Last updated on August 2018

Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C) ROS1 or ALK Gene Rearrangements (Fusions)


Brief description of study

This is an open-label, multicenter, global Phase 2 basket study of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor an NTRK1/2/3, ROS1, or ALK gene fusion. Patients will be assigned to different baskets according to tumor type and gene fusion.

Clinical Study Identifier: NCT02568267

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Reference Study ID Number: GO40782 ...

University of Colorado Cancer Center
Aurora, CO United States
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Yale University
New Haven, CT United States
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University of Hawaii Cancer Center
Honolulu, HI United States
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University of Michigan Comprehensive Cancer Center
Ann Arbor, MI United States
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Karmanos Cancer Center
Detroit, MI United States
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Memorial Sloan Kettering Cancer Center
New York, NY United States
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Levine Cancer Institute
Charlotte, NC United States
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Cleveland Clinic
Cleveland, OH United States
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Providence Portland Medical Center
Portland, OR United States
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Baylor Scott & White Health
Temple, TX United States
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Virginia Cancer Specialists, PC
Fairfax, VA United States
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Wheaton Franciscan Cancer Care-All Saints
Franklin, WI United States
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Flinders Medical Centre
Bedford Park, Australia
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Austin Hospital
Heidelberg, Australia
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Liverpool Hospital
Liverpool, Australia
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Newcastle Private Hospital
New Lambton Heights, Australia
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Hong Kong Integrated Oncology Centre
Hong Kong, Hong Kong
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Queen Elizabeth Hospital
Kowloon, Hong Kong
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The Chinese University of Hong Kong
Shatin, Hong Kong
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Fondazione IRCCS Istituto Nazionale dei Tumori
Milano, Italy
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Western Regional Medical Center at Cancer Treatment Centers of America
Goodyear, AZ United States
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The University of Arizona Cancer Center at Dignity Health; St. Josephs Hospital and Medical Center
Phoenix, AZ United States
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Mayo Clinic
Scottsdale, AZ United States
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City of Hope Cancer Center; Division of Medical Oncology & Experimental Therapeutics
Duarte, CA United States
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Scripps Clinic
La Jolla, CA United States
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University of California San Diego Moores Cancer Center; Dept of Lung Cancer
La Jolla, CA United States
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University of Southern California Medical Center
Los Angeles, CA United States
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Univ Of California Irvine College Of Medicine; 300194620
Orange, CA United States
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UCSF Mount Zion Medical Ctr
San Francisco, CA United States
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Sarcoma Oncology Center
Santa Monica, CA United States
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Georgetown University Medical Center Lombardi Cancer Center
Washington, WA United States
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Florida Cancer Specialists - Sarasota
Sarasota, FL United States
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H. Lee Moffitt Cancer Center and Research Inst.
Tampa, FL United States
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Cleveland Clinic Florida
Weston, FL United States
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University Cancer & Blood Center, LLC; Research
Athens, GA United States
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Winship Cancer Institute of Emory University
Atlanta, GA United States
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Southeastern Regional Medical Center, Inc.
Newnan, GA United States
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Northwestern University
Chicago, IL United States
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Advocate Medical Group - Park Ridge, Luther Lane - Oncology
Park Ridge, IL United States
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Midwestern Regional Medical Center
Zion, IL United States
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Weinberg Cancer Institution at Franklin Square
Baltimore, MD United States
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Massachusetts General Hospital
Boston, MA United States
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Dana-Farber Cancer Institute; Center for Sarcoma and Bone Oncology, D1212
Boston, MA United States
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Beth Israel Deaconess Medical Center
Boston, MA United States
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Henry Ford Hospital
Detroit, MI United States
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Regents of the University of Minnesota
Minneapolis, MN United States
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Washington University; Wash Uni. Sch. Of Med
Saint Louis, MO United States
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Comprehensive Cancer Centers of Nevada (CCCN) - Central Valley
Las Vegas, NV United States
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Dartmouth Hitchcock Medical Center
Lebanon, NH United States
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North Shore Hem Onc Associates
East Setauket, NY United States
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Duke Cancer Institute
Durham, NC United States
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OSU, James Cancer Hospital
Columbus, OH United States
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Cancer Treatment Centers of America; Tulsa
Tulsa, OK United States
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Oregan Health & Science Univ
Portland, OR United States
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Cancer Treatment Centers of America - Eastern Regional Medical Center
