Florida, FL Argentina
  Connect »

Boehringer Ingelheim Call Center

Royal Prince Alfred Hospital, Respiratory Dept
Camperdown, Australia
  Connect »

Boehringer Ingelheim Call Center

Concord Repatriation General Hospital
Concord, Australia
  Connect »

Boehringer Ingelheim Call Center

Liverpool Hospital
Sydney, Australia
  Connect »

Boehringer Ingelheim Call Center

Royal Adelaide Hospital
Adelaide, Australia
  Connect »

Boehringer Ingelheim Call Center

St Vincents Melbourne
Fitzroy, Australia
  Connect »

Boehringer Ingelheim Call Center

Brussels - UNIV Erasme
Bruxelles, Belgium
  Connect »

Boehringer Ingelheim Call Center

Brussels - UNIV St-Luc
Bruxelles, Belgium
  Connect »

Boehringer Ingelheim Call Center

Centre Hospitalier Universitaire de Li ge
Liège, Belgium
  Connect »

Boehringer Ingelheim Call Center

Edumed - Educacao e Saude SA
Curitiba, Brazil
  Connect »

Boehringer Ingelheim Call Center

Saint Joseph's Healthcare
Hamilton, ON Canada
  Connect »

Boehringer Ingelheim Call Center

Mount Sinai Hospital
Toronto, ON Canada
  Connect »

Boehringer Ingelheim Call Center

Jewish General Hospital
Montreal, QC Canada
  Connect »

Boehringer Ingelheim Call Center

Hospital Cl nico Reg. de Concepci n "Dr. G. Grant Benavente"
Concepción, Chile
  Connect »

Boehringer Ingelheim Call Center

Centro de Investigaci n del Maule
Talca, Chile
  Connect »

Boehringer Ingelheim Call Center

Peking Union Medical College Hospital
Beijing, China
  Connect »

Boehringer Ingelheim Call Center

Beijing Chao-Yang Hospital
Beijing, China
  Connect »

Boehringer Ingelheim Call Center

Beijing Hospital
Beijing, China
  Connect »

Boehringer Ingelheim Call Center

First Hospital of Jilin University
Changchun, China
  Connect »

Boehringer Ingelheim Call Center

West China Hospital
Chengdu, China
  Connect »

Boehringer Ingelheim Call Center

The First Affiliated Hospital of Anhui Medical University
Hefei, China
  Connect »

Boehringer Ingelheim Call Center

Huashan Hospital, Fudan University
Shanghai, China
  Connect »

Boehringer Ingelheim Call Center

The First Hospital of Chinese Medical University
Shenyang, China
  Connect »

Boehringer Ingelheim Call Center

Zhuzhou Central Hospital
Zhuzhou, China
  Connect »

Boehringer Ingelheim Call Center

Institute of Rheumathology Prague
Prague, Czechia
  Connect »

Boehringer Ingelheim Call Center

Thomayer Hospital
Praha 4, Czechia
  Connect »

Boehringer Ingelheim Call Center

Odense Universitetshospital
Odense, Denmark
  Connect »

Boehringer Ingelheim Call Center

Aarhus Universitetshospital
Århus, Denmark
  Connect »

Boehringer Ingelheim Call Center

HYKS Keuhkosairauksien
Helsinki, Finland
  Connect »

Boehringer Ingelheim Call Center

TYKS, Keuhkosairauksien klinikka, Turku
Turku, Finland
  Connect »

Boehringer Ingelheim Call Center

HOP de la Cavale Blanche
Brest, France
  Connect »

Boehringer Ingelheim Call Center

HOP Claude Huriez
Lille cedex, France
  Connect »

Boehringer Ingelheim Call Center

HOP Arnaud de Villeneuve
Montpellier, France
  Connect »

Boehringer Ingelheim Call Center

HOP H tel-Dieu
Nantes, France
  Connect »

Boehringer Ingelheim Call Center

HOP Pontchaillou
Rennes, France
  Connect »

Boehringer Ingelheim Call Center

HOP Charles Nicolle
Rouen cedex, France
  Connect »

