Last updated on August 2018

221AD302 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer's Disease


Brief description of study

The primary objective of the study is to evaluate the efficacy of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the Clinical Dementia Rating-Sum of Boxes (CDR-SB) score as compared with placebo in participants with early AD. Secondary objectives are to assess the effect of monthly doses of aducanumab as compared with placebo on clinical progression as measured by Mini-Mental State Examination (MMSE), AD Assessment Scale-Cognitive Subscale (13 items) [ADAS-Cog 13], and AD Cooperative Study-Activities of Daily Living Inventory (Mild Cognitive Impairment version) [ADCS-ADL-MCI].

Clinical Study Identifier: NCT02484547

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David Geldmacher

University of Alabama at Birmingham
Birmingham, AL United States

David Weidman

Banner Alzheimer's Institute
Phoenix, AZ United States

Stephen Flitman

Xenoscience Inc.
Phoenix, AZ United States

Edward Zamrini

Banner Sun Health Research Institute
Sun City, AZ United States

Aimee Pierce

Institute for Memory Impairments
Irvine, CA United States

Laja Ibraheem

Renewal Behavioral Health
Long Beach, CA United States

Lon Schneider

USC Keck School of Medicine
Los Angeles, CA United States

William Shankle

Hoag Memorial Hospital Presbyterian
Newport Beach, CA United States

Sheryy Soefje

Excell Research, Inc.
Oceanside, CA United States

James Sutton

Pacific Neuroscience Medical Group
Oxnard, CA United States

Donald Anderson

Anderson Clinical Research
Redlands, CA United States

Stephen Thein

Pacific Research Network
San Diego, CA United States

James Lohr

University of California San Diego Medical Center
San Diego, CA United States

Alireza Atri

California Pacific Medical Center
San Francisco, CA United States

John Duffy

Syrentis Clinical Research
Santa Ana, CA United States

Marc Bernstein

St Joseph Heritage Healthcare
Santa Rosa, CA United States

Sharon Sha

Stanford University Medical Center
Stanford, CA United States

Jonathan Woodcock

University Of Colorado Denver
Aurora, CO United States

Ronald Murray

IMMUNOe International Research Centers
Thornton, CO United States

Dario Zagar

Associated Neurologists of Southern Connecticut, PC
Fairfield, CT United States

Christopher Van Dyck

Yale University School Of Medicine
New Haven, CT United States

Bart Sloan

Research Center for Clinical Studies, Inc.
Norwalk, CT United States

Mark Goldstein

JEM Research Institute
Atlantis, FL United States

James Galvin

Florida Atlantic University
Boca Raton, FL United States

William McElveen

Bradenton Research Center, Inc.
Bradenton, FL United States

Kelli Max

Meridien Research
Brooksville, FL United States

Jose De La Gandara

Quantum Laboratories Inc.
Deerfield Beach, FL United States

Harvey Schwartz

Infinity Clinical Research, LLC
Hollywood, FL United States

Neill Graff-Radford

Mayo Clinic in Florida
Jacksonville, FL United States

Jay Rubin

Renstar Medical Research
Ocala, FL United States

Linda Harper

Clinical Neuroscience Solutions, Inc.
Orlando, FL United States

Susan Steen

Axiom Clinical Research of Florida
Tampa, FL United States

Allan Levey

Emory University Cognitive Neurology Clinic & ADRC
Atlanta, GA United States

Jonathan Liss

Medical Research Health and Education Foundation, Inc
Columbus, GA United States

Marshall Nash

NeuroStudies.net, LLC
Decatur, GA United States

Kristi George

Josephson, Wallack, Munshower Neurology, PC
Indianapolis, IN United States

Brent Forester

McLean Hospital
Belmont, MA United States

Paul Solomon

Boston Center for Memory
Newton, MA United States

Ronald Schwartz

Hattiesburg Clinic, PA
Hattiesburg, MS United States

Charles Bernick

Cleveland Clinic Lou Ruvo Center for Brain Health
Las Vegas, NV United States

Marc Shay

ActivMed Practices & Research
Portsmouth, NH United States

Arnold Witte

AdvanceMed Research
Lawrenceville, NJ United States

Keith Edwards

Empire Neurology, PC
Latham, NY United States

Michael Lin

Weill Cornell Medical College-New York Presbyterian Hospital
New York, NY United States