Philadelphia, PA United States
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Mary Crowley Medical Research Center
Dallas, TX United States
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University Hospital Medical Oncology Clinic; Harold C. Simmons Comprehensive Cancer Center
Dallas, TX United States
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University of Texas MD Anderson Cancer Center; Unit 432 Thoracic Head and Neck Medical Oncology
Houston, TX United States
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University of Utah Hospitals & Clinics
Salt Lake City, UT United States
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Virginia Oncology Associates - Hampton
Hampton, VA United States
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University of Washington Seattle Cancer Care Alliance
Seattle, WA United States
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Border Medical Oncology Research Unit
Albury, Australia
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Institut Bergonie; Oncologie
Bordeaux, France
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Centre Oscar Lambret; Chir Cancerologie General
Lille, France
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Centre Leon Berard; Departement Oncologie Medicale
Lyon, France
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H pital de la Timone; Oncologie M dicale H matologie & Soins Palliatifs
Marseille cedex 5, France
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H pital Nord - AP-HM Marseille# ; Service d'Oncologie Multidisciplinaire
Marseille, France
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Institut de Recherche en Canc rologie de Montpellier
Montpellier cedex 5, France
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H pital Europ en Georges Pompidou ; H matologie Oncologie
Paris cedex 15, France
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Institut Curie; Oncologie Medicale
Paris, France
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Institut Claudius Regaud; Departement Oncologie Medicale
Toulouse, France
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Institut Gustave Roussy; Pathologie Thoracique
Villejuif cedex, France
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Evang. Lungenklinik Berlin Klinik f r Pneumologie
Berlin, Germany
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Universit tsklinik der Carl Gustav Carus der Technischen Universit t Dresden; Klinik und Poliklinik
Dresden, Germany
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Princess Margaret Hospital
Hong Kong, Hong Kong
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The University of Hong Kong
Hong Kong, Hong Kong
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Seconda Universit degli Studi di Napoli; Servizio Epato-Gastroenterologia
Napoli, Italy
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Universit Campus Bio-Medico di Roma ; Oncologia Medica
Roma, Italy
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Azienda Ospedaliero Universitaria San Martino ; Lung Cancer Unit
Genova, Italy
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Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda); Oncologico -Onc.Falck
Milano, Italy
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Fondazione del Piemonte per l'Oncologia - IRCCS;Ematologia
Candiolo, Italy
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Azienda Ospedaliero-Universitaria S.Luigi Gonzaga ; SSD Oncologia Polmonare
Orbassano, Italy
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A.O Citt della Salute e della Scienza di Torino ; Colorectal Cancer Unit (CRCU) - SSCVD
Torino, Italy
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Azienda Ospedaliero - Universitaria Pisana U.O. Oncologia Medica 2 Universitaria - Polo Oncologico
Pisa, Italy
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Azienda Ospedaliera di Perugia Ospedale S. Maria della Misericordia ; S.C. Oncologia Medica
Perugia, Italy
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IOV - Istituto Oncologico Veneto - IRCCS; Oncologia Medica II
Padova, Italy
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Aichi Cancer Center Hospital; Respiratory Medicine
Aichi, Japan
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NHO Shikoku Cancer Center; Dept of Respiratory Medicine
Ehime, Japan
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National Hospital Organization Kyushu Medical Center; Respiratory Internal Medicine
Fukuoka, Japan
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Hyogo Cancer Center, Dept of Respiratory Medicine
Hyogo, Japan
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National Cancer Center Hospital; Dept of Respiratory Medicine
Kashiwa-shi, Japan
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Miyagi Cancer Center; Respiratory Medicine
Miyagi, Japan
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Niigata Cancer Center Hospital; Internal Medicine
Niigata, Japan
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OSAKA CITY GENERAL HOSPITAL;Medical Oncology
Osaka, Japan
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Kindai University Hospital; Medical Oncology
Osaka, Japan
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Shizuoka Cancer Center; Respiratory Internal Medicine
Shizuoka, Japan
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Chungbuk National University Hospital
Cheongju-si, Korea, Republic of
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Seoul National University Hospital
Seoul, Korea, Republic of
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Severance Hospital, Yonsei University Health System
Seoul, Korea, Republic of
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Asan Medical Center.
Seoul, Korea, Republic of
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Samsung Medical Center
Seoul, Korea, Republic of
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NKI The Netherlands Cancer Institute
Amsterdam, Netherlands
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Leids Universitair Medisch Centrum
Leiden, Netherlands
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Uniwersyteckie Centrum Kliniczne; Klinika Onkologii i Radioterapii
Gdansk, Poland
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Centrum Onkologii-Instytut im.M.Sklodowskiej Curie; Dept of Nuclear Med. and Endocrine Oncology
Gliwice, Poland
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Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy; Dept of Pulmonology & subdiv. of oncology
Otwock, Poland
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Universit tsmedizin G ttingen ; Abteilung H matologie und Onkologie
Göttingen, Germany
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Universitaetsklinikum Koeln; Innere Medizin I, Haematologie
Köln, Germany
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