Last updated on November 2017

Study of ACP-196 Versus Ibrutinib in Previously Treated Subjects With High Risk Chronic Lymphocytic Leukemia


Brief description of study

Study of ACP-196 Versus Ibrutinib in Previously Treated Subjects With High Risk Chronic Lymphocytic Leukemia

Detailed Study Description

This study is designed to evaluate progression-free survival for ACE-196 vs ibrutinib in previously treated chronic lymphocytic leukemia.

Intervention:
ACP-196 will be orally administered until disease progression or unacceptable toxicity.
Ibrutinib will be orally administered until disease progression or unacceptable toxicity.

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Randomized, Multicenter, Open-Label, Non-Inferiority, Phase 3 Study of ACP-196 Versus Ibrutinib in Previously Treated Subjects With High Risk Chronic Lymphocytic Leukemia

Clinical Study Identifier: TX6903

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Anna Nasinska

Zaklad Opieki Zdrowotnej MSW z Warminsko-Mazurskim Centrum Onkologii
Olsztyn, XX Poland
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Melih Aktan

Istanbul Universitesi Istanbul Tip Fakultesi Hastanesi
Istanbul, XX Turkey
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Judith Hogg

Castle Hill Hospital
Cottingham, XX United Kingdom
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Sarah Pegorer

Cliniques Universitaires UCL de Mont-Godinne
Yvoir, XX Belgium
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Yael Auman

Rabin Medical Center
Petah Tikva, XX Israel
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Caitlin Demont

Illinois Cancer Care
Peoria, IL USA
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Alexis Mark

Long Island Jewish Medical Center
New Hyde Park, NY USA
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Laura Carter

Scott and White Healthcare
Round Rock, TX USA
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Annebet Gerssen-Goedhart

Spaarne Ziekenhuis
Hoofddorp, XX Netherlands
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Serena Schmitz

Hunterdon Regional Cancer Center
Flemington, NJ USA
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David Cotterell

Christie Hospital
Manchester, XX United Kingdom
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Ela Lutwak

Galilee Medical Center
Nahariya, XX Israel
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Fiby George

Icahn School of Medicine at Mount Sinai
New York, NY USA
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Barbara Ercoli

Icahn School of Medicine at Mount Sinai
Rozzano (MI), XX Italy
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Brenda Gilbertz

Medical Oncology Associates
Spokane, WA USA
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Julia Varga

Georgetown University Medical Center
Washington, DC USA
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Sanne Kjær

Aalborg Universitetshospital
Ålborg, XX Denmark
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Heather Duyck

Frontier Cancer Center and Blood Institute
Billings, MT USA
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Dina Oz

Clinical Research Alliance Inc
Lake Success, NY USA
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Margaret Ross

Tauranga Hospital
Tauranga, XX New Zealand
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Corry Leunis

Ikazia Ziekenhuis
Rotterdam, XX Netherlands
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Annie-Claude Nelson

Hopital Avicenne
Bobigny, XX France
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Susan Stockton

Cancer Center of Kansas
Wichita, KS USA
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Nathalie Bozzolla

Hôpital Pontchaillou
Rennes, XX France
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Ana Garay

Hospital Universitario 12 de Octubre
Madrid, XX Spain
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Debi Kadoun

Northwest Medical Specialties
Gig Harbor, WA USA
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Leonora Conneely

Royal Marsden NHS Foundation Trust
Sutton, XX United Kingdom
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Melissa Devos

Regionaal Ziekenhuis Jan Yperman VZW
Ieper, XX Belgium
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Daniela Schellenberg

Erasmus MC
Rotterdam, XX Netherlands
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Bouchra Chafiq

Hopital Henri Mondor
Créteil, XX France
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Katalin Andok

Somogy Megyei Kaposi Mór Oktató Kórház
Kaposvár, XX Hungary
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Melinda Catala

UCLA Hematology/Oncology
Los Angeles, CA USA
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Limor Dan

Rambam Health Corporation
Haifa, XX Israel
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Sarah Ormerod

Southampton University Hospitals NHS Trust
Southampton, XX United Kingdom
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Melanie Jones

Nottingham City Hospital
Nottingham, XX United Kingdom
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Emily Kaplan

Weill Cornell Medical College
New York, NY USA
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Jemma Hurcomb

Canterbury Health Laboratories
Christchurch, XX New Zealand
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Olga Fernandez

Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, XX Spain
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Marta Hernandez

Hospital General Universitario Gregorio Marañon
Madrid, XX Spain
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Eloise Scarano

Ospedale San Raffaele S.r.l.
Milano, XX Italy
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Monica Mansilla Suarez

Instituto Catalan de Oncologia de Hospitalet (ICO)
Barcelona, XX Spain
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Alex Hickman

Barts and The London School of Medicine and Dentistry
London, XX United Kingdom
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Raquel Fernandez Ordoño

