Last updated on October 2017

221AD301 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer's Disease


Brief description of study

The primary objective of the study is to evaluate the efficacy of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the Clinical Dementia Rating-Sum of Boxes (CDR-SB) score as compared with placebo in participants with early AD. Secondary objectives are to assess the effect of monthly doses of aducanumab as compared with placebo on clinical progression as measured by Mini-Mental State Examination (MMSE), AD Assessment Scale-Cognitive Subscale (13 items) [ADAS-Cog 13], and AD Cooperative Study-Activities of Daily Living Inventory (Mild Cognitive Impairment version) [ADCS-ADL-MCI].

Clinical Study Identifier: NCT02477800

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Jiong Shi

St. Joseph's Hospital and Medical Center
Phoenix, AZ United States
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Michael Badruddoja

Center for Neurosciences
Tucson, AZ United States
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Anthony Ciabarra

Neurology Center of North Orange County
Fullerton, CA United States
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Robert Feldman

Senior Clinical Trials, Inc.
Laguna Hills, CA United States
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Aducanumab Global Clinical Trial Center

Torrance Clinical Research Institute, Inc.
Lomita, CA United States
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Sarah Kremen

University of California - Los Angeles
Los Angeles, CA United States
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Adam Boxer

UCSF - Memory and Aging Center
San Francisco, CA United States
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Thomas Shiovitz

California Neuroscience Research Medical Group Inc.
Sherman Oaks, CA United States
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Brock Summers

Southern California Research LLC
Simi Valley, CA United States
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David Russell

Institute for Neurodegenerative Disorders
New Haven, CT United States
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Raymond Turner

Georgetown University Hospital
Washington, D.C., United States
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Mark Brody

Brain Matters Research, Inc.
Delray Beach, FL United States
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Frederick Schaerf

Neuropsychiatric Research Center of Southwest Florida
Fort Myers, FL United States
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Erin Doty

Jacksonville Center for Clinical Research
Jacksonville, FL United States
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Barry Baumel

University of Miami
Miami, FL United States
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Marc Agronin

Miami Jewish Health Systems
Miami, FL United States
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Aducanumab Global Clinical Trial Center

New Horizon Research Center, Inc
Miami, FL United States
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Craig Curtis

Compass Research Main
Orlando, FL United States
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Michael Tuchman

Palm Beach Neurological Center
Palm Beach Gardens, FL United States
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Mary Stedman

Stedman Clinical Trials, LLC
Tampa, FL United States
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Amanda Smith

USF Health Byrd Institute
Tampa, FL United States
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Cynthia Huffman

Meridien Research
Tampa, FL United States
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David Subich

Compass Research Main
The Villages, FL United States
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Walter Martinez

Premiere Research Institute
West Palm Beach, FL United States
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Po-Heng Tsai

Cleveland Clinic Florida - Weston
Weston, FL United States
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Aducanumab Global Clinical Trial Center

MS Center of Atlanta
Atlanta, GA United States
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Concetta Forchetti

Alexian Brothers Neurosciences Institute
Elk Grove Village, IL United States
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Darren Gitelman

Advocate Lutheran General Hospital
Park Ridge, IL United States
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James Stevens

Fort Wayne Neurological Center
Fort Wayne, IN United States
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Martin Farlow

Indiana University School of Medicine
Indianapolis, IN United States
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Jeffrey Burns

University of Kansas Medical Center Research Institute, Inc.
Kansas City, KS United States
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Paul Murphy

Via Christi Research, a division of Via Christi Hospitals Wichita, Inc.
Wichita, KS United States
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Gregory Cooper

Baptist Health Lexington
Lexington, KY United States
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Scott McGinnis

Brigham & Women's Hosp End/Dbt
Boston, MA United States
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Henry Querfurth

Beth Israel Deaconess Medical Center
Boston, MA United States
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Michael McCartney

ActivMed Practices & Research
Methuen, MA United States
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Donald Marks

Donald S. Marks, M.D., P.C.
Plymouth, MA United States
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David Knopman

Mayo Clinic
Rochester, MN United States
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Barbara Snider

Washington University
Saint Louis, MO United States
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Bharat Mocherla

Las Vegas Medical research
Las Vegas, NV United States
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Sanjiv Sharma

Advanced Memory Research Institute of NJ, PC
Toms River, NJ United States
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Earl Zimmerman

Albany Medical College
Albany, NY United States
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Martin Sadowski

New York University Medical Center PRIME
New York, NY United States
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Anton Porsteinsson