Boehringer Ingelheim Call Center

Kerckhoff-Klinik, Bad Nauheim
Bad Nauheim, Germany
  Connect »

Boehringer Ingelheim Call Center

Krankenhaus, Donaustauf
Donaustauf, Germany
  Connect »

Boehringer Ingelheim Call Center

Universit tsklinikum Carl Gustav Carus Dresden
Dresden, Germany
  Connect »

Boehringer Ingelheim Call Center

Universit tsklinikum Erlangen
Erlangen, Germany
  Connect »

Boehringer Ingelheim Call Center

Universit tsmedizin Greifswald
Greifswald, Germany
  Connect »

Boehringer Ingelheim Call Center

Asklepios Klinik Altona
Hamburg, Germany
  Connect »

Boehringer Ingelheim Call Center

Medizinische Hochschule Hannover
Hannover, Germany
  Connect »

Boehringer Ingelheim Call Center

Thoraxklinik-Heidelberg gGmbH am Universit tsklinikum Heidelberg
Heidelberg, Germany
  Connect »

Boehringer Ingelheim Call Center

Universit tsklinikum Schleswig-Holstein, Campus Kiel
Kiel, Germany
  Connect »

Boehringer Ingelheim Call Center

Universit tsklinikum K ln (A R)
Köln, Germany
  Connect »

Boehringer Ingelheim Call Center

Klinikum der Universit t M nchen - Campus Gro hadern
München, Germany
  Connect »

Boehringer Ingelheim Call Center

Universit tsklinikum M nster
Münster, Germany
  Connect »

Boehringer Ingelheim Call Center

Universit tsklinikum T bingen
Tübingen, Germany
  Connect »

Boehringer Ingelheim Call Center

General Hospital of Athens "Laiko"
Athens, Greece
  Connect »

Boehringer Ingelheim Call Center

Semmelweis University, Dept. Pulmonology
Budapest, Hungary
  Connect »

Boehringer Ingelheim Call Center

Sanjivani Superspeciality Hospital Pvt. Ltd.
Ahmedabad, India
  Connect »

Boehringer Ingelheim Call Center

St John's Medical College
Bangalore, India
  Connect »

Boehringer Ingelheim Call Center

Ramaiah Medical College and Hospitals
Bangalore, India
  Connect »

Boehringer Ingelheim Call Center

Mazumdar Shaw Medical centre
Bangalore, India
  Connect »

Boehringer Ingelheim Call Center

Postgraduate Institute of Medical Education And Research
Chandigarh, India
  Connect »

Boehringer Ingelheim Call Center

Care Hospital
Hyderabad, India
  Connect »

Boehringer Ingelheim Call Center

Nizam's Institute of Medical Sciences
Hyderabad, India
  Connect »

Boehringer Ingelheim Call Center

Fortis Hospital
Kolkata, India
  Connect »

Boehringer Ingelheim Call Center

P.D. Hinduja National Hospital
Mumbai, India
  Connect »

Boehringer Ingelheim Call Center

Getwell Hospital & Research Institute
Nagpur, India
  Connect »

Boehringer Ingelheim Call Center

All India Institute of Medical Science
New Delhi, India
  Connect »

Boehringer Ingelheim Call Center

Sir Gangaram Hospital
New Delhi, India
  Connect »

Boehringer Ingelheim Call Center

Jehangir Clinical Development Centre Pvt. Ltd.
Pune, India
  Connect »

Boehringer Ingelheim Call Center

B.J. Medical College and Sasoon General Hospital
Pune, India
  Connect »

Boehringer Ingelheim Call Center

Inamdar Multispeciality Hospital
Pune, India
  Connect »

Boehringer Ingelheim Call Center

Christian Medical College
Vellore, India
  Connect »

Boehringer Ingelheim Call Center

Cork University Hospital
Cork, Ireland
  Connect »

Boehringer Ingelheim Call Center

Bnei Zion Medical Center, Haifa
Haifa, Israel
  Connect »

Boehringer Ingelheim Call Center

Rambam Medical Center
Haifa, Israel
  Connect »

Boehringer Ingelheim Call Center

Rabin Medical Center Beilinson
Petah Tiqwa, Israel
  Connect »

