Last updated on October 2017

Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C) ROS1 or ALK Gene Rearrangements (Fusions)


Brief description of study

This is an open-label, multicenter, global Phase 2 basket study of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor an NTRK1/2/3, ROS1, or ALK gene fusion. Patients will be assigned to different baskets according to tumor type and gene fusion.

Clinical Study Identifier: NCT02568267

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Hemant Patel, MD

Northwest Alabama Cancer Center
Muscle Shoals, AL United States
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Ashish Sangal, MD

Cancer Treatment Centers of America
Goodyear, AZ United States
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Helen Ross, MD

Mayo Clinic Hospital
Scottsdale, AZ United States
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Ignyta Inc.

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Little Rock, AR United States
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Marwan Fakih, MD

City of Hope Cancer Center
Duarte, CA United States
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Darren Sigal, MD

Scripps Clinic Medical Group
La Jolla, CA United States
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Lyudmila Bazhenova, MD

University of California San Diego Moores Cancer Center
La Jolla, CA United States
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Barbara Gitlitz, MD

University of Southern California - Keck School of Medicine
Los Angeles, CA United States
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Tara Seery, MD

University of California, Irvine College of Medicine
Orange, CA United States
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Jonathan Polikoff, MD

Southern California Kaiser Permanente - All So. California Locations
Panorama City, CA United States
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Collin Blakely, MD

UCSF Mount Zion Medical Center
San Francisco, CA United States
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Sant Chawla, MD

Sarcoma Oncology Research Center LLC
Santa Monica, CA United States
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Ian Anderson, MD

St. Joseph Heritage Healthcare
Santa Rosa, CA United States
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Robert Doebele, MD

University of Colorado Cancer Center
Aurora, CO United States
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Hartford, CT United States
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Hari Deshpande, MD

Yale University
New Haven, CT United States
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Dover, DE United States
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Stephen Liu, MD

Georgetown University - Lombardi Comprehensive Cancer Center
Washington, D.C., United States
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Stephen Liu, MD

Weinberg Cancer Institute at Franklin Square
Washington, D.C., United States
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Manish Patel, MD

Florida Cancer Specialists
Sarasota, FL United States
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Christine Chung, MD

H. Lee Moffitt Cancer Center and Research Institute, Inc.
Tampa, FL United States
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Arun Nagarajan, MD

Cleveland Clinic Florida - Maroone Cancer Center
Weston, FL United States
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Petros Nikolinakos, MD

University Cancer & Blood Center, LLC
Athens, GA United States
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Conor Steuer, MD

Winship Cancer Institute
Atlanta, GA United States
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Ioana Bonta, MD

Cancer Treatment Centers of America
Newnan, GA United States
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Jared Acoba, MD

University of Hawaii Cancer Center
Honolulu, HI United States
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Boise, ID United States
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Chae Young Kwang, MD, MPH, ...

Northwestern University Memorial Hospital
Chicago, IL United States
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Arthur Hooberman, MD

Oncology Specialists, S.C.
Park Ridge, IL United States
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Eugene Ahn, MD

Cancer Treatment Centers of America
Zion, IL United States
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Naveed Chowhan, MD

Baptist Health Cancer Center
New Albany, IN United States
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Des Moines, IA United States
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Topeka, KS United States
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Frankfort, KY United States
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Christopher M. McCanless, MD

Hematology/Oncology Clinic, LLP
Baton Rouge, LA United States
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Augusta, ME United States
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Annapolis, MD United States
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Anna Farago, MD

Massachusetts General Hospital / Beth Israel Deaconess Med Ctr / Dana-Farber Cancer Institute
Boston, MA United States
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John Krauss, MD

University of Michigan Comprehensive Cancer Center
Ann Arbor, MI United States
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Shirish Gadgeel, MD

Karmanos Cancer Center
Detroit, MI United States
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Ding Wang, MD

Henry Ford Health System
Detroit, MI United States
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Dylan Zylla, MD

Health Partners Institute - Park Nicollet Institute
Minneapolis, MN United States
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Manish Patel, MD

University of Minnesota
Minneapolis, MN United States
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Jackson, MS United States
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Saiama Waqar, MD

Washington University School of Medicine
Saint Louis, MO United States
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Helena, MT United States
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Lincoln, NE United States
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Fadi Braiteh, MD

Comprehensive Cancer Centers of Nevada
Las Vegas, NV United States
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Mary Chamberlin, MD

Dartmouth-Hitchcock Medical Center
Lebanon, NH United States
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Trenton, NJ United States
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Santa Fe, NM United States
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David Chu, MD

North Shore Hematology Oncology Associates, PC
East Setauket, NY United States
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Jonathan Goldberg, MD

Northern Westchester Hospital Association
Mount Kisco, NY United States
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Alexander Drilon, MD

Memorial Sloan Kettering Cancer Center
New York, NY United States
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Edward Kim, MD

Levine Cancer Institute
Charlotte, NC United States
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Richard Riedel, MD

Duke University Medical Center/ Duke Cancer Center
Durham, NC United States
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Bismarck, ND United States
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Dale Shepard, MD

Cleveland Clinic
Cleveland, OH United States
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Gregory Otterson, MD

OSU - James Comprehensive Cancer Center
Columbus, OH United States
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Theodore Pollock, MD

Cancer Treatment Centers of America
Tulsa, OK United States
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Dr. Rom Leidner

Providence Portland Medical Center
Portland, OR United States
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Matthew Taylor, MD

Oregon Health & Science University
Portland, OR United States
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Pamela Crilley, MD

