Last updated on July 2018

aMAZE Study: LAA Ligation Adjunctive to PVI for Persistent or Longstanding Persistent Atrial Fibrillation


Brief description of study

This study is a prospective, multicenter, randomized (2:1) controlled study to evaluate the safety and effectiveness of the LARIAT System to percutaneously isolate and ligate the Left Atrial Appendage from the left atrium as an adjunct to planned pulmonary vein isolation (PVI) catheter ablation in the treatment of subjects with symptomatic persistent or longstanding persistent atrial fibrillation.

This study will be conducted in two stages:

  • Limited Early Stage (Stage 1): up to 250 subjects at up to 65 sites. (COMPLETED, transitioned to Stage 2)
  • Pivotal Stage/ Phase III (Stage 2): up to 600 subjects at up to 65 sites. (ENROLLING) All subjects from both stages will be included in the primary analysis.

Clinical Study Identifier: NCT02513797

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Vijendra Swarup, M.D.

Arizona Arrhythmia Research Center
Phoenix, AZ United States
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Marwan Bahu, MD

Phoenix Cardiovascular Research Group
Phoenix, AZ United States
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Douglas Gibson, MD

Scripps Clinic
La Jolla, CA United States
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Jonathan Hsu, M.D.

University of California San Diego
La Jolla, CA United States
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Rahul Doshi, M.D.

University of Southern California
Los Angeles, CA United States
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Edward Gerstenfeld, M.D.

University of California San Francisco
San Francisco, CA United States
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Brett Gidney, MD, FACC

Santa Barbara Cottage Hospital
Santa Barbara, CA United States
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James Freeman, M.D. MPH MS

Yale University School of Medicine
New Haven, CT United States
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Saumil Oza, M.D.

St. Vincent's HealthCare
Jacksonville, FL United States
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Michael Hoskins, M.D.

Emory University Hospital
Atlanta, GA United States
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Albert C. Lin, M.D.

Northwestern University / Bluhm Cardiovascular Institute
Chicago, IL United States
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David Wilber, M.D.

Loyola University Center for Heart and Vascular Medicine
Maywood, IL United States
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William Spear, M.D.

Advocate Christ Medical Center
Oak Lawn, IL United States
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Todd Tomson, MD

Northwestern Medicine Central DuPage Hospital
Winfield, IL United States
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Troy Hounshell, D.O.

Iowa Heart Center
West Des Moines, IA United States
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Madhu Reddy, M.D.

University of Kansas Medical Center Research Institute
Kansas City, KS United States
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Freddy M Abi-Samra, M.D.

Ochsner Medical Center
New Orleans, LA United States
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Ronald Berger, M.D.

Johns Hopkins
Baltimore, MD United States
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Moussa Mansour, M.D.

Massachusetts General Hospital
Boston, MA United States
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Rudolph Evonich, III, M.D.

UP Health System- Marquette
Marquette, MI United States
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Pamela P Simons, BS, RT

Morristown Medical Center
Morristown, NJ United States
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Daniel Musat, MD

The Valley Hospital
Ridgewood, NJ United States
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Pamela P Simons, BS, RT

New Mexico Heart Institute
Albuquerque, NM United States
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James O'Brien, M.D.

Albany Medical Center
Albany, NY United States
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Pamela P Simons, BS, RT

Southside Hospital / Feinstein Institute for Medical Research
Bay Shore, NY United States
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Anthony Aizer, M.D.

New York University Langone Medical Center
New York, NY United States
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Pamela P Simons, BS, RT

Mount Sinai Hospital / Icahn School of Medicine
New York, NY United States
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Joseph Levine, M.D.

St. Francis Hospital
Roslyn, NY United States
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John Hummel, M.D.

Ohio State University Wexner Medical Center
Columbus, OH United States
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Sreedhar Billakanty, M.D.

The Ohio Health Research Institute
Columbus, OH United States
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Eric Pena, M.D.

Southern Oregon Cardiology
Medford, OR United States
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Charles Henrikson, M.D.

Oregon Health & Science University
Portland, OR United States
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Sheetal Chandhok, MD

Bryn Mawr Medical Specialists Association / Bryn Mawr Hospital
Bryn Mawr, PA United States
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Pamela P Simons, BS, RT

Butler Medical Providers
Butler, PA United States
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Raveen Bazaz, M.D.

University of Pittsburgh Medical Center
Pittsburgh, PA United States
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Pamela P Simons, BS, RT

Medical University of South Carolina
Charleston, SC United States
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Christopher Ellis, M.D.

Vanderbilt University
Nashville, TN United States
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Rodney Horton, M.D.

Texas Cardiac Arrhythmia Research Foundation
Austin, TX United States
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David Tschopp, M.D.

Austin Heart
Austin, TX United States
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Abdi Rasekh, MD, F.A.C.C.

Baylor - St. Luke's Medical Center
Houston, TX United States
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Brian Deville, M.D.

Baylor Plano Scott & White Research Institute Heart Hospital
Plano, TX United States
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Manoj Panday, M.D.

University of Texas Health Science Center at San Antonio
San Antonio, TX United States
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Stanislav Weiner, M.D.

Christus Trinity Mother Frances Health System
Tyler, TX United States
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Erik Sirulnick, M.D.

DaVita Medical Group
Las Vegas, NV United States
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Luigi DiBiase, M.D.

Montefiore Medical Center
Bronx, NY United States
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Kent Nilsson, MD

Piedmont Athens Regional Cardiology
Athens, GA United States
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Peter Fail, M.D.

Cardiovascular Institute of the South Clinical Research Corperation
Houma, LA United States
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Alan Wimmer, M.D.

St. Luke's Hospital
Kansas City, MO United States
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John C Gurley, M.D.

University of Kentucky
Lexington, KY United States
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