Last updated on August 2018

221AD301 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer's Disease


Brief description of study

The primary objective of the study is to evaluate the efficacy of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the Clinical Dementia Rating-Sum of Boxes (CDR-SB) score as compared with placebo in participants with early AD. Secondary objectives are to assess the effect of monthly doses of aducanumab as compared with placebo on clinical progression as measured by Mini-Mental State Examination (MMSE), AD Assessment Scale-Cognitive Subscale (13 items) [ADAS-Cog 13], and AD Cooperative Study-Activities of Daily Living Inventory (Mild Cognitive Impairment version) [ADCS-ADL-MCI].

Clinical Study Identifier: NCT02477800

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Jiong Shi

St. Joseph's Hospital and Medical Center
Phoenix, AZ United States

Michael Badruddoja

Center for Neurosciences
Tucson, AZ United States

Anthony Ciabarra

Neurology Center of North Orange County
Fullerton, CA United States

Robert Feldman

Senior Clinical Trials, Inc.
Laguna Hills, CA United States

Aducanumab Global Clinical Trial Center

Torrance Clinical Research Institute, Inc.
Lomita, CA United States

Sarah Kremen

University of California - Los Angeles
Los Angeles, CA United States

Adam Boxer

UCSF - Memory and Aging Center
San Francisco, CA United States

Thomas Shiovitz

California Neuroscience Research Medical Group Inc.
Sherman Oaks, CA United States

Brock Summers

Southern California Research LLC
Simi Valley, CA United States

David Russell

Institute for Neurodegenerative Disorders
New Haven, CT United States

Mark Brody

Brain Matters Research, Inc.
Delray Beach, FL United States

Frederick Schaerf

Neuropsychiatric Research Center of Southwest Florida
Fort Myers, FL United States

Erin Doty

Jacksonville Center for Clinical Research
Jacksonville, FL United States

Barry Baumel

University of Miami
Miami, FL United States

Marc Agronin

Miami Jewish Health Systems
Miami, FL United States

Aducanumab Global Clinical Trial Center

New Horizon Research Center, Inc
Miami, FL United States

Craig Curtis

Compass Research Main
Orlando, FL United States

Michael Tuchman

Palm Beach Neurological Center
Palm Beach Gardens, FL United States

Mary Stedman

Stedman Clinical Trials, LLC
Tampa, FL United States

Amanda Smith

USF Health Byrd Institute
Tampa, FL United States

Cynthia Huffman

Meridien Research
Tampa, FL United States

David Subich

Compass Research Main
The Villages, FL United States

Walter Martinez

Premiere Research Institute
West Palm Beach, FL United States

Po-Heng Tsai

Cleveland Clinic Florida - Weston
Weston, FL United States

Aducanumab Global Clinical Trial Center

MS Center of Atlanta
Atlanta, GA United States

Concetta Forchetti

Alexian Brothers Neurosciences Institute
Elk Grove Village, IL United States

Darren Gitelman

Advocate Lutheran General Hospital
Park Ridge, IL United States

James Stevens

Fort Wayne Neurological Center
Fort Wayne, IN United States

Martin Farlow

Indiana University School of Medicine
Indianapolis, IN United States

Jeffrey Burns

University of Kansas Medical Center Research Institute, Inc.
Kansas City, KS United States

Paul Murphy

Via Christi Research, a division of Via Christi Hospitals Wichita, Inc.
Wichita, KS United States