Hospital Universitario Infanta Leonor
Madrid, XX Spain
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Ayna Beden

St James University Hospital
Leeds, XX United Kingdom
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Suna Cangurus

Ankara University Medical Faculty Ibni Sina Hospital
Ankara, XX Turkey
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Borbala Szekely

Debreceni Egyetem Klinikai Kozpont
Debrecen, XX Hungary
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Nick Stankovich

Calvary Mater Newcastle
Waratah, XX Australia
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Hannelore Vaneeckhaute

UZ Leuven
Leuven, XX Belgium
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Lyndsey Ferguson

Ohio State University Comprehensive Cancer Center
Columbus, OH USA
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Judy Jensen

CentraCare Health
St. Cloud, MN USA
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Marjolein Spiering

Academisch Medisch Centrum Amsterdam
Amsterdam, XX Netherlands
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Casey Aitken

Mayo Clinic
Rochester, MN USA
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Muruvvet Buyukpapuc

Erciyes University School of Medicine
Kayseri, XX Turkey
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Kirsty Morrison

Leicester Royal Infirmary
Leicester, XX United Kingdom
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Erin Congdon

UC San Diego Moores Cancer Center
La Jolla, CA USA
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Margaret Marriott

Ingalls Memorial Hospital
Harvey, IL USA
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Valerie Simon

Centre Henri Becquerel
Rouen, XX France
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Sylvia Sprangers

Albert Schweitzer Ziekenhuis
Dordrecht, XX Netherlands
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Patricia Plenge

St Vincent's Hospital Sydney
Darlinghurst, XX Australia
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Giulia Debbia

Azienda Ospedaliero Universitaria Di Modena Policlinico
Modena, XX Italy
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Molly Fanning

Abramson Cancer Center of The University of Pennsylvania
Philadelphia, PA USA
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Monica Serrano

Royal Bournemouth Hospital
Bournemouth, XX United Kingdom
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Valentina Zanetti

Azienda Socio-Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Milano, XX Italy
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Helena Corrigüelas Armillas

Hospital de La Santa Creu i Sant Pau
Barcelona, XX Spain
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Linda van Dommelen

Universitair Medisch Centrum Utrecht
Utrecht, XX Netherlands
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Eva Yip

Royal North Shore Hospital
St. Leonards, XX Australia
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Ádám Kretz

Semmelweis Egyetem
Budapest, XX Hungary
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Yemisi Olurebi

Maryland Oncology Hematology PA
Gettysburg, PA USA
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Erna Helmantel

Universitair Medisch Centrum Groningen
Groningen, XX Netherlands
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Charlotte Dekeyzer

UZ Gent
Gent, XX Belgium
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Neil Bailey

Swedish Medical Center
Washington, WA USA
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James Whitehouse

Birmingham Heartlands Hospital
Birmingham, XX United Kingdom
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Tracey Wellman

Royal Liverpool Hospital
Liverpool, XX United Kingdom
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Elyce Turba

H Lee Moffitt Cancer Center and Research Institute
Tampa, FL USA
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Edith van Druten

Reinier de Graaf Gasthuis
Delft, XX Netherlands
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Daria Kulakova

Lady Davis Carmel Medical Center
Haifa, XX Israel
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Catherine Martin

Wollongong Hospital
Wollongong, XX Australia
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Pia Fagelman

Cambridge University Hospitals NHS Foundation Trust
Cambridge, XX United Kingdom
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Anna Krawczynska

Wojewodzki Szpital Specjalistyczny im. M. Kopernika w Lodzi
Lódz, XX Poland
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Krisztina Kovacs

Országos Onkológiai Intézet
Budapest, XX Hungary
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Liat Tourjeman

Shaare Zedek Medical Center
Jerusalem, XX Israel
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Julien Lepore

Centre Hospitalier Lyon Sud
Pierre Benite, XX France
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Sanny Sloof

Gelre Ziekenhuizen
Apeldoorn, XX Netherlands
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Kristen Houdyk

Peter Maccallum Cancer Centre
East Melbourne, XX Australia
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Meghan Bharadwaj

City of Hope National Medical Center
Duarte, CA USA
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Jelle Meinema

Tergooiziekenhuizen
Hilversum, XX Netherlands
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Leocadia Gonzalez Perez

North Shore Hospital
Takapuna, XX New Zealand
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Marisa Valentinetti

Hackensack University Medical Center
Hackensack, NJ USA
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Marianne van Nistelrooy

Gelre Ziekenhuizen
Zutphen, XX Netherlands
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Inge Paas

Wilhelmina Ziekenhuis Assen
Assen, XX Netherlands
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Dana Weizer

Bnei Zion Medical Center
Haifa, XX Israel
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Peggy Sorenson

MC Haaglanden
Den Haag, XX Netherlands
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Judith Westra