Amy Aloysi

Mount Sinai School of Medicine
New York, NY United States

Giles Crowell

PMG Research of Winston-Salem, LLC
Winston-Salem, NC United States

Kaycee Sink

Wake Forest Baptist Health
Winston-Salem, NC United States

Douglas Scharre

Ohio State University Medical Center
Dublin, OH United States

Paul Gross

Lehigh Center for Clinical Research, LLC
Allentown, PA United States

David Wolk

Penn Memory Center
Philadelphia, PA United States

Brian Ott

Rhode Island Hospital
Providence, RI United States

Jacobo Mintzer

Roper St. Francis Healthcare
North Charleston, SC United States

Jaron Winston

Senior Adult Specialty Research
Austin, TX United States

Joseph Masdeu

The Methodist Hospital Research Institute
Houston, TX United States

Djamchid Lotfi

Clinical Trial Network
Houston, TX United States

Richard King

University of Utah Health Sciences Center
Salt Lake City, UT United States

Cynthia Murphy

Clinical Neuroscience Research Association, Inc
Bennington, VT United States

Suman Jayadev

University of Washington Medical Center
Seattle, WA United States

David Greeley

Northwest Neurological, PLLC
Spokane, WA United States

Aducanumab Global Clinical Trial Center

AZ Sint-Jan Brugge
Brugge, Belgium

Versijpt

Universitair Ziekenhuis Brussel
Bruxelles, Belgium

Guillaume

Centre Neurologique & de R adaptation Fonctionnelle
Fraiture-en-Condroz, Belgium

Aducanumab Global Clinical Trial Center

Universitair Ziekenhuis Gent
Gent, Belgium

Aducanumab Global Clinical Trial Center

AZ Groeninge - Campus Kennedylaan
Kortrijk, Belgium

Rik Vandenberghe

UZ Leuven
Leuven, Belgium

Dr. Philip Bourgeois

AZ Delta
Roeselare, Belgium

Aducanumab Global Clinical Trial Center

Health Research.
Kamloops, BC Canada

Aducanumab Global Clinical Trial Center

Health Research
West Vancouver, BC Canada

Aducanumab Global Clinical Trial Center

True North Clinical Research - Halifax Inc.
Halifax, NS Canada

Aducanumab Global Clinical Trial Center

True North Clinical Research Kentville, Inc
Kentville, NS Canada

Aducanumab Global Clinical Trial Center

JBN Medical Diagnostic Services Inc.
Burlington, ON Canada

Aducanumab Global Clinical Trial Center

St. Joseph's HC- Parkwood Institute
London, ON Canada

Aducanumab Global Clinical Trial Center

Bruyere Continuing Care
Ottawa, ON Canada

Aducanumab Global Clinical Trial Center

Kawartha Regional Memory Clinic
Peterborough, ON Canada

Aducanumab Global Clinical Trial Center

Toronto Western Hospital
Toronto, ON Canada

Aducanumab Global Clinical Trial Center

Recherches Neuro-Hippocampe Inc.
Gatineau, QC Canada

Aducanumab Global Clinical Trial Center

Recherche Sepmus, Inc.
Greenfield Park, QC Canada

Aducanumab Global Clinical Trial Center

Jewish General Hospital - NETWORK
Montreal, QC Canada

Aducanumab Global Clinical Trial Center

DIEX Recherche Sherbrooke Inc.
Sherbrooke, QC Canada

Aducanumab Global Clinical Trial Center

Douglas Hospital Research Centre
Verdun, QC Canada

Aducanumab Global Clinical Trial Center

Terveystalo Kamppi
Helsinki, Finland

Merja Hallikainen

It -Suomen yliopisto, Aivotutkimusyksikk
Kuopio, Finland

Aducanumab Global Clinical Trial Center

CRST, Clinical Research Services Turku
Turku, Finland

Ceccaldi

H pital de la Timone
Marseille, France

Jeremie Pr Pariente

CHU de Toulouse - H pital Purpan
Toulouse cedex 9, France

Vellas

Centre de Recherche Clinique du G rontop le - Cit de la Sant
Toulouse, France

Dr. Karim Bennys

H pital Gui de Chauliac
Montpellier, France

Aducanumab Global Clinical Trial Center

CHU Rennes - Hopital Pontchaillou
Rennes cedex 09, France

Aducanumab Global Clinical Trial Center

CHU Nantes - Hopital Nord La nnec
Nantes cedex 1, France

Florence Pasquier

Hopital Roger Salengro - CHU Lille
Lille Cedex, France

Pr Krolak-Salmon

H pital des Charpennes
Villeurbanne, France

Jacques Hugon

H pital Fernand Widal
Paris, France

Aducanumab Global Clinical Trial Center

Bezirkskrankenhaus Guenzburg
Guenzburg, Germany

Aducanumab Global Clinical Trial Center

