Last updated on November 2017

Study of ACP-196 Versus Ibrutinib in Previously Treated Subjects With High Risk Chronic Lymphocytic Leukemia


Brief description of study

Study of ACP-196 Versus Ibrutinib in Previously Treated Subjects With High Risk Chronic Lymphocytic Leukemia

Detailed Study Description

This study is designed to evaluate progression-free survival for ACE-196 vs ibrutinib in previously treated chronic lymphocytic leukemia.

Intervention:
ACP-196 will be orally administered until disease progression or unacceptable toxicity.
Ibrutinib will be orally administered until disease progression or unacceptable toxicity.

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Randomized, Multicenter, Open-Label, Non-Inferiority, Phase 3 Study of ACP-196 Versus Ibrutinib in Previously Treated Subjects With High Risk Chronic Lymphocytic Leukemia

Clinical Study Identifier: TX6903

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Anna Nasinska

Zaklad Opieki Zdrowotnej MSW z Warminsko-Mazurskim Centrum Onkologii
Olsztyn, XX Poland

Melih Aktan

Istanbul Universitesi Istanbul Tip Fakultesi Hastanesi
Istanbul, XX Turkey

Judith Hogg

Castle Hill Hospital
Cottingham, XX United Kingdom

Sarah Pegorer

Cliniques Universitaires UCL de Mont-Godinne
Yvoir, XX Belgium

Yael Auman

Rabin Medical Center
Petah Tikva, XX Israel

Caitlin Demont

Illinois Cancer Care
Peoria, IL USA

Alexis Mark

Long Island Jewish Medical Center
New Hyde Park, NY USA

Laura Carter

Scott and White Healthcare
Round Rock, TX USA

Annebet Gerssen-Goedhart

Spaarne Ziekenhuis
Hoofddorp, XX Netherlands

Serena Schmitz

Hunterdon Regional Cancer Center
Flemington, NJ USA

David Cotterell

Christie Hospital
Manchester, XX United Kingdom

Ela Lutwak

Galilee Medical Center
Nahariya, XX Israel

Fiby George

Icahn School of Medicine at Mount Sinai
New York, NY USA

Barbara Ercoli

Icahn School of Medicine at Mount Sinai
Rozzano (MI), XX Italy

Brenda Gilbertz

Medical Oncology Associates
Spokane, WA USA

Julia Varga

Georgetown University Medical Center
Washington, DC USA

Sanne Kjær

Aalborg Universitetshospital
Ålborg, XX Denmark

Heather Duyck

Frontier Cancer Center and Blood Institute
Billings, MT USA

Dina Oz

Clinical Research Alliance Inc
Lake Success, NY USA

Margaret Ross

Tauranga Hospital
Tauranga, XX New Zealand

Corry Leunis

Ikazia Ziekenhuis
Rotterdam, XX Netherlands

Annie-Claude Nelson

Hopital Avicenne
Bobigny, XX France

Susan Stockton

Cancer Center of Kansas
Wichita, KS USA

Nathalie Bozzolla

Hôpital Pontchaillou
Rennes, XX France

Ana Garay

Hospital Universitario 12 de Octubre
Madrid, XX Spain

Debi Kadoun

Northwest Medical Specialties
Gig Harbor, WA USA

Leonora Conneely

Royal Marsden NHS Foundation Trust
Sutton, XX United Kingdom

Melissa Devos

Regionaal Ziekenhuis Jan Yperman VZW
Ieper, XX Belgium

Daniela Schellenberg

Erasmus MC
Rotterdam, XX Netherlands

Bouchra Chafiq

Hopital Henri Mondor
Créteil, XX France

Katalin Andok

Somogy Megyei Kaposi Mór Oktató Kórház
Kaposvár, XX Hungary

Melinda Catala

UCLA Hematology/Oncology
Los Angeles, CA USA

Limor Dan

Rambam Health Corporation
Haifa, XX Israel

Sarah Ormerod

Southampton University Hospitals NHS Trust
Southampton, XX United Kingdom

Melanie Jones

Nottingham City Hospital
Nottingham, XX United Kingdom

Emily Kaplan

Weill Cornell Medical College
New York, NY USA

Jemma Hurcomb

Canterbury Health Laboratories
Christchurch, XX New Zealand

Olga Fernandez

Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, XX Spain

Marta Hernandez

Hospital General Universitario Gregorio Marañon
Madrid, XX Spain

Eloise Scarano

Ospedale San Raffaele S.r.l.
Milano, XX Italy

Monica Mansilla Suarez

Instituto Catalan de Oncologia de Hospitalet (ICO)
Barcelona, XX Spain

Alex Hickman

Barts and The London School of Medicine and Dentistry
London, XX United Kingdom

Raquel Fernandez Ordoño

Hospital Universitario Infanta Leonor
Madrid, XX Spain

Ayna Beden

St James University Hospital
Leeds, XX United Kingdom

Suna Cangurus

Ankara University Medical Faculty Ibni Sina Hospital
Ankara, XX Turkey

Borbala Szekely

Debreceni Egyetem Klinikai Kozpont
Debrecen, XX Hungary

Nick Stankovich

Calvary Mater Newcastle
Waratah, XX Australia

Hannelore Vaneeckhaute

UZ Leuven
Leuven, XX Belgium

Lyndsey Ferguson

Ohio State University Comprehensive Cancer Center
Columbus, OH USA

Judy Jensen

CentraCare Health
St. Cloud, MN USA

Marjolein Spiering

Academisch Medisch Centrum Amsterdam
Amsterdam, XX Netherlands

Casey Aitken

Mayo Clinic
Rochester, MN USA

Muruvvet Buyukpapuc

Erciyes University School of Medicine
Kayseri, XX Turkey

Kirsty Morrison

Leicester Royal Infirmary
Leicester, XX United Kingdom

Erin Congdon

UC San Diego Moores Cancer Center
La Jolla, CA USA

Margaret Marriott

Ingalls Memorial Hospital
Harvey, IL USA

Valerie Simon

Centre Henri Becquerel
Rouen, XX France

Sylvia Sprangers

Albert Schweitzer Ziekenhuis
Dordrecht, XX Netherlands

Patricia Plenge

St Vincent's Hospital Sydney
Darlinghurst, XX Australia

Giulia Debbia

Azienda Ospedaliero Universitaria Di Modena Policlinico
Modena, XX Italy

Molly Fanning

Abramson Cancer Center of The University of Pennsylvania
Philadelphia, PA USA

Monica Serrano

Royal Bournemouth Hospital
Bournemouth, XX United Kingdom

Valentina Zanetti

Azienda Socio-Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Milano, XX Italy

