Last updated on February 2018

Study of a Novel BET Inhibitor FT-1101 in Patients With Relapsed or Refractory Hematologic Malignancies

Brief description of study

This is an open-label, multicenter, dose-escalation Phase 1 study in patients with acute leukemia/high-risk MDS or non-Hodgkin Lymphoma, intended to investigate safety, pharmacokinetics, and the pharmacodynamic effects of FT-1101 administered via one or more intermittent dosing schedules. Once the MTD has been established, up to 56 additional patients may be enrolled in 4 expansion cohorts in selected patient populations at the recommended dose for future studies to confirm safety.

Clinical Study Identifier: NCT02543879

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Jeffrey Davis, MBA

Cedars Sinai
Los Angeles, CA United States
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Manish Patel, MD

Florida Cancer Specialists
Sarasota, FL United States
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Lisa Nardelli

Moffitt Cancer Center
Tampa, FL United States
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Deborah Lewis, RN, BSN, CCRP

Levine Cancer Institute
Charlotte, NC United States
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Renee Thompson

Sarah Cannon Research Institute
Nashville, TN United States
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Ricardo Delumpa

MD Anderson Cancer Center
Houston, TX United States
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