Last updated on August 2017

A Study of Atezolizumab Versus Observation as Adjuvant Therapy in Participants With High-Risk Muscle-Invasive Urothelial Carcinoma After Surgical Resection [IMvigor010]


Brief description of study

This Phase III, open-label, randomized, multicenter study is to evaluate the efficacy and safety of adjuvant treatment with atezolizumab compared with observation in participants with muscle-invasive urothelial carcinoma (UC) who are at high risk for recurrence following resection. Eligible participants will be randomized by a 1:1 ratio into atezolizumab group or control group.

Clinical Study Identifier: NCT02450331

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Mayo Clinic Arizona
Phoenix, AZ United States
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HonorHealth Research Institute - Pima - Virginia G. Piper Cancer Care Network
Scottsdale, AZ United States
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CBCC Global Research Inc., at Comprehensive Blood and Cancer Center
Bakersfield, CA United States
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UCLA
Los Angeles, CA United States
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USC Norris Cancer Center
Los Angeles, CA United States
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Central Coast Medical Oncology
Los Angeles, CA United States
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Torrance Heath Association DBA Torrance Memorial Physican Network / Cancer Care Associate
Redondo Beach, CA United States
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Pacific Central Coast Health Centers SLO Oncology and Hematology
San Luis Obispo, CA United States
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Stanford University Medical Center
Stanford, CA United States
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University Of Colorado
Aurora, CO United States
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The Urology Center of Colorado
Denver, CO United States
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Yale Cancer Center; Medical Oncology
New Haven, CT United States
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University Of Miami Hospital
Miami, FL United States
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Northwestern University Feinberg School Of Medicine
Chicago, IL United States
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University of Chicago; Hematology/Oncology
Chicago, IL United States
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Indiana University
Indianapolis, IN United States
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University of Iowa Hospital & Clinic; Division of Hematology/Oncology
Iowa City, IA United States
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Cancer Center of Kansas
Wichita, KS United States
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Albert B. Chandler Medical Center; University of Kentucky
Lexington, KY United States
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Norton Cancer Institute
Louisville, KY United States
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New England Cancer Specialists
Scarborough, ME United States
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John Hopkins Sidney Kimmel Comprehensive Cancer Center
Baltimore, MD United States
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Chesapeake Urology Research Associates
Towson, MD United States
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Massachusetts General Hospital.
Boston, MA United States
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Dana Farber Cancer Inst.
Boston, MA United States
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Beth Israel Deaconess Medical Center
Boston, MA United States
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University Of Michigan
Ann Arbor, MI United States
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Karmanos Cancer Institute
Detroit, MI United States
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Henry Ford Health System
Detroit, MI United States
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University of Minnesota
Minneapolis, MN United States
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Southeast Nebraska Cancer Ctr
Lincoln, NE United States
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MSK @Basking Ridge
Basking Ridge, NJ United States
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Saint Barnbas Medical Center Cancer Center
Livingston, NJ United States
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MSKCC @ Commack
Commack, NY United States
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MSKCC @ West Harrison
Harrison, NY United States
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Monter Cancer Center
Lake Success, NY United States
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Laura and ISAAC Perlmutter Cancer Center at NYU Langone.
New York, NY United States
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Columbia University Medical Center
New York, NY United States
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Memorial Sloan-Kettering Cancer Center
New York, NY United States
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MSKC @ Rockville
Rockville Centre, NY United States
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MSKCC at Sleepy Hollow
Sleepy Hollow, NY United States
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Associated Medical Professionals of NY, PLLC
Syracuse, NY United States
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Levine Cancer Institute
Charlotte, NC United States
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Duke Cancer Center
Durham, NC United States
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Wake Forest University Baptist Medical Center
Winston-Salem, NC United States
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Fairview Hospital; Cleveland Clinic Cancer Center
Cleveland, OH United States
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Cleveland Clinic
Cleveland, OH United States
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The Ohio State University Wexner Medical Center
Columbus, OH United States
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Hillcrest Hospital; Hirsch Cancer Center
Mayfield Heights, OH United States
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Cleveland CL N Coast Cancer Cr
Sandusky, OH United States
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St. Luke's University Health network
Bethlehem, PA United States
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Penn State Milton S. Hershey Medical Center
Hershey, PA United States
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Abramson Cancer Center; Univ of Pennsylvania
Philadelphia, PA United States
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Kimmel Cancer Center Thomas Jefferson University
Philadelphia, PA United States
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Fox Chase-Temple Cancer Center
Philadelphia, PA United States
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Miriam Hospital
Providence, RI United States
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University of Texas Southwestern
Dallas, TX United States
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Baylor College of Medicine; Gastroenterology
Houston, TX United States