Helena Corrigüelas Armillas

Hospital de La Santa Creu i Sant Pau
Barcelona, XX Spain

Linda van Dommelen

Universitair Medisch Centrum Utrecht
Utrecht, XX Netherlands

Eva Yip

Royal North Shore Hospital
St. Leonards, XX Australia

Ádám Kretz

Semmelweis Egyetem
Budapest, XX Hungary

Yemisi Olurebi

Maryland Oncology Hematology PA
Gettysburg, PA USA

Erna Helmantel

Universitair Medisch Centrum Groningen
Groningen, XX Netherlands

Charlotte Dekeyzer

UZ Gent
Gent, XX Belgium

Neil Bailey

Swedish Medical Center
Washington, WA USA

James Whitehouse

Birmingham Heartlands Hospital
Birmingham, XX United Kingdom

Tracey Wellman

Royal Liverpool Hospital
Liverpool, XX United Kingdom

Elyce Turba

H Lee Moffitt Cancer Center and Research Institute
Tampa, FL USA

Edith van Druten

Reinier de Graaf Gasthuis
Delft, XX Netherlands

Daria Kulakova

Lady Davis Carmel Medical Center
Haifa, XX Israel

Catherine Martin

Wollongong Hospital
Wollongong, XX Australia

Pia Fagelman

Cambridge University Hospitals NHS Foundation Trust
Cambridge, XX United Kingdom

Anna Krawczynska

Wojewodzki Szpital Specjalistyczny im. M. Kopernika w Lodzi
Lódz, XX Poland

Krisztina Kovacs

Országos Onkológiai Intézet
Budapest, XX Hungary

Liat Tourjeman

Shaare Zedek Medical Center
Jerusalem, XX Israel

Julien Lepore

Centre Hospitalier Lyon Sud
Pierre Benite, XX France

Sanny Sloof

Gelre Ziekenhuizen
Apeldoorn, XX Netherlands

Kristen Houdyk

Peter Maccallum Cancer Centre
East Melbourne, XX Australia

Meghan Bharadwaj

City of Hope National Medical Center
Duarte, CA USA

Jelle Meinema

Tergooiziekenhuizen
Hilversum, XX Netherlands

Leocadia Gonzalez Perez

North Shore Hospital
Takapuna, XX New Zealand

Marisa Valentinetti

Hackensack University Medical Center
Hackensack, NJ USA

Marianne van Nistelrooy

Gelre Ziekenhuizen
Zutphen, XX Netherlands

Inge Paas

Wilhelmina Ziekenhuis Assen
Assen, XX Netherlands

Dana Weizer

Bnei Zion Medical Center
Haifa, XX Israel

Peggy Sorenson

MC Haaglanden
Den Haag, XX Netherlands

Judith Westra

OLVG locatie Oost
Amsterdam, XX Netherlands

Sandra Silvis

Maxima Medisch Centrum
Veldhoven, XX Netherlands

Annelies Sneppe

AZ Sint-Jan AV
Brugge, XX Belgium

Leotine Seip-van den Tillaart

Zuyderland Medisch Centrum
Sittard, XX Netherlands

Julie East

Frankston Hospital
Frankston, XX Australia

Laura Sellers

Genesis Cancer Center
Santander, XX Spain

Laura Sellers

Genesis Cancer Center
Santander, XX Spain

Odelia Katz

Baruch Padeh Poriya Medical Center
Tiberias, XX Israel

Amandine Virlojeux