Boehringer Ingelheim Call Center

Sourasky Medical Center
Tel Aviv, Israel
  Connect »

Boehringer Ingelheim Call Center

Az. Ospedaliere Umberto I di Ancona
Ancona, Italy
  Connect »

Boehringer Ingelheim Call Center

Universit degli Studi di Genova
Genova, Italy
  Connect »

Boehringer Ingelheim Call Center

A.O. San Gerardo di Monza
Monza, Italy
  Connect »

Boehringer Ingelheim Call Center

A.O Universitaria - Universit degli Studi della Campania Luigi Vanvitelli
Napoli, Italy
  Connect »

Boehringer Ingelheim Call Center

Universit degli Studi Padova
Padova, Italy
  Connect »

Boehringer Ingelheim Call Center

Azienda Universitaria-Universita' La Sapienza
Roma, Italy
  Connect »

Boehringer Ingelheim Call Center

Tosei General Hospital
Aichi, Seto, Japan
  Connect »

Boehringer Ingelheim Call Center

Kurume University Hospital
Fukuoka, Kurume, Japan
  Connect »

Boehringer Ingelheim Call Center

Sapporo Medical University Hospital
Hokkaido, Sapporo, Japan
  Connect »

Boehringer Ingelheim Call Center

Iwate Medical University Hospital
Iwate, Morioka, Japan
  Connect »

Boehringer Ingelheim Call Center

St. Marianna University School of Medicine Hospital
Kanagawa, Kawasaki, Japan
  Connect »

Boehringer Ingelheim Call Center

Kitasato University Hospital
Kanagawa, Sagamihara, Japan
  Connect »

Boehringer Ingelheim Call Center

Kanagawa Cardiovascular and Respiratory Center
Kanagawa, Yokohama, Japan
  Connect »

Boehringer Ingelheim Call Center

Kyoto University Hospital
Kyoto, Kyoto, Japan
  Connect »

Boehringer Ingelheim Call Center

Nagasaki University Hospital
Nagasaki, Nagasaki, Japan
  Connect »

Boehringer Ingelheim Call Center

Kindai University Hospital
Osaka, Osakasayama, Japan
  Connect »

Boehringer Ingelheim Call Center

National Hospital Organization Kinki-Chuo Chest Medical Center
Osaka, Sakai, Japan
  Connect »

Boehringer Ingelheim Call Center

Osaka Medical College Hospital
Osaka, Takatsuki, Japan
  Connect »

Boehringer Ingelheim Call Center

Saitama Medical University Hospital
Saitama, Iruma-gun, Japan
  Connect »

Boehringer Ingelheim Call Center

Hamamatsu University Hospital
Shizuoka, Hamamatsu, Japan
  Connect »

Boehringer Ingelheim Call Center

Tokushima University Hospital
Tokushima, Tokushima, Japan
  Connect »

Boehringer Ingelheim Call Center

Juntendo University Hospital
Tokyo, Bunkyo-Ku, Japan
  Connect »

Boehringer Ingelheim Call Center

Nippon Medical School Hospital
Tokyo, Bunkyo-Ku, Japan
  Connect »

Boehringer Ingelheim Call Center

Toho University Omori Medical Center
Tokyo, Ota-ku, Japan
  Connect »

Boehringer Ingelheim Call Center

Institute of Rheumatology Tokyo Women's Medical University
Tokyo, Shinjyuku-ku, Japan
  Connect »

Boehringer Ingelheim Call Center

Instituto Nacional de Enfermedades Respiratorias Ismael Cos o Villegas
Ciudad de México, Mexico
  Connect »

Boehringer Ingelheim Call Center

VU Medisch Centrum
Amsterdam, Netherlands
  Connect »

Boehringer Ingelheim Call Center

Leids Universitair Medisch Centrum (LUMC)
Leiden, Netherlands
  Connect »

Boehringer Ingelheim Call Center

Radboud Universitair Medisch Centrum
Nijmegen, Netherlands
  Connect »

Boehringer Ingelheim Call Center

Erasmus Medisch Centrum
Rotterdam, Netherlands
  Connect »

