Last updated on May 2018

221AD302 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer's Disease


Brief description of study

The primary objective of the study is to evaluate the efficacy of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the Clinical Dementia Rating-Sum of Boxes (CDR-SB) score as compared with placebo in participants with early AD. Secondary objectives are to assess the effect of monthly doses of aducanumab as compared with placebo on clinical progression as measured by Mini-Mental State Examination (MMSE), AD Assessment Scale-Cognitive Subscale (13 items) [ADAS-Cog 13], and AD Cooperative Study-Activities of Daily Living Inventory (Mild Cognitive Impairment version) [ADCS-ADL-MCI].

Clinical Study Identifier: NCT02484547

Contact Investigators or Research Sites near you

Start Over

David Geldmacher

University of Alabama at Birmingham
Birmingham, AL United States
  Connect »

David Weidman

Banner Alzheimer's Institute
Phoenix, AZ United States
  Connect »

Stephen Flitman

Xenoscience Inc.
Phoenix, AZ United States
  Connect »

Edward Zamrini

Banner Sun Health Research Institute
Sun City, AZ United States
  Connect »

Aimee Pierce

Institute for Memory Impairments
Irvine, CA United States
  Connect »

Laja Ibraheem

Renewal Behavioral Health
Long Beach, CA United States
  Connect »

Lon Schneider

USC Keck School of Medicine
Los Angeles, CA United States
  Connect »

William Shankle

Hoag Memorial Hospital Presbyterian
Newport Beach, CA United States
  Connect »

Sheryy Soefje

Excell Research, Inc.
Oceanside, CA United States
  Connect »

James Sutton

Pacific Neuroscience Medical Group
Oxnard, CA United States
  Connect »

Donald Anderson

Anderson Clinical Research
Redlands, CA United States
  Connect »

Stephen Thein

Pacific Research Network
San Diego, CA United States
  Connect »

James Lohr

University of California San Diego Medical Center
San Diego, CA United States
  Connect »

Alireza Atri

California Pacific Medical Center
San Francisco, CA United States
  Connect »

John Duffy

Syrentis Clinical Research
Santa Ana, CA United States
  Connect »

Marc Bernstein

St Joseph Heritage Healthcare
Santa Rosa, CA United States
  Connect »

Sharon Sha

Stanford University Medical Center
Stanford, CA United States
  Connect »

Jonathan Woodcock

University Of Colorado Denver
Aurora, CO United States
  Connect »

Ronald Murray

IMMUNOe International Research Centers
Thornton, CO United States
  Connect »

Dario Zagar

Associated Neurologists of Southern Connecticut, PC
Fairfield, CT United States
  Connect »

Christopher Van Dyck

Yale University School Of Medicine
New Haven, CT United States
  Connect »

Bart Sloan

Research Center for Clinical Studies, Inc.
Norwalk, CT United States
  Connect »

Mark Goldstein

JEM Research Institute
Atlantis, FL United States
  Connect »

James Galvin

Florida Atlantic University
Boca Raton, FL United States
  Connect »

William McElveen

Bradenton Research Center, Inc.
Bradenton, FL United States
  Connect »

Kelli Max

Meridien Research
Brooksville, FL United States
  Connect »

Jose De La Gandara

Quantum Laboratories Inc.
Deerfield Beach, FL United States
  Connect »

Harvey Schwartz

Infinity Clinical Research, LLC
Hollywood, FL United States
  Connect »

Neill Graff-Radford

Mayo Clinic in Florida
Jacksonville, FL United States
  Connect »

Jay Rubin

Renstar Medical Research
Ocala, FL United States
  Connect »

Linda Harper

Clinical Neuroscience Solutions, Inc.
Orlando, FL United States
  Connect »

Susan Steen

Axiom Clinical Research of Florida
Tampa, FL United States
  Connect »

Allan Levey

Emory University Cognitive Neurology Clinic & ADRC
Atlanta, GA United States
  Connect »

Jonathan Liss

Medical Research Health and Education Foundation, Inc
Columbus, GA United States
  Connect »

Marshall Nash

NeuroStudies.net, LLC
Decatur, GA United States
  Connect »

Kristi George

Josephson, Wallack, Munshower Neurology, PC
Indianapolis, IN United States
  Connect »