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University of Texas Health Science Center at San Antonio
San Antonio, TX United States
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University of Virginia
Charlottesville, VA United States
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Seattle Cancer Care Alliance
Seattle, WA United States
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Macquarie University Hospital
Macquarie University, Australia
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Royal Brisbane & Women's Hosp; Cancer Care Serv
Herston, Australia
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Monash Medical Centre; Oncology
East Bentleigh, Australia
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Austin and Repatriation Medical Centre; Cancer Services
Melbourne, Australia
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Healthcare Institution "Gomel Regional Clinical Oncologic Dispensary"
Gomel, Belarus
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N.N. Alexandrov National Cancer Centre of Belarus
Minsk District, Belarus
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Minsk City Clinical Oncologic Dispensary
Minsk, Belarus
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Vitebsk Regional Clinical Oncology Dispensary
Vitebsk, Belarus
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ZNA Middelheim
Antwerpen, Belgium
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Institut Jules Bordet
Bruxelles, Belgium
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Cliniques Universitaires St-Luc
Bruxelles, Belgium
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UZ Leuven Gasthuisberg
Leuven, Belgium
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Sint Augustinus Wilrijk
Wilrijk, Belgium
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Cross Cancer Institute ; Dept of Medical Oncology
Edmonton, AB Canada
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BCCA-Vancouver Cancer Centre
Vancouver, BC Canada
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QEII HSC; Oncology
Halifax, NS Canada
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Royal Victoria Hospital
Barrie, ON Canada
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London Regional Cancer Centre
London, ON Canada
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Lakeridge Health Oshawa; Oncology
Oshawa, ON Canada
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The Ottawa Hospital Cancer Centre; Oncology
Ottawa, ON Canada
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North York General Hospital
Toronto, ON Canada
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Sunnybrook Odette Cancer Centre
Toronto, ON Canada
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McGill University; Glen Site; Oncology
Montreal, QC Canada
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Centre Hospitalier universitaire de Qu bec/ Hotel Dieu de Qu bec
Quebec, QC Canada
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Cancer Hospital Chinese Academy of Medical Sciences.
Beijing, China
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Peking University First Hospital
Beijing, China
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Friendship Hospital, Capital Medical University
Beijing, China
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Peking University Third Hospital
Beijing, China
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Beijing Cancer Hospital
Beijing, China
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the First Hospital of Jilin University
Changchun, China
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Hu Nan Provincial Cancer Hospital
Changsha, China
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The Second Affiliated Hospital, Sun Yat-sen University
Guangzhou City, China
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Sun Yet-sen University Cancer Center
Guangzhou, China
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Jiangsu Cancer Hospital
Nanjing, China
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Jiangsu Province Hospital
Nanjing, China
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Huashan Hospital Affiliated to Fudan University
Shanghai City, China
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Fudan University Shanghai Cancer Center
Shanghai, China
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Zhongshan Hospital Fudan University
Shanghai, China
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Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, China
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Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, China
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The 2nd Hospital of Tianjin Medical University
Tianjin, China
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Tianjin Cancer Hospital; urologic tumor
Tianjin, China
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Masarykuv onkologicky ustav
Brno, Czechia
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University Hospital Olomouc
Olomouc, Czechia
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Hospital Pardubice
Pardubice, Czechia
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University Hospital Motol; Department of Urology
Praha 5, Czechia
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Helsinki University Central Hospital; Urology Clinics
Helsinki, Finland
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Tampere University Hospital; Dept Of Urology
Tampere, Finland
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Turku University Central Hospital; Urology clinic
Turku, Finland
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ICO Paul Papin; Oncologie Medicale.
Angers, France
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Institut Sainte Catherine;Recherche Clinique
Avignon, France
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Hopital Saint Andre
Bordeaux, France
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Centre Francois Baclesse; Recherche Clinique
Caen, France
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Centre Jean Perrin
Clermont Ferrand, France
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Centre Leon Berard; Departement Oncologie Medicale
Lyon, France
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Centre D'Oncologie de Gentilly; Oncology
Nancy, France
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Centre Antoine Lacassagne
Nice, France
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Hopital Cochin; Unite Fonctionnelle D Oncologie
Paris, France
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Hopital Saint Louis; Oncologie Medicale
Paris, France
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Institut Mutualiste Montsouris; Oncologie
Paris, France
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Hopital Europeen Georges Pompidou; Service D'Oncologie Medicale
Paris, France
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ICO - Site Ren Gauducheau
Saint Herblain, France
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Institut Claudius Regaud; Departement Oncologie Medicale
Toulouse, France
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Institut Gustave Roussy; Departement Oncologie Medicale
Villejuif, France
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Uniklinik RWTH Aachen; Klinik f r Urologie
Aachen, Germany
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Charit - Universit tsmedizin Berlin; CC 8: Chirurgische Medizin; Klinik f r Urologie