ISPG - Institut fuer Studien zur Psychischen Gesundheit
Mannheim, Germany

Aducanumab Global Clinical Trial Center

Nervenfachaerztlichen Gemeinschaftspraxis Ulm
Ulm, Germany

Aducanumab Global Clinical Trial Center

Universitaetsklinikum Ulm
Ulm, Germany

Aducanumab Global Clinical Trial Center

Klinik Hohe Warte Bayreuth
Bayreuth, Germany

Aducanumab Global Clinical Trial Center

Institut fuer Schlaganfall- und Demenzforschung (ISD)
Muenchen, Germany

Aducanumab Global Clinical Trial Center

Klinikum rechts der Isar der TU Muenchen
Muenchen, Germany

Aducanumab Global Clinical Trial Center

Neuropraxis Muenchen Sued
Unterhaching, Germany

Aducanumab Global Clinical Trial Center

Praxis Dr. Kluenemann
Wenzenbach, Germany

Aducanumab Global Clinical Trial Center

Neuro Centrum Odenwald
Erbach, Germany

Aducanumab Global Clinical Trial Center

Schwerpunktpraxis fuer Neurologie, Psychiatrie und Klinische Studien
Bielefeld, Germany

Aducanumab Global Clinical Trial Center

Universitaetsklinikum Duesseldorf AoeR
Duesseldorf, Germany

Aducanumab Global Clinical Trial Center

Universitaetsklinikum Muenster
Muenster, Germany

Aducanumab Global Clinical Trial Center

Zentrum f. Neurologisch- Psychiatrische Studien und Begutachtung
Siegen, Germany

Aducanumab Global Clinical Trial Center

Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz
Mainz, Germany

Aducanumab Global Clinical Trial Center

Klinikum Chemnitz gGmbH
Chemnitz, Germany

Aducanumab Global Clinical Trial Center

Kopfzentrum Leipzig
Leipzig, Germany

Aducanumab Global Clinical Trial Center

Klinikum Altenburger Land GmbH
Altenburg, Germany

Aducanumab Global Clinical Trial Center

emovis GmbH
Berlin, Germany

Isabella Lemonnier

Neurologie im Tempelhofer Hafen
Berlin, Germany

Aducanumab Global Clinical Trial Center

Ospedale degli Infermi
Ponderano, Italy

Aducanumab Global Clinical Trial Center

Azienda Ospedaliera Card. G. Panico
Tricase, Italy

Aducanumab Global Clinical Trial Center

ASST di Monza
Monza, Italy

Aducanumab Global Clinical Trial Center

Fondazione IRCCS Istituto Neurologico Carlo Besta
Milano, Italy

Aducanumab Global Clinical Trial Center

Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone
Palermo, Italy

Aducanumab Global Clinical Trial Center

Azienda Ospedaliera di Perugia Ospedale S. Maria della Misericordia
Perugia, Italy

Aducanumab Global Clinical Trial Center

Fondazione Santa Lucia IRCCS
Roma, Italy

Aducanumab Global Clinical Trial Center

Umberto I Pol. di Roma-Universit di Roma La Sapienza
Roma, Italy

Aducanumab Global Clinical Trial Center

Research Site
Obu-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Toon-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Fukuoka-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Kurume-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Otake-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Amagasaki-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Himeji-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Kobe-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Kita-gun, Japan

Aducanumab Global Clinical Trial Center

Research Site
Kyoto-shi, Japan

Kimiko Yoshimaru

Research Site
Tsu-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Nishisonogi-gun, Japan

Aducanumab Global Clinical Trial Center

Research Site
Yufu-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Kurashiki-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Okayama-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Tsukubo-Gun, Japan

Aducanumab Global Clinical Trial Center

Research Site
Kishiwada-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Osaka-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Sennan-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Suita-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Toyonaka-Shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Hamamatsu-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Iwata-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Shizuoka-shi, Japan