Brent Forester

McLean Hospital
Belmont, MA United States
  Connect »

Paul Solomon

Boston Center for Memory
Newton, MA United States
  Connect »

Ronald Schwartz

Hattiesburg Clinic, PA
Hattiesburg, MS United States
  Connect »

Charles Bernick

Cleveland Clinic Lou Ruvo Center for Brain Health
Las Vegas, NV United States
  Connect »

Marc Shay

ActivMed Practices & Research
Portsmouth, NH United States
  Connect »

Arnold Witte

AdvanceMed Research
Lawrenceville, NJ United States
  Connect »

Keith Edwards

Empire Neurology, PC
Latham, NY United States
  Connect »

Michael Lin

Weill Cornell Medical College-New York Presbyterian Hospital
New York, NY United States
  Connect »

Amy Aloysi

Mount Sinai School of Medicine
New York, NY United States
  Connect »

Giles Crowell

PMG Research of Winston-Salem, LLC
Winston-Salem, NC United States
  Connect »

Kaycee Sink

Wake Forest Baptist Health
Winston-Salem, NC United States
  Connect »

Douglas Scharre

Ohio State University Medical Center
Dublin, OH United States
  Connect »

Paul Gross

Lehigh Center for Clinical Research, LLC
Allentown, PA United States
  Connect »

David Wolk

Penn Memory Center
Philadelphia, PA United States
  Connect »

Brian Ott

Rhode Island Hospital
Providence, RI United States
  Connect »

Jacobo Mintzer

Roper St. Francis Healthcare
North Charleston, SC United States
  Connect »

Jaron Winston

Senior Adult Specialty Research
Austin, TX United States
  Connect »

Joseph Masdeu

The Methodist Hospital Research Institute
Houston, TX United States
  Connect »

Djamchid Lotfi

Clinical Trial Network
Houston, TX United States
  Connect »

Richard King

University of Utah Health Sciences Center
Salt Lake City, UT United States
  Connect »

Cynthia Murphy

Clinical Neuroscience Research Association, Inc
Bennington, VT United States
  Connect »

Suman Jayadev

University of Washington Medical Center
Seattle, WA United States
  Connect »

David Greeley

Northwest Neurological, PLLC
Spokane, WA United States
  Connect »

Aducanumab Global Clinical Trial Center

AZ Sint-Jan Brugge
Brugge, Belgium
  Connect »

Versijpt

Universitair Ziekenhuis Brussel
Bruxelles, Belgium
  Connect »

Guillaume

Centre Neurologique & de R adaptation Fonctionnelle
Fraiture-en-Condroz, Belgium
  Connect »

Aducanumab Global Clinical Trial Center

Universitair Ziekenhuis Gent
Gent, Belgium
  Connect »

Aducanumab Global Clinical Trial Center

AZ Groeninge - Campus Kennedylaan
Kortrijk, Belgium
  Connect »

Rik Vandenberghe

UZ Leuven
Leuven, Belgium
  Connect »

Dr. Philip Bourgeois

AZ Delta
Roeselare, Belgium
  Connect »

Aducanumab Global Clinical Trial Center

Health Research.
Kamloops, BC Canada
  Connect »

Aducanumab Global Clinical Trial Center

Health Research
West Vancouver, BC Canada
  Connect »

Aducanumab Global Clinical Trial Center

True North Clinical Research - Halifax Inc.
Halifax, NS Canada
  Connect »

Aducanumab Global Clinical Trial Center

True North Clinical Research Kentville, Inc
Kentville, NS Canada
  Connect »

Aducanumab Global Clinical Trial Center

JBN Medical Diagnostic Services Inc.
Burlington, ON Canada
  Connect »

Aducanumab Global Clinical Trial Center

St. Joseph's HC- Parkwood Institute
London, ON Canada
  Connect »

Aducanumab Global Clinical Trial Center

Bruyere Continuing Care
Ottawa, ON Canada
  Connect »

Aducanumab Global Clinical Trial Center

Kawartha Regional Memory Clinic
Peterborough, ON Canada
  Connect »

Aducanumab Global Clinical Trial Center

Toronto Western Hospital
Toronto, ON Canada
  Connect »