Institut Universitaire du Cancer de Toulouse - Oncopole
Toulouse, XX France

Charlene D. Perl

Mayo Clinic Jacksonville
Jacksonville, FL USA

Ozge Gunduz Gokalp

Dokuz Eylul University Medical Faculty
Izmir, XX Turkey

Denise Soldati

Fondazione Policlinico Universitario A Gemelli
Rome, XX Italy

Hedwig Stuivenberg

Leids Universitair Medisch Centrum
Leiden, XX Netherlands

Grazyna Czucha-Deyk

Szpital Morski im PCK
Gdynia, XX Poland

Joanna Karczewska

Zaklad Opieki Zdrowotnej MSW z Warminsko-Mazurskim Centrum Onkologii
Gdansk, XX Poland

Magdalena Pierzchalska

Zaklad Opieki Zdrowotnej MSW z Warminsko-Mazurskim Centrum Onkologii
Slupsk, XX Poland

Elyce Turba

Zaklad Opieki Zdrowotnej MSW z Warminsko-Mazurskim Centrum Onkologii
Tampa, FL USA

James Dennis

Zaklad Opieki Zdrowotnej MSW z Warminsko-Mazurskim Centrum Onkologii
Cincinnati, OH USA

Tuan Lê

Cliniques Universitaires Saint-Luc
Bruxelles, XX Belgium

Julie Mort

University Hospital of Wales
Cardiff, XX United Kingdom

Milena Czyz

Szpital Uniwersytecki Nr 2 im. Dr Jana Biziela w Bydgoszczy
Bydgoszcz, XX Poland

Ece Yapar

Ege Universitesi Tip Fakultesi Hastanesi
Izmir, XX Turkey

Agata Guarrera

Azienda Ospedaliera Universitaria Careggi
Firenze, XX Italy

Hanna Weissbrot

Columbia University Medical Center
New York, NY USA

Federica Zumaglini

Ospedale Santa Maria Delle Croci
Ravenna, XX Italy

Ann Purdom

Texas Tech University HSC University Medical Center
Lubbock, TX USA

Margreet Stroomer

Slotervaartziekenhuis
Amsterdam, XX Netherlands

Lone Lytthans Holst

Sjællands Universitetshospital, Roskilde
Roskilde, XX Denmark

Kim Underwood

University of Virginia
Charlottesville, VA USA

Rebecca Jones

University of California Irvine
Irvine, CA USA

Christiane Raymundo

Alta Bates Summit Medical Center
Berkeley, CA USA

Lieneke Homans

Ziekenhuis Gelderse Vallei
Ede, XX Netherlands

Michaela Mantz

Universitätsklinikum Ulm
Ulm, XX Germany

Lonneke Drubbel

Flevoziekenhuis
Almere, XX Netherlands

Sue Mayost

Chaim Sheba Medical Center
Ramat Gan, XX Israel

Elsie Anderson

Park Nicollet Institute
St. Louis Park, MN USA

Christy Strayhorn

Duke University Medical Center
Durham, NC USA

Sarah Renner

MD Anderson Cancer Center
Houston, TX USA

Birgit von Poblocki

Hämatologische und Internistische Gemeinschaftspraxis Dr. Eckart, Dr. Häcker
Erlangen, XX Germany

Natasha Chana

Kings College Hospital
London, XX United Kingdom

Annette Schuh

Churchill Hospital
Oxford, XX United Kingdom

Malgorzata Gerjatowicz-Osmanska

Malopolskie Centrum Medyczne
Kraków, XX Poland

Hulya Kurku

