Last updated on August 2018

Deep Brain Stimulation (DBS) of the Globus Pallidus (GP) in Huntington's Disease (HD)


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Huntington's Chorea
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Clinically symptomatic and genetically confirmed HD (number of CAG repeats 36)
  • Age 18 years
  • Moderate stage of the disease (UHDRS motor score 30)
  • Chorea despite best medical treatment (UHDRS chorea subscore 10)
  • Mattis Dementia Rating Scale 120 (or > 80% of items testable independently from motor impairment)
  • Patient has stable medication prior six weeks before inclusion
  • Signed informed consent

Exclusion Criteria:

  • Juvenile HD (Westphal variant) or predominant bradykinesia
  • Postural instability with UHDRS retropulsion score > 2
  • Severe comorbidity compromising operability and/or life expectancy and/or quality of life during the trial duration (e.g. cancer with life expectancy < 6 months, NYHA 3 and 4 rising the anaesthetic risk according to the anaesthesiologist)
  • Acute suicidality
  • Acute psychosis (symptoms within previous 6 months)
  • Participation in any interventional clinical trial within 2 months before screening
  • Cortical atrophy grade 3
  • Patients with risk of coagulopathies and/or increased risk of haemorrhage
  • Patients with an implanted pacemaker or defibrillator
  • Pregnancy
  • lactation

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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