Aducanumab Global Clinical Trial Center

Recherches Neuro-Hippocampe Inc.
Gatineau, QC Canada
  Connect »

Aducanumab Global Clinical Trial Center

Recherche Sepmus, Inc.
Greenfield Park, QC Canada
  Connect »

Aducanumab Global Clinical Trial Center

Jewish General Hospital - NETWORK
Montreal, QC Canada
  Connect »

Aducanumab Global Clinical Trial Center

DIEX Recherche Sherbrooke Inc.
Sherbrooke, QC Canada
  Connect »

Aducanumab Global Clinical Trial Center

Douglas Hospital Research Centre
Verdun, QC Canada
  Connect »

Aducanumab Global Clinical Trial Center

Terveystalo Kamppi
Helsinki, Finland
  Connect »

Merja Hallikainen

It -Suomen yliopisto, Aivotutkimusyksikk
Kuopio, Finland
  Connect »

Aducanumab Global Clinical Trial Center

CRST, Clinical Research Services Turku
Turku, Finland
  Connect »

Ceccaldi

H pital de la Timone
Marseille, France
  Connect »

Jeremie Pr Pariente

CHU de Toulouse - H pital Purpan
Toulouse cedex 9, France
  Connect »

Vellas

Centre de Recherche Clinique du G rontop le - Cit de la Sant
Toulouse, France
  Connect »

Dr. Karim Bennys

H pital Gui de Chauliac
Montpellier, France
  Connect »

Aducanumab Global Clinical Trial Center

CHU Rennes - Hopital Pontchaillou
Rennes cedex 09, France
  Connect »

Aducanumab Global Clinical Trial Center

CHU Nantes - Hopital Nord La nnec
Nantes cedex 1, France
  Connect »

Florence Pasquier

Hopital Roger Salengro - CHU Lille
Lille Cedex, France
  Connect »

Pr Krolak-Salmon

H pital des Charpennes
Villeurbanne, France
  Connect »

Jacques Hugon

H pital Fernand Widal
Paris, France
  Connect »

Aducanumab Global Clinical Trial Center

Bezirkskrankenhaus Guenzburg
Guenzburg, Germany
  Connect »

Aducanumab Global Clinical Trial Center

ISPG - Institut fuer Studien zur Psychischen Gesundheit
Mannheim, Germany
  Connect »

Aducanumab Global Clinical Trial Center

Nervenfachaerztlichen Gemeinschaftspraxis Ulm
Ulm, Germany
  Connect »

Aducanumab Global Clinical Trial Center

Universitaetsklinikum Ulm
Ulm, Germany
  Connect »

Aducanumab Global Clinical Trial Center

Klinik Hohe Warte Bayreuth
Bayreuth, Germany
  Connect »

Aducanumab Global Clinical Trial Center

Institut fuer Schlaganfall- und Demenzforschung (ISD)
Muenchen, Germany
  Connect »

Aducanumab Global Clinical Trial Center

Klinikum rechts der Isar der TU Muenchen
Muenchen, Germany
  Connect »

Aducanumab Global Clinical Trial Center

Neuropraxis Muenchen Sued
Unterhaching, Germany
  Connect »

Aducanumab Global Clinical Trial Center

Praxis Dr. Kluenemann
Wenzenbach, Germany
  Connect »

Aducanumab Global Clinical Trial Center

Neuro Centrum Odenwald
Erbach, Germany
  Connect »

Aducanumab Global Clinical Trial Center

Schwerpunktpraxis fuer Neurologie, Psychiatrie und Klinische Studien
Bielefeld, Germany
  Connect »

Aducanumab Global Clinical Trial Center

Universitaetsklinikum Duesseldorf AoeR
Duesseldorf, Germany
  Connect »

Aducanumab Global Clinical Trial Center

Universitaetsklinikum Muenster
Muenster, Germany
  Connect »

Aducanumab Global Clinical Trial Center

Zentrum f. Neurologisch- Psychiatrische Studien und Begutachtung
Siegen, Germany
  Connect »

Aducanumab Global Clinical Trial Center

Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz
Mainz, Germany
  Connect »

Aducanumab Global Clinical Trial Center

Klinikum Chemnitz gGmbH
Chemnitz, Germany
  Connect »