Cancer Treatment Centers of America
Philadelphia, PA United States
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Providence, RI United States
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Columbia, SC United States
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Pierre, SD United States
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Nashville, TN United States
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John Nemunaitis, MD

Mary Crowley Cancer Research Center
Dallas, TX United States
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Arthur Frankel, MD

University of Texas Southwestern Hospital - Medical Oncology Clinic
Dallas, TX United States
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Jade Homsi, MD

UT Southwestern Medical Center
Dallas, TX United States
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Anthony Conley, MD

MD Anderson Cancer Center
Houston, TX United States
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Sherronda Henderson, MD

Baylor Scott & White Health
Temple, TX United States
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Ignacio Garrido-Laguna, MD

Huntsman Cancer Institute
Salt Lake City, UT United States
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Montpelier, VT United States
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Alexander Spira, MD

Virginia Cancer Specialists, PC
Fairfax, VA United States
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Paul Conkling, MD

Virginia Oncology Associates
Norfolk, VA United States
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Elena Chiorean, MD

University of Washington - Seattle Cancer Care Alliance
Seattle, WA United States
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Charleston, WV United States
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Jonathan Treisman, MD

Wheaton Franciscan Cancer Care-All Saints
Franklin, WI United States
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Cheyenne, WY United States
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Dr. Chris Karapetis

Flinders Medical Centre
Bedford Park, Australia
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Dr. Thomas John

Austin Hospital
Heidelberg, Australia
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Dr. Weng Ng

Liverpool Hospital
Liverpool, Australia
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Dr. Maria Aslam

Newcastle Private Hospital
New Lambton Heights, Australia
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Dr. Craig Underhill

Border Medical Oncology
Wodonga, Australia
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Dr. Christian Rolfo

Antwerp University Hospital
Edegem, Belgium
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Dr. Sophie Cousin

Institut Bergoni
Bordeaux cedex, France
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Dr. Patrick Soulie

Institut de Cancerologie de l'Ouest - Centre Rene Gauducheau
Saint-Herblain, France
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Dr. Nuria Kotecki

Centre Oscar Lambret
Lille Cedex, France
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Dr. Christophe Le Tourneau

Institut Curie - Centre de Lutte Contre le Cancer (CLCC) de Paris
Paris Cedex 05, France
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Dr. Philippe Cassier

Centre L on B rard
Lyon, France
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Dr. Diego Tosi

Institut de Recherche en Canc rologie de Montpellier
Montpellier, France
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Dr. Benjamin Besse

Institut Gustave Roussy
Villejuif cedex, France
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Dr. Patrick Soulie

Institut de Cancerologie de l'Ouest - Centre Paul Papin
Angers, France
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Pr. Florence Duffaud

H pital De La Timone - AP-HM Marseille
Marseille, France
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Dr. Fabrice Barlesi

H pital Nord - AP-HM Marseille
Marseille, France
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Dr. Jacques Medioni

H pital Europ en Georges Pompidou
Paris, France
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Dr. Christian Grohe

Evangelische Lungenklinik Berlin
Berlin, Germany
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Dr. Gunnar Folprecht

Medizinische Fakult t Carl Gustav Carus Medizinische Klinik und Poliklinik I
Dresden, Germany
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Dr. Joachim Von Pawel

Asklepios Fachkliniken Muenchen-Gauting
Gauting, Germany
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Dr. Tobias Raphael Overbeck

Universitaetsmedizin Goettingen
Goettingen, Germany
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Dr. Juergen Wolf

Universitaetsklinikum Koeln
Koeln, Germany
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Dr. Foon Yiu Cheung

Hong Kong Integrated Oncology Centre
Hong Kong, Hong Kong
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Dr. Yu Chung Li

Queen Elizabeth Hospital
Kowloon, Hong Kong
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Dr. Thomas Chung Cheung Yau

Queen Mary Hospital
Kowloon, Hong Kong
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Dr. Ashley Chi Kin Cheng

Princess Margaret Hospital
Lai Chi Kok, Hong Kong
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Dr. Herbert Ho Fung Loong

The Chinese University of Hong Kong
Shatin, Hong Kong
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Dr. Giorgio Scagliotti

SCDU Oncologia Medica - Azienda Ospedaliero-Universitaria San Luigi Gonzaga
Orbassano, Italy
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Dr. Francesco Leone

Fondazione del Piemonte per l'Oncologia IRCC Candiolo
Candiolo, Italy
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Dr. Francesco Grossi

IRCCS AOU San Martino IST
Genova, Italy
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Dr. Filippo De Braud

Fondazione IRCCS Istituto Nazionale dei Tumori
Milano, Italy
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Dr. Salvatore Siena

Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda)
Milano, Italy
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Dr. Fortunato Ciardello

Azienda Ospedaliera Universitaria Seconda Universit di Napoli
Napoli, Italy
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Dr. Vittorina Zagonel

Oncologia Medica 1, Istituto Oncologico Veneto
Padova, Italy
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Dr. Rita Chiari

Azienda Ospedaliera di Perugia Ospedale S. Maria della Misericordia
Perugia, Italy
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Dr. Alfredo Falcone

U.O. Oncologia Medica 2 Universitaria - Azienda Ospedaliero Universitaria Pisana
Pisa, Italy
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Dr. Giuseppe Tonini

Policlinico Universitario Campus Bio-Medico
Roma, Italy
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Dr. Patrizia Racca

Citt della Salute e della Scienza di Torino. Presidio Molinette
Torino, Italy
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