Last updated on April 2017

Efficacy of ORM-12741 on Agitation/Aggression Symptoms in Alzheimer's Disease


Brief description of study

This study evaluates the effect of ORM-12741 on agitation/aggression symptoms in Alzheimer's disease. Two thirds of the patients will receive ORM-12741 and one third will receive placebo.

Detailed Study Description

ORM-12741 is a potent and selective alpha-2C adrenoceptor (AR)-antagonist. Previous results suggest that the compound may have positive effects on both cognitive and neuropsychiatric symptoms of Alzheimer's Disease. In this study, the effect of ORM-12741 will be evaluated on agitation/aggression symptoms and other neuropsychiatric symptoms. Furthermore, cognition and psychotic and depressive symptoms will be evaluated.

Clinical Study Identifier: NCT02471196

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Juha Rinne, Prof

Clinical Research Services Turku - CRST Oy
Turku, Finland
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