Aducanumab Global Clinical Trial Center

Kopfzentrum Leipzig
Leipzig, Germany
  Connect »

Aducanumab Global Clinical Trial Center

Klinikum Altenburger Land GmbH
Altenburg, Germany
  Connect »

Isabella Lemonnier

Neurologie im Tempelhofer Hafen
Berlin, Germany
  Connect »

Aducanumab Global Clinical Trial Center

Ospedale degli Infermi
Ponderano, Italy
  Connect »

Aducanumab Global Clinical Trial Center

Azienda Ospedaliera Card. G. Panico
Tricase, Italy
  Connect »

Aducanumab Global Clinical Trial Center

Fondazione IRCCS Istituto Neurologico Carlo Besta
Milano, Italy
  Connect »

Aducanumab Global Clinical Trial Center

Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone
Palermo, Italy
  Connect »

Aducanumab Global Clinical Trial Center

Azienda Ospedaliera di Perugia Ospedale S. Maria della Misericordia
Perugia, Italy
  Connect »

Aducanumab Global Clinical Trial Center

Fondazione Santa Lucia IRCCS
Roma, Italy
  Connect »

Aducanumab Global Clinical Trial Center

Umberto I Pol. di Roma-Universit di Roma La Sapienza
Roma, Italy
  Connect »

Aducanumab Global Clinical Trial Center

Research Site
Amagasaki-shi, Japan
  Connect »

Kimiko Yoshimaru

Research Site
Tsu-shi, Japan
  Connect »

Aducanumab Global Clinical Trial Center

Research Site
Nishisonogi-gun, Japan
  Connect »

Aducanumab Global Clinical Trial Center

Research Site
Kurashiki-shi, Japan
  Connect »

Aducanumab Global Clinical Trial Center

Research Site
Kishiwada-shi, Japan
  Connect »

Aducanumab Global Clinical Trial Center

Research Site
Toyonaka-Shi, Japan
  Connect »

Aducanumab Global Clinical Trial Center

Research Site
Hamamatsu-shi, Japan
  Connect »

Aducanumab Global Clinical Trial Center

Research Site
Shizuoka-shi, Japan
  Connect »

Kim Verheul

Alzheimer Research Center
Amsterdam, Netherlands
  Connect »

Dr. A. van Norden

Amphia Ziekenhuis
Breda, Netherlands
  Connect »

Aducanumab Global Clinical Trial Center

Kennemer Gasthuis, Zuid
Haarlem, Netherlands
  Connect »

Aducanumab Global Clinical Trial Center

Erasmus Medisch Centrum
Rotterdam, Netherlands
  Connect »

Aducanumab Global Clinical Trial Center

Podlaskie Centrum Psychogeriatrii
Bialystok, Poland
  Connect »

Aducanumab Global Clinical Trial Center

PALLMED Sp. z o.o.
Bydgoszcz, Poland
  Connect »

Aducanumab Global Clinical Trial Center

COPERNICUS Podmiot Leczniczy Sp. z o. o.,
Gdansk, Poland
  Connect »

Aducanumab Global Clinical Trial Center

Uniwersyteckie Centrum Kliniczne
Gdansk, Poland
  Connect »

Aducanumab Global Clinical Trial Center

Novo-Med Zielinski i wspolnicy Sp. j.
Katowice, Poland
  Connect »

Aducanumab Global Clinical Trial Center

Neuro-Care Site Management Organization Gabriela Klodowska-Duda
Katowice, Poland
  Connect »

Aducanumab Global Clinical Trial Center

SPZOZ Szpital Uniwersytecki w Krakowie
Krakow, Poland
  Connect »

Aducanumab Global Clinical Trial Center

SPZOZ Centralny Szpital Kliniczny UM w Lodzi
Lodz, Poland
  Connect »

Aducanumab Global Clinical Trial Center

Centrum Diagnostyczno - Terapeutyczne "MEDICUS" Sp.z o.o.
Lubin, Poland
  Connect »

Aducanumab Global Clinical Trial Center

Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie
Lublin, Poland
  Connect »

Aducanumab Global Clinical Trial Center

Neurologiczny NZOZ Centrum Leczenia SM
Plewiska, Poland
  Connect »