OLVG locatie Oost
Amsterdam, XX Netherlands
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Sandra Silvis

Maxima Medisch Centrum
Veldhoven, XX Netherlands
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Annelies Sneppe

AZ Sint-Jan AV
Brugge, XX Belgium
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Leotine Seip-van den Tillaart

Zuyderland Medisch Centrum
Sittard, XX Netherlands
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Julie East

Frankston Hospital
Frankston, XX Australia
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Laura Sellers

Genesis Cancer Center
Santander, XX Spain
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Laura Sellers

Genesis Cancer Center
Santander, XX Spain
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Odelia Katz

Baruch Padeh Poriya Medical Center
Tiberias, XX Israel
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Amandine Virlojeux

Institut Universitaire du Cancer de Toulouse - Oncopole
Toulouse, XX France
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Charlene D. Perl

Mayo Clinic Jacksonville
Jacksonville, FL USA
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Ozge Gunduz Gokalp

Dokuz Eylul University Medical Faculty
Izmir, XX Turkey
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Denise Soldati

Fondazione Policlinico Universitario A Gemelli
Rome, XX Italy
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Hedwig Stuivenberg

Leids Universitair Medisch Centrum
Leiden, XX Netherlands
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Grazyna Czucha-Deyk

Szpital Morski im PCK
Gdynia, XX Poland
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Joanna Karczewska

Zaklad Opieki Zdrowotnej MSW z Warminsko-Mazurskim Centrum Onkologii
Gdansk, XX Poland
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Magdalena Pierzchalska

Zaklad Opieki Zdrowotnej MSW z Warminsko-Mazurskim Centrum Onkologii
Slupsk, XX Poland
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Elyce Turba

Zaklad Opieki Zdrowotnej MSW z Warminsko-Mazurskim Centrum Onkologii
Tampa, FL USA
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James Dennis

Zaklad Opieki Zdrowotnej MSW z Warminsko-Mazurskim Centrum Onkologii
Cincinnati, OH USA
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Tuan Lê

Cliniques Universitaires Saint-Luc
Bruxelles, XX Belgium
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Julie Mort

University Hospital of Wales
Cardiff, XX United Kingdom
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Milena Czyz

Szpital Uniwersytecki Nr 2 im. Dr Jana Biziela w Bydgoszczy
Bydgoszcz, XX Poland
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Ece Yapar

Ege Universitesi Tip Fakultesi Hastanesi
Izmir, XX Turkey
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Agata Guarrera

Azienda Ospedaliera Universitaria Careggi
Firenze, XX Italy
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Hanna Weissbrot

Columbia University Medical Center
New York, NY USA
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Federica Zumaglini

Ospedale Santa Maria Delle Croci
Ravenna, XX Italy
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Ann Purdom

Texas Tech University HSC University Medical Center
Lubbock, TX USA
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Margreet Stroomer

Slotervaartziekenhuis
Amsterdam, XX Netherlands
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Lone Lytthans Holst

Sjællands Universitetshospital, Roskilde
Roskilde, XX Denmark
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Kim Underwood

University of Virginia
Charlottesville, VA USA
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Rebecca Jones

University of California Irvine
Irvine, CA USA
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Christiane Raymundo

Alta Bates Summit Medical Center
Berkeley, CA USA
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Lieneke Homans

Ziekenhuis Gelderse Vallei
Ede, XX Netherlands
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Michaela Mantz

Universitätsklinikum Ulm
Ulm, XX Germany
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Lonneke Drubbel

Flevoziekenhuis
Almere, XX Netherlands
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Sue Mayost

Chaim Sheba Medical Center
Ramat Gan, XX Israel
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Elsie Anderson

Park Nicollet Institute
St. Louis Park, MN USA
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Christy Strayhorn

Duke University Medical Center
Durham, NC USA
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Sarah Renner

MD Anderson Cancer Center
Houston, TX USA
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Birgit von Poblocki

Hämatologische und Internistische Gemeinschaftspraxis Dr. Eckart, Dr. Häcker
Erlangen, XX Germany
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Natasha Chana

Kings College Hospital
London, XX United Kingdom
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Annette Schuh

Churchill Hospital
Oxford, XX United Kingdom
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Malgorzata Gerjatowicz-Osmanska

Malopolskie Centrum Medyczne
Kraków, XX Poland
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Hulya Kurku

Koc University Medical Faculty American Hospital
Istanbul, XX Turkey
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Seda Vural

Gazi University Medical Faculty Gazi Hospital
Ankara, XX Turkey
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Elena Saccenti

Azienda Ospedaliero-Universitaria di Ferrara - Arcispedale Sant' Anna
Cona, XX Italy
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Francesca Fabbri

Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori IRST
Forli-Cesena, XX Italy
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Garrett Miller

Ohio State University Comprehensive Cancer Center
Columbus, OH USA
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