Berlin, Germany
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Augusta Kranken-Anstalt gGmbH
Bochum, Germany
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Universit tsklinikum "Carl Gustav Carus"; Klinik und Poliklinik f r Urologie
Dresden, Germany
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Universit tsklinikum D sseldorf; Urologische Klinik
Düsseldorf, Germany
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Uniklinik Essen; Urologische Klinik & Poliklinik
Essen, Germany
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Asklepios Klinik Altona, Abteilung f r Urologie
Hamburg, Germany
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Universit tsklinikum der Ruhr-Universit t Bochum, Marien-Hospital Herne, Urologische Klinik
Herne, Germany
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Universit tsklinikum des Saarlandes; Klinik f r Urologie und Kinderurologie
Homburg/Saar, Germany
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Medizinische Fakult t Mannheim, Universit tsklinikum Mannheim, Klinik f r Urologie
Mannheim, Germany
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Klinikum rechts der Isar der TU M nchen; Urologische Klinik und Poliklinik
München, Germany
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Universit tsmedizin Rostock, Urologische Klinik und Poliklinik
Rostock, Germany
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Diakonie-Klinikum Stuttgart, Urologische Klinik
Stuttgart, Germany
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Universit tsklinikum T bingen; Klinik f r Urologie
Tübingen, Germany
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Universit tsklinikum Ulm; Klinik f r Urologie
Ulm, Germany
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Alexandras General Hospital of Athens; Oncology Department
Athens, Greece
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University Hospital of Patras Medical Oncology
Patras, Greece
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Ranbam Health Care Campus; Oncology - Hafia
Hafia, Israel
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Shaare Zedek Medical Center; Oncology Dept
Jerusalem, Israel
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Hadassah Ein Karem Hospital; Oncology Dept
Jerusalem, Israel
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Meir Medical Center; Oncology
Kfar-Saba, Israel
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Rabin Medical Center; Oncology Dept
Petach Tikva, Israel
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Chaim Sheba Medical Center; Oncology Dept
Ramat Gan, Israel
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Tel-Aviv Sourasky Medical Center
Tel Aviv, Israel
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Assaf Harofeh; Oncology
Zerifin, Israel
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Az. Osp. Cardarelli; Divisione Di Oncologia
Napoli, Italy
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ISTITUTO NAZIONALE TUMORI IRCCS FONDAZIONE G. PASCALE; Dipartimento Uro-Ginecologico
Napoli, Italy
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Azienda Ospedaliero-Universitaria S.Orsola-Malpighi; Unit Operativa Oncologia Medica
Bologna, Italy
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IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica
Meldola, Italy
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Azienda Ospedaliera San Camillo Forlanini; Oncologia Medica
Roma, Italy
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Irccs Ospedale San Raffaele;Oncologia Medica
Milano, Italy
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Irccs Istituto Europeo Di Oncologia (IEO); Cure Mediche
Milano, Italy
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A.O. UNIVERSITARIA S. LUIGI GONZAGA; Oncologia Medica
Orbassano, Italy
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Azienda USL8 Arezzo-Presidio Ospedaliero 1 San Donato;U.O.C. Oncologia
Arezzo, Italy
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Azienda Ospedaliera S. Maria - Terni; Oncologia
Terni, Italy
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Nagoya University Hospital; Urology
Aichi, Japan
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Hirosaki University School of Medicine & Hospital; Urology
Aomori, Japan
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Hiroshima City Hiroshima Citizens Hospital; Urology
Hiroshima, Japan
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National Hospital Organization Hokkaido Cancer Center
Hokkaido, Japan
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University of Tsukuba Hospital
Ibaraki, Japan
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Iwate Medical University Hospital; Urology
Iwate, Japan
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Kyoto University Hospital
Kyoto, Japan
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Shikoku Cancer Center
Matsuyama-shi, Japan
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Niigata University Medical & Dental Hospital
Niigata, Japan
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Okayama University Hospital
Okayama, Japan
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Osaka University Hospital; Urology
Osaka, Japan
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Kindai University Hospital; Urology
Osaka, Japan
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Saitama Medical University International Medical Center
Saitama, Japan
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Shizuoka Cancer Center; Urology
Shizuoka, Japan
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National Cancer Center Hospital; Urology
Tokyo, Japan
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The University of Tokyo Hospital
Tokyo, Japan
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The Cancer Institute Hospital, JFCR; Urology
Tokyo, Japan
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Tokyo Women's Medical University Hospital
Tokyo, Japan
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Kyorin University Hospital
Tokyo, Japan
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National Cancer Center
Gyeonggi-do, Korea, Republic of
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Severance Hospital, Yonsei University Health System
Seoul, Korea, Republic of
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Asan Medical Center
Seoul, Korea, Republic of
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Samsung Medical Center
Seoul, Korea, Republic of
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VU MEDISCH CENTRUM; Dept. of Medical Oncology
Amsterdam, Netherlands
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Academ Ziekenhuis Groningen; Medical Oncology
Groningen, Netherlands
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UMC Radboud Nijmegen
Nijmegen, Netherlands
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Erasmus Mc - Daniel Den Hoed Kliniek; Interne Oncologie
Rotterdam, Netherlands
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St. Antonius locatie Leidsche Rijn
Utrecht, Netherlands
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KO-MED Centra Kliniczne Lublin II
Lublin, Poland
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Oddzial Chemioterapii Szpitala Klinicznego Nr 1 w Poznaniu
Poznan, Poland
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