Aducanumab Global Clinical Trial Center

NZOZ "NEURO-KARD", "Ilkowski i Partnerzy" Sp. Partn. Lek.
Poznan, Poland
  Connect »

Aducanumab Global Clinical Trial Center

Centrum Medyczne Medyk
Rzeszow, Poland
  Connect »

Aducanumab Global Clinical Trial Center

NZOZ "SENIOR" Poradnia Psychogeriatryczna
Sopot, Poland
  Connect »

Aducanumab Global Clinical Trial Center

Osrodek Badan Klinicznych EUROMEDIS
Szczecin, Poland
  Connect »

Aducanumab Global Clinical Trial Center

mMED Maciej Czarnecki
Warszawa, Poland
  Connect »

Aducanumab Global Clinical Trial Center

Centralny Szpital Kliniczny MSW w Warszawie
Warszawa, Poland
  Connect »

Aducanumab Global Clinical Trial Center

Wojewodzki Szpital Specjalistyczny we Wroclawiu
Wroclaw, Poland
  Connect »

Aducanumab Global Clinical Trial Center

Hospital General Universitario de Elche
Elche, Spain
  Connect »

Aducanumab Global Clinical Trial Center

ALTHAIA Hospital Sant Joan de Deu
Manresa, Spain
  Connect »

Aducanumab Global Clinical Trial Center

Complejo Hospitalario de Caceres
Caceres, Spain
  Connect »

Aducanumab Global Clinical Trial Center

Hospital Universitario Reina Sof a
Cordoba, Spain
  Connect »

Mario Riverol

Clinica Universidad de Navarra
Pamplona, Spain
  Connect »

Aducanumab Global Clinical Trial Center

Hospital de Basurto
Bilbao, Spain
  Connect »

Aducanumab Global Clinical Trial Center

Hospital del Mar
Barcelona, Spain
  Connect »

Aducanumab Global Clinical Trial Center

Hospital Universitari Quiron Dexeus
Barcelona, Spain
  Connect »

Aducanumab Global Clinical Trial Center

Hospital Universitari de Bellvitge
Barcelona, Spain
  Connect »

Aducanumab Global Clinical Trial Center

Hospital Universitari Arnau de Vilanova
Lleida, Spain
  Connect »

Aducanumab Global Clinical Trial Center

Hospital Universitario de La Princesa
Madrid, Spain
  Connect »

Aducanumab Global Clinical Trial Center

Hospital Universitario Virgen Macarena
Sevilla, Spain
  Connect »

Niels Andreasen

Karolinska Universitetssjukhuset, Huddinge
Stockholm, Sweden
  Connect »

Aducanumab Global Clinical Trial Center

Akademiska Sjukhuset
Uppsala, Sweden
  Connect »

Aducanumab Global Clinical Trial Center

Universit ren Psychiatrischen Kliniken Basel (UPK)
Basel, Switzerland
  Connect »

Aducanumab Global Clinical Trial Center

Inselspital - Universitaetsspital Bern
Bern, Switzerland
  Connect »

Aducanumab Global Clinical Trial Center

Medizinisches Zentrum MZB Biel
Biel/Bienne, Switzerland
  Connect »

Aducanumab Global Clinical Trial Center

H pitaux Universitaires de Gen ve - HUG
Geneve 14, Switzerland
  Connect »

Prof. Jean-Francois Demonet

Centre Hospitalier Universitaire Vaudois
Lausanne, Switzerland
  Connect »

Aducanumab Global Clinical Trial Center

Ospedale Civico
Lugano, Switzerland
  Connect »

Aducanumab Global Clinical Trial Center

Institut fuer Regenerative Medizin (IREM) der Universitaet Zuerich, Zentrum fuer Praevention und Demenztherapie
Schlieren, Switzerland
  Connect »

Karine Geens

A.Z. Klina
Brasschaat, Belgium
  Connect »

Aducanumab Global Clinical Trial Center

Sk nes Universitetssjukhus, Malm
Malmö, Sweden
  Connect »

Aducanumab Global Clinical Trial Center

Sahlgrenska Universitetssjukhuset, M lndal Sjukhus
Mölndal, Sweden
  Connect »