University of Rochester
Rochester, NY United States
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Mohammad Bolouri

ANI Neurology, PLLC d/b/a Alzheimer's Memory Center
Charlotte, NC United States
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Michael Bowman

Raleigh Neurology Associates, P.A.
Raleigh, NC United States
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Babak Tousi

Cleveland Clinic
Cleveland, OH United States
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Carl Griffin

Lynn Health Science Institute
Oklahoma City, OK United States
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Marvin Kalafer

The Clinical Trial Center, LLC
Jenkintown, PA United States
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Oscar Lopez

University of Pittsburgh
Pittsburgh, PA United States
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Mario Cornacchione

Northeastern Pennsylvania Memory and Alzheimer's Center
Plains, PA United States
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John Stoukides

Rhode Island Mood & Memory Research Institute
East Providence, RI United States
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Stephen Salloway

Butler Hospital
Providence, RI United States
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David Clark

Medical University of South Carolina (MUSC)
Charleston, SC United States
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Lee Stein

Neurology Clinic, PC
Cordova, TN United States
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John Dougherty

University of Tennessee Medical Center. Knoxville
Knoxville, TN United States
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Lora McGill

Clinical Neuroscience Solutions, Inc.
Memphis, TN United States
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Benjamin Williams

UT Southwestern Medical Center at Dallas
Dallas, TX United States
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Joseph Kass

Baylor College of Medicine
Houston, TX United States
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John Scott

National Clinical Research Inc.-Richmond
Richmond, VA United States
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Piero Antuono

Medical College of Wisconsin, Inc.
Milwaukee, WI United States
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Aducanumab Global Clinical Trial Center

St Vincent's Hospital Sydney
Darlinghurst, Australia
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Aducanumab Global Clinical Trial Center

Central Coast Neurosciences Research, Gosford
East Gosford, Australia
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Aducanumab Global Clinical Trial Center

KARA Institute for Neurological Diseases
North Ryde, Australia
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Aducanumab Global Clinical Trial Center

Calvary Mater Newcastle
Waratah, Australia
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Aducanumab Global Clinical Trial Center

Queensland University of Technology
Brisbane, Australia
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Aducanumab Global Clinical Trial Center

The Prince Charles Hospital
Chermside, Australia
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Aducanumab Global Clinical Trial Center

Royal Brisbane and Women's Hospital
Herston, Australia
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Aducanumab Global Clinical Trial Center

Toowoomba Base Hospital
Toowoomba, Australia
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Aducanumab Global Clinical Trial Center

Box Hill Hospital
Box Hill, Australia
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Aducanumab Global Clinical Trial Center

Austin Hospital
Heidelberg, Australia
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Aducanumab Global Clinical Trial Center

Royal Melbourne Hospital
Parkville, Australia
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Aducanumab Global Clinical Trial Center

Epworth Healthcare
Richmond, Australia
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Aducanumab Global Clinical Trial Center

McCusker Alzheimer's Research Foundation
Nedlands, Australia
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Aducanumab Global Clinical Trial Center

Neurodegenerative Disorders Research
West Perth, Australia
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Aducanumab Global Clinical Trial Center

LKH - Universitaetsklinikum Graz
Graz, Austria
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Aducanumab Global Clinical Trial Center

Christian-Doppler-Klinik - Universit tsklinikum Salzburg
Salzburg, Austria
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Aducanumab Global Clinical Trial Center

AKH - Medizinische Universit t Wien
Vienna, Austria
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Aducanumab Global Clinical Trial Center

Heritage Medical Research Clinic
Calgary, AB Canada
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Aducanumab Global Clinical Trial Center

The Medical Arts Health Research Group
Penticton, BC Canada
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Aducanumab Global Clinical Trial Center

UBC Hospital
Vancouver, BC Canada
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Aducanumab Global Clinical Trial Center

Toronto Memory Program (Neurology Research Inc.)
Toronto, ON Canada
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Aducanumab Global Clinical Trial Center

Toronto Sunnybrook Hospital
Toronto, ON Canada
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Aducanumab Global Clinical Trial Center

The Montreal Neurological Institute
Montreal, QC Canada
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Aducanumab Global Clinical Trial Center

McGill Centre for Studies in Aging
Verdun, QC Canada
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Aducanumab Global Clinical Trial Center

CHU de Quebec - H pital de l' Enfant J sus
Quebec, QC Canada
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Line Markdanner Lindgren