Kim Verheul

Alzheimer Research Center
Amsterdam, Netherlands

Dr. A. van Norden

Amphia Ziekenhuis
Breda, Netherlands

Aducanumab Global Clinical Trial Center

Kennemer Gasthuis, Zuid
Haarlem, Netherlands

Aducanumab Global Clinical Trial Center

Erasmus Medisch Centrum
Rotterdam, Netherlands

Aducanumab Global Clinical Trial Center

Podlaskie Centrum Psychogeriatrii
Bialystok, Poland

Aducanumab Global Clinical Trial Center

PALLMED Sp. z o.o.
Bydgoszcz, Poland

Aducanumab Global Clinical Trial Center

COPERNICUS Podmiot Leczniczy Sp. z o. o.,
Gdansk, Poland

Aducanumab Global Clinical Trial Center

Uniwersyteckie Centrum Kliniczne
Gdansk, Poland

Aducanumab Global Clinical Trial Center

Novo-Med Zielinski i wspolnicy Sp. j.
Katowice, Poland

Aducanumab Global Clinical Trial Center

Neuro-Care Site Management Organization Gabriela Klodowska-Duda
Katowice, Poland

Aducanumab Global Clinical Trial Center

SPZOZ Szpital Uniwersytecki w Krakowie
Krakow, Poland

Aducanumab Global Clinical Trial Center

SPZOZ Centralny Szpital Kliniczny UM w Lodzi
Lodz, Poland

Aducanumab Global Clinical Trial Center

Centrum Diagnostyczno - Terapeutyczne "MEDICUS" Sp.z o.o.
Lubin, Poland

Aducanumab Global Clinical Trial Center

Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie
Lublin, Poland

Aducanumab Global Clinical Trial Center

Neurologiczny NZOZ Centrum Leczenia SM
Plewiska, Poland

Aducanumab Global Clinical Trial Center

NZOZ "NEURO-KARD", "Ilkowski i Partnerzy" Sp. Partn. Lek.
Poznan, Poland

Aducanumab Global Clinical Trial Center

Centrum Medyczne Medyk
Rzeszow, Poland

Aducanumab Global Clinical Trial Center

NZOZ "SENIOR" Poradnia Psychogeriatryczna
Sopot, Poland

Aducanumab Global Clinical Trial Center

Osrodek Badan Klinicznych EUROMEDIS
Szczecin, Poland

Aducanumab Global Clinical Trial Center

mMED Maciej Czarnecki
Warszawa, Poland

Aducanumab Global Clinical Trial Center

Centralny Szpital Kliniczny MSW w Warszawie
Warszawa, Poland

Aducanumab Global Clinical Trial Center

Wojewodzki Szpital Specjalistyczny we Wroclawiu
Wroclaw, Poland

Aducanumab Global Clinical Trial Center

Hospital General Universitario de Elche
Elche, Spain

Aducanumab Global Clinical Trial Center

ALTHAIA Hospital Sant Joan de Deu
Manresa, Spain

Aducanumab Global Clinical Trial Center

Complejo Hospitalario de Caceres
Caceres, Spain

Aducanumab Global Clinical Trial Center

Hospital Universitario Reina Sof a
Cordoba, Spain

Mario Riverol

Clinica Universidad de Navarra
Pamplona, Spain

Aducanumab Global Clinical Trial Center

Hospital de Basurto
Bilbao, Spain

Aducanumab Global Clinical Trial Center

Hospital del Mar
Barcelona, Spain

Aducanumab Global Clinical Trial Center

Hospital Universitari Quiron Dexeus
Barcelona, Spain

Aducanumab Global Clinical Trial Center

Hospital Universitari de Bellvitge
Barcelona, Spain

Aducanumab Global Clinical Trial Center

Hospital Universitari Arnau de Vilanova
Lleida, Spain

Aducanumab Global Clinical Trial Center

Hospital Universitario de La Princesa
Madrid, Spain

Aducanumab Global Clinical Trial Center

Hospital Universitario Virgen Macarena
Sevilla, Spain

Niels Andreasen

Karolinska Universitetssjukhuset, Huddinge
Stockholm, Sweden

Aducanumab Global Clinical Trial Center

Akademiska Sjukhuset
Uppsala, Sweden

Aducanumab Global Clinical Trial Center

Universit ren Psychiatrischen Kliniken Basel (UPK)
Basel, Switzerland

Aducanumab Global Clinical Trial Center

Inselspital - Universitaetsspital Bern
Bern, Switzerland

Aducanumab Global Clinical Trial Center

Medizinisches Zentrum MZB Biel
Biel/Bienne, Switzerland

Aducanumab Global Clinical Trial Center

H pitaux Universitaires de Gen ve - HUG
Geneve 14, Switzerland

Prof. Jean-Francois Demonet

Centre Hospitalier Universitaire Vaudois
Lausanne, Switzerland

Aducanumab Global Clinical Trial Center

Ospedale Civico
Lugano, Switzerland

Aducanumab Global Clinical Trial Center

Institut fuer Regenerative Medizin (IREM) der Universitaet Zuerich, Zentrum fuer Praevention und Demenztherapie
Schlieren, Switzerland

Karine Geens

A.Z. Klina
Brasschaat, Belgium

Aducanumab Global Clinical Trial Center

Sk nes Universitetssjukhus, Malm
Malmö, Sweden

Aducanumab Global Clinical Trial Center

Sahlgrenska Universitetssjukhuset, M lndal Sjukhus
Mölndal, Sweden