Gregory Cooper

Baptist Health Lexington
Lexington, KY United States

Scott McGinnis

Brigham & Women's Hosp End/Dbt
Boston, MA United States

Henry Querfurth

Beth Israel Deaconess Medical Center
Boston, MA United States

Michael McCartney

ActivMed Practices & Research
Methuen, MA United States

Donald Marks

Donald S. Marks, M.D., P.C.
Plymouth, MA United States

David Knopman

Mayo Clinic
Rochester, MN United States

Barbara Snider

Washington University
Saint Louis, MO United States

Bharat Mocherla

Las Vegas Medical research
Las Vegas, NV United States

Sanjiv Sharma

Advanced Memory Research Institute of NJ, PC
Toms River, NJ United States

Earl Zimmerman

Albany Medical College
Albany, NY United States

Martin Sadowski

New York University Medical Center PRIME
New York, NY United States

Anton Porsteinsson

University of Rochester
Rochester, NY United States

Mohammad Bolouri

ANI Neurology, PLLC d/b/a Alzheimer's Memory Center
Charlotte, NC United States

Michael Bowman

Raleigh Neurology Associates, P.A.
Raleigh, NC United States

Babak Tousi

Cleveland Clinic
Cleveland, OH United States

Carl Griffin

Lynn Health Science Institute
Oklahoma City, OK United States

Marvin Kalafer

The Clinical Trial Center, LLC
Jenkintown, PA United States

Oscar Lopez

University of Pittsburgh
Pittsburgh, PA United States

Mario Cornacchione

Northeastern Pennsylvania Memory and Alzheimer's Center
Plains, PA United States

John Stoukides

Rhode Island Mood & Memory Research Institute
East Providence, RI United States

Stephen Salloway

Butler Hospital
Providence, RI United States

David Clark

Medical University of South Carolina (MUSC)
Charleston, SC United States

Lee Stein

Neurology Clinic, PC
Cordova, TN United States

John Dougherty

University of Tennessee Medical Center. Knoxville
Knoxville, TN United States

Lora McGill

Clinical Neuroscience Solutions, Inc.
Memphis, TN United States

Benjamin Williams

UT Southwestern Medical Center at Dallas
Dallas, TX United States

Joseph Kass

Baylor College of Medicine
Houston, TX United States

John Scott

National Clinical Research Inc.-Richmond
Richmond, VA United States

Piero Antuono

Medical College of Wisconsin, Inc.
Milwaukee, WI United States

Aducanumab Global Clinical Trial Center

St Vincent's Hospital Sydney
Darlinghurst, Australia

Aducanumab Global Clinical Trial Center

Central Coast Neurosciences Research, Gosford
East Gosford, Australia

Aducanumab Global Clinical Trial Center

KARA Institute for Neurological Diseases
North Ryde, Australia

Aducanumab Global Clinical Trial Center

Calvary Mater Newcastle
Waratah, Australia

Aducanumab Global Clinical Trial Center

Queensland University of Technology
Brisbane, Australia

Aducanumab Global Clinical Trial Center

The Prince Charles Hospital
Chermside, Australia

Aducanumab Global Clinical Trial Center

Royal Brisbane and Women's Hospital
Herston, Australia

Aducanumab Global Clinical Trial Center

Toowoomba Base Hospital
Toowoomba, Australia

Aducanumab Global Clinical Trial Center

Box Hill Hospital
Box Hill, Australia

Aducanumab Global Clinical Trial Center

Austin Hospital
Heidelberg, Australia

Aducanumab Global Clinical Trial Center

Royal Melbourne Hospital
Parkville, Australia

Aducanumab Global Clinical Trial Center

McCusker Alzheimer's Research Foundation
Nedlands, Australia

Aducanumab Global Clinical Trial Center

Neurodegenerative Disorders Research
West Perth, Australia

Aducanumab Global Clinical Trial Center

LKH - Universitaetsklinikum Graz
Graz, Austria

Aducanumab Global Clinical Trial Center

Christian-Doppler-Klinik - Universit tsklinikum Salzburg
Salzburg, Austria

Aducanumab Global Clinical Trial Center

AKH - Medizinische Universit t Wien
Vienna, Austria

Aducanumab Global Clinical Trial Center

Heritage Medical Research Clinic
Calgary, AB Canada

Aducanumab Global Clinical Trial Center

The Medical Arts Health Research Group
Penticton, BC Canada

Aducanumab Global Clinical Trial Center

UBC Hospital
Vancouver, BC Canada

Aducanumab Global Clinical Trial Center

Toronto Memory Program (Neurology Research Inc.)
Toronto, ON Canada

Aducanumab Global Clinical Trial Center

Toronto Sunnybrook Hospital
Toronto, ON Canada

Aducanumab Global Clinical Trial Center

The Montreal Neurological Institute
Montreal, QC Canada

Aducanumab Global Clinical Trial Center

McGill Centre for Studies in Aging
Verdun, QC Canada

Aducanumab Global Clinical Trial Center

CHU de Quebec - H pital de l' Enfant J sus
Quebec, QC Canada

Line M Lindgren

CCBR - Ballerup - DK
Ballerup, Denmark

Annette Justesen

CCBR - Vejle - DK
Vejle, Denmark

Aducanumab Global Clinical Trial Center

CHU Strasbourg - H pital Hautepierre
Strasbourg Cedex, France

Pierre Anthony

Hopital Louis Pasteur Colmar
Strasbourg, France

Sophie Auriacombe

Groupe Hospitalier Pellegrin - H pital Pellegrin
Bordeaux, France

Aducanumab Global Clinical Trial Center

CHU Reims - H pital Maison Blanche
Reims, France

Helene Mollion

Hopital Neurologique Pierre Wertheimer
Bron Cedex, France

Aducanumab Global Clinical Trial Center

Groupe hospitalier Broca - La Rochefoucauld - La Coll giale
Paris, France

Bruno Dubois

Groupe Hospitalier Pitie-Salpetriere
Paris, France

Aducanumab Global Clinical Trial Center

Praxis Dr. Scholz
Boeblingen, Germany

Aducanumab Global Clinical Trial Center

Aerztliche Gemeinschaftspraxis
Ostfildern, Germany

Aducanumab Global Clinical Trial Center

Neuro MVZ Stuttgart
Stuttgart, Germany

Aducanumab Global Clinical Trial Center

Klinikum der Johann Wolfgang Goethe-Universitaet
Frankfurt, Germany

Aducanumab Global Clinical Trial Center

Praxis Dr. med. Bergmann
Neuburg, Germany

Aducanumab Global Clinical Trial Center

Neurologische Gemeinschaftspraxis Kassel
Kassel, Germany

Aducanumab Global Clinical Trial Center

Klinische Forschung Hannover-Mitte GmbH
Hannover, Germany

Aducanumab Global Clinical Trial Center

Universitaetsklinikum Aachen AOeR
Aachen, Germany

Aducanumab Global Clinical Trial Center

Universitaetsklinikum Bonn AoeR
Bonn, Germany

Aducanumab Global Clinical Trial Center

Universitaetsklinikum Koeln
Cologne, Germany

Aducanumab Global Clinical Trial Center

Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin
Berlin, Germany

Aducanumab Global Clinical Trial Center

Azienda Ospedaliero Universitaria Ospedali Riuniti
Torrette di Ancona, Italy

Aducanumab Global Clinical Trial Center

Azienda Ospedaliera Ospedali Riuniti di Bergamo
Bergamo, Italy

Aducanumab Global Clinical Trial Center

Azienda Ospedaliera Spedali Civili di Brescia
Brescia, Italy

Aducanumab Global Clinical Trial Center

Azienda Ospedaliero Universitaria San Martino
Genova, Italy

Aducanumab Global Clinical Trial Center

Ospedale San Raffaele
Milano, Italy

Aducanumab Global Clinical Trial Center

Casa di Cura del Policlinico
Milano, Italy

Aducanumab Global Clinical Trial Center

Azienda Ospedaliera Universitaria "Federico II"
Napoli, Italy

Aducanumab Global Clinical Trial Center

Seconda Universit degli Studi di Napoli
Napoli, Italy

Aducanumab Global Clinical Trial Center

Azienda Ospedaliero Universitaria Pisana
Pisa, Italy

Aducanumab Global Clinical Trial Center

Policlinico Universitario Agostino Gemelli
Roma, Italy

Aducanumab Global Clinical Trial Center

Azienda Ospedaliera Universitaria OO. RR. S. Giovanni di Dio e Ruggi D'Aragona
Salerno, Italy

Aducanumab Global Clinical Trial Center

A.O.U. Senese Policlinico Santa Maria alle Scotte
Siena, Italy

Aducanumab Global Clinical Trial Center

Research Site
Chiba-Shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Inzai-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Aizuwakamatsu-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Asahikawa-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Sapporo-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Atsugi-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Kamakura-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Kawasaki-Shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Yokohama-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Nagaoka-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Iruma-gun, Japan

Aducanumab Global Clinical Trial Center

Research Site
Kasukabe-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Bunkyo-ku, Japan

Aducanumab Global Clinical Trial Center

Research Site
Shinjuku-ku (I), Japan

Aducanumab Global Clinical Trial Center

Research Site
Shinjuku-ku, Japan

Aducanumab Global Clinical Trial Center

Research Site
Ota-ku, Japan

Aducanumab Global Clinical Trial Center

Research Site
Yamagata-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Itabashi-ku, Japan

Aducanumab Global Clinical Trial Center

Research Site
Kiyose-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Kodaira-shi, Japan

Aducanumab Global Clinical Trial Center

Inha University Hospital
Incheon, Korea, Republic of

Aducanumab Global Clinical Trial Center

Seoul National University Bundang Hospital
Seongnam-si, Korea, Republic of

Aducanumab Global Clinical Trial Center

Gachon University Gil Medical Center
Incheon, Korea, Republic of

Aducanumab Global Clinical Trial Center

Asan Medical Center
Seoul, Korea, Republic of

Aducanumab Global Clinical Trial Center

Samsung Medical Center
Seoul, Korea, Republic of

Aducanumab Global Clinical Trial Center

Konkuk University Medical Center
Seoul, Korea, Republic of

Aducanumab Global Clinical Trial Center

Hospital Professor Doutor Fernando Fonseca, E.P.E.
Amadora, Portugal

Aducanumab Global Clinical Trial Center

Hospital de Braga
Braga, Portugal

Aducanumab Global Clinical Trial Center

Centro Hospitalar e Universit rio de Coimbra E.P.E
Coimbra, Portugal

Aducanumab Global Clinical Trial Center

CUF Alvalade
Lisboa, Portugal

Aducanumab Global Clinical Trial Center

Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital de Santa Maria
Lisboa, Portugal

Aducanumab Global Clinical Trial Center

Hospital Beatriz ngelo
Loures, Portugal

Aducanumab Global Clinical Trial Center

Campus Neurologico Senior
Torres Vedras, Portugal

Nadege Van Blercon

Policlinica Guipuzcoa
San Sebastian, Spain

Aducanumab Global Clinical Trial Center

Hospital de Cruces
Barakaldo, Spain

Aducanumab Global Clinical Trial Center

Fundacio ACE
Barcelona, Spain

Aducanumab Global Clinical Trial Center

Hospital Clinic i Provincial de Barcelona
Barcelona, Spain

Aducanumab Global Clinical Trial Center

Hospital de la Santa Creu i Sant Pau
Barcelona, Spain

Aducanumab Global Clinical Trial Center

Clinica Ruber
Madrid, Spain

Aducanumab Global Clinical Trial Center

Hospital Universitario Dr. Peset
Valencia, Spain

Aducanumab Global Clinical Trial Center

Hospital Universitari i Politecnic La Fe
Valencia, Spain

Aducanumab Global Clinical Trial Center

Changhua Christian Hospital
Changhua, Taiwan

Aducanumab Global Clinical Trial Center

Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung, Taiwan

Aducanumab Global Clinical Trial Center

Kaohsiung Chang Gung Memorial Hospital
Kaohsiung, Taiwan

Aducanumab Global Clinical Trial Center

National Cheng Kung University Hospital
Tainan, Taiwan

Aducanumab Global Clinical Trial Center

National Taiwan University Hospital
Taipei, Taiwan

Aducanumab Global Clinical Trial Center

Chang Gung Memorial Hospital, Linkou
Taoyuan County, Taiwan

Aducanumab Global Clinical Trial Center

Southmead Hospital
Bristol, United Kingdom

Aducanumab Global Clinical Trial Center

Re:Cognition Health Ltd
London, United Kingdom

Aducanumab Global Clinical Trial Center

Charing Cross Hospital
London, United Kingdom

Aducanumab Global Clinical Trial Center

The National Hospital for Neurology and Neurosurgery Centre
London, United Kingdom

Aducanumab Global Clinical Trial Center

Salford Royal
Salford, United Kingdom

Ritchie Craig

The University of Edinburgh
Edinburgh, United Kingdom

Aducanumab Global Clinical Trial Center

Manchester Royal Infirmary
Blackburn, United Kingdom

Aducanumab Global Clinical Trial Center

West Middlesex Hospital
Isleworth, United Kingdom

Aducanumab Global Clinical Trial Center

The RICE Centre
Bath, United Kingdom

Aducanumab Global Clinical Trial Center

Glasgow Memory Clinic Ltd
Glasgow, United Kingdom

Aducanumab Global Clinical Trial Center

Stobhill ACH Hospital
Glasgow, United Kingdom

Aducanumab Global Clinical Trial Center

Ninewells Hospital
Dundee, United Kingdom

Andrew Byrne

Newcastle University
Newcastle upon Tyne, United Kingdom

Aducanumab Global Clinical Trial Center

Kingshill Research Centre
Chippenham, United Kingdom

Raymond Turner

Georgetown University Hospital
Washington, WA United States

Aducanumab Global Clinical Trial Center

Azienda Ospedaliero Universitaria Ospedali Riuniti
Torrette Di Ancona, Italy

Aducanumab Global Clinical Trial Center

Research Site
Kurume-shi, Japan

Aducanumab Global Clinical Trial Center

Research Site
Kyoto-shi, Japan

Aducanumab Global Clinical Trial Center

Central Coast Neurosciences Research
Erina, Australia

Denis Crimmins

Central Coast Neurosciences Research
New South Wales, Australia

Dr. Peter Johannsen

Rigshospitalet
København Ø, Denmark

Anna Areovimata

CCBR - lborg - DK
Ålborg, Denmark

Aducanumab Global Clinical Trial Center

Fondazione Istituto G.Giglio di Cefal
Cefalù, Italy