Boehringer Ingelheim Call Center

Oslo Universitetssykehus HF, Rikshospitalet
Oslo, Norway
  Connect »

Boehringer Ingelheim Call Center

Universitetssykehuset Nord-Norge, Troms
Tromsø, Norway
  Connect »

Boehringer Ingelheim Call Center

Dr.Biziel UnivHosp#2,Rheumat&Connec.Tissue Disease,Bydgoszcz
Bydgoszcz, Poland
  Connect »

Boehringer Ingelheim Call Center

Specialist Center ALL-MED, Krakow
Krakow, Poland
  Connect »

Boehringer Ingelheim Call Center

Dobry Lekarz,Spec.Med.Clinics,Private Prac,Krakow
Krakow, Poland
  Connect »

Boehringer Ingelheim Call Center

Reumed, Private Practice, Lublin
Lublin, Poland
  Connect »

Boehringer Ingelheim Call Center

Indep.Pblic Clin.Hosp#Lublin,Dermat,Venereol.&Pediatric Dept
Lublin, Poland
  Connect »

Boehringer Ingelheim Call Center

EMED, Center of Medical Services,Private Prac,Rzeszow
Rzeszow, Poland
  Connect »

Boehringer Ingelheim Call Center

Indep.Pblic Clin.Hosp#1,Dermatol,Venereol&Allerg.dep,Wroclaw
Wroclaw, Poland
  Connect »

Boehringer Ingelheim Call Center

Hospital Garcia de Orta, EPE
Almada, Portugal
  Connect »

Boehringer Ingelheim Call Center

Hospital Fernando Fonseca, EPE
Amadora, Portugal
  Connect »

Boehringer Ingelheim Call Center

CHUC - Centro Hospitalar e Universit rio de Coimbra, EPE
Coimbra, Portugal
  Connect »

Boehringer Ingelheim Call Center

ULSAM, EPE - Hospital Conde de Bertiandos
Ponte de Lima, Portugal
  Connect »

Boehringer Ingelheim Call Center

Centro Hospitalar S o Jo o,EPE
Porto, Portugal
  Connect »

Boehringer Ingelheim Call Center

Centro Hospitalar de Vila Nova de Gaia
Vila Nova de Gaia, Portugal
  Connect »

Boehringer Ingelheim Call Center

Hospital Vall d'Hebron
Barcelona, Spain
  Connect »

Boehringer Ingelheim Call Center

Hospital Santa Creu i Sant Pau
Barcelona, Spain
  Connect »

Boehringer Ingelheim Call Center

Hospital General Universitario Gregorio Mara n
Madrid, Spain
  Connect »

Boehringer Ingelheim Call Center

Hospital Universitario 12 de Octubre
Madrid, Spain
  Connect »

Boehringer Ingelheim Call Center

Hospital Universitario Marqu s de Valdecilla
Santander, Spain
  Connect »

Boehringer Ingelheim Call Center

Hospital Dr. Peset
Valencia, Spain
  Connect »

Boehringer Ingelheim Call Center

Hospital Polit cnic La Fe
Valencia, Spain
  Connect »

Boehringer Ingelheim Call Center

Hospital lvaro Cunqueiro
Vigo, Spain
  Connect »

Boehringer Ingelheim Call Center

Clinical Rheumatology Research Center Sahlgrenska
Gothenburg, Sweden
  Connect »

Boehringer Ingelheim Call Center

Kantonspital St. Gallen, Rheumatologie Department
St. Gallen, Switzerland
  Connect »

Boehringer Ingelheim Call Center

Universit tsspital Z rich
Zürich, Switzerland
  Connect »

Boehringer Ingelheim Call Center

Glasgow Royal Infirmary
Glasgow, United Kingdom
  Connect »

Boehringer Ingelheim Call Center

Royal Free Hospital
London, United Kingdom
  Connect »

Boehringer Ingelheim Call Center

Guy's Hospital
London, United Kingdom
  Connect »

Boehringer Ingelheim Call Center

Salford Royal Hospital
Salford, United Kingdom
  Connect »