CCBR - Ballerup - DK
Ballerup, Denmark
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Dr. Peter Johannsen

Rigshospitalet
København Ø, Denmark
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Annette Justesen

CCBR - Vejle - DK
Vejle, Denmark
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Anna Areovimata

CCBR - lborg - DK
Ålborg, Denmark
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Aducanumab Global Clinical Trial Center

CHU Strasbourg - H pital Hautepierre
Strasbourg Cedex, France
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Pierre Anthony

Hopital Louis Pasteur Colmar
Strasbourg, France
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Sophie Auriacombe

Groupe Hospitalier Pellegrin - H pital Pellegrin
Bordeaux, France
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Aducanumab Global Clinical Trial Center

CHU Reims - H pital Maison Blanche
Reims, France
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Helene Mollion

Hopital Neurologique Pierre Wertheimer
Bron Cedex, France
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Aducanumab Global Clinical Trial Center

Groupe hospitalier Broca - La Rochefoucauld - La Coll giale
Paris, France
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Bruno Dubois

Groupe Hospitalier Pitie-Salpetriere
Paris, France
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Aducanumab Global Clinical Trial Center

Praxis Dr. Scholz
Boeblingen, Germany
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Aducanumab Global Clinical Trial Center

Aerztliche Gemeinschaftspraxis
Ostfildern, Germany
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Aducanumab Global Clinical Trial Center

Neuro MVZ Stuttgart
Stuttgart, Germany
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Aducanumab Global Clinical Trial Center

Klinikum der Johann Wolfgang Goethe-Universitaet
Frankfurt, Germany
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Aducanumab Global Clinical Trial Center

Praxis Dr. med. Bergmann
Neuburg, Germany
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Aducanumab Global Clinical Trial Center

Neurologische Gemeinschaftspraxis Kassel
Kassel, Germany
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Aducanumab Global Clinical Trial Center

Klinische Forschung Hannover-Mitte GmbH
Hannover, Germany
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Aducanumab Global Clinical Trial Center

Universitaetsklinikum Aachen AOeR
Aachen, Germany
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Aducanumab Global Clinical Trial Center

Universitaetsklinikum Bonn AoeR
Bonn, Germany
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Aducanumab Global Clinical Trial Center

Universitaetsklinikum Koeln
Cologne, Germany
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Aducanumab Global Clinical Trial Center

Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin
Berlin, Germany
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Aducanumab Global Clinical Trial Center

Azienda Ospedaliero Universitaria Ospedali Riuniti
Torrette di Ancona, Italy
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Aducanumab Global Clinical Trial Center

Fondazione Istituto G.Giglio di Cefal
Cefalù, Italy
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Aducanumab Global Clinical Trial Center

Azienda Ospedaliera Ospedali Riuniti di Bergamo
Bergamo, Italy
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Aducanumab Global Clinical Trial Center

Azienda Ospedaliera Spedali Civili di Brescia
Brescia, Italy
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Aducanumab Global Clinical Trial Center

Azienda Ospedaliero Universitaria San Martino
Genova, Italy
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Aducanumab Global Clinical Trial Center

Ospedale San Raffaele
Milano, Italy
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Aducanumab Global Clinical Trial Center

Casa di Cura del Policlinico
Milano, Italy
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Aducanumab Global Clinical Trial Center

Azienda Ospedaliera Universitaria "Federico II"
Napoli, Italy
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Aducanumab Global Clinical Trial Center

Seconda Universit degli Studi di Napoli
Napoli, Italy
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Aducanumab Global Clinical Trial Center

Azienda Ospedaliero Universitaria Pisana
Pisa, Italy
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Aducanumab Global Clinical Trial Center

Policlinico Universitario Agostino Gemelli
Roma, Italy
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Aducanumab Global Clinical Trial Center

Azienda Ospedaliera Universitaria OO. RR. S. Giovanni di Dio e Ruggi D'Aragona
Salerno, Italy
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Aducanumab Global Clinical Trial Center

A.O.U. Senese Policlinico Santa Maria alle Scotte
Siena, Italy
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Aducanumab Global Clinical Trial Center

Research Site
Aizuwakamatsu-shi, Japan
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Aducanumab Global Clinical Trial Center

Research Site
Asahikawa-shi, Japan
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Aducanumab Global Clinical Trial Center

Research Site
Kamakura-shi, Japan
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Aducanumab Global Clinical Trial Center

Research Site
Kawasaki-Shi, Japan
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Aducanumab Global Clinical Trial Center

Research Site
Yokohama-shi, Japan
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Aducanumab Global Clinical Trial Center

Research Site
Kasukabe-shi, Japan
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Aducanumab Global Clinical Trial Center

Research Site
Shinjuku-ku (I), Japan
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Aducanumab Global Clinical Trial Center

Research Site
Yamagata-shi, Japan
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Aducanumab Global Clinical Trial Center

Inha University Hospital
Incheon, Korea, Republic of
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Aducanumab Global Clinical Trial Center

Seoul National University Bundang Hospital
Seongnam-si, Korea, Republic of
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Aducanumab Global Clinical Trial Center

Gachon University Gil Medical Center
Incheon, Korea, Republic of
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Aducanumab Global Clinical Trial Center

Asan Medical Center
Seoul, Korea, Republic of
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Aducanumab Global Clinical Trial Center

Samsung Medical Center
Seoul, Korea, Republic of
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Aducanumab Global Clinical Trial Center

Konkuk University Medical Center
Seoul, Korea, Republic of
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Aducanumab Global Clinical Trial Center

Hospital Professor Doutor Fernando Fonseca, E.P.E.
Amadora, Portugal
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Aducanumab Global Clinical Trial Center

Hospital de Braga
Braga, Portugal
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Aducanumab Global Clinical Trial Center

Centro Hospitalar e Universit rio de Coimbra E.P.E
Coimbra, Portugal
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Aducanumab Global Clinical Trial Center

Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital de Santa Maria
Lisboa, Portugal
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Aducanumab Global Clinical Trial Center

Hospital Beatriz ngelo
Loures, Portugal
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Aducanumab Global Clinical Trial Center

Campus Neurologico Senior
Torres Vedras, Portugal
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Nadege Van Blercon

Policlinica Guipuzcoa
San Sebastian, Spain
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Aducanumab Global Clinical Trial Center

Hospital de Cruces
Barakaldo, Spain
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Aducanumab Global Clinical Trial Center

Hospital Clinic i Provincial de Barcelona
Barcelona, Spain
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Aducanumab Global Clinical Trial Center

Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
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Aducanumab Global Clinical Trial Center

Hospital Universitario Dr. Peset
Valencia, Spain
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Aducanumab Global Clinical Trial Center

Hospital Universitari i Politecnic La Fe
Valencia, Spain
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Aducanumab Global Clinical Trial Center

Changhua Christian Hospital
Changhua, Taiwan
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Aducanumab Global Clinical Trial Center

Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung, Taiwan
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Aducanumab Global Clinical Trial Center

Kaohsiung Chang Gung Memorial Hospital
Kaohsiung, Taiwan
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Aducanumab Global Clinical Trial Center

National Cheng Kung University Hospital
Tainan, Taiwan
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Aducanumab Global Clinical Trial Center

National Taiwan University Hospital
Taipei, Taiwan
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Aducanumab Global Clinical Trial Center

Chang Gung Memorial Hospital, Linkou
Taoyuan County, Taiwan
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Aducanumab Global Clinical Trial Center

Southmead Hospital
Bristol, United Kingdom
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Aducanumab Global Clinical Trial Center

Re:Cognition Health Ltd
London, United Kingdom
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Aducanumab Global Clinical Trial Center

Charing Cross Hospital
London, United Kingdom
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Aducanumab Global Clinical Trial Center

The National Hospital for Neurology and Neurosurgery Centre
London, United Kingdom
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Aducanumab Global Clinical Trial Center

Salford Royal
Salford, United Kingdom
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Ritchie Craig

The University of Edinburgh
Edinburgh, United Kingdom
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Aducanumab Global Clinical Trial Center

Manchester Royal Infirmary
Blackburn, United Kingdom
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Aducanumab Global Clinical Trial Center

West Middlesex Hospital
Isleworth, United Kingdom
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Aducanumab Global Clinical Trial Center

The RICE Centre
Bath, United Kingdom
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Aducanumab Global Clinical Trial Center

Glasgow Memory Clinic Ltd
Glasgow, United Kingdom
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Aducanumab Global Clinical Trial Center

Stobhill ACH Hospital
Glasgow, United Kingdom
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Aducanumab Global Clinical Trial Center

Ninewells Hospital
Dundee, United Kingdom
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Andrew Byrne

Newcastle University
Newcastle upon Tyne, United Kingdom
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Aducanumab Global Clinical Trial Center

Kingshill Research Centre
Chippenham, United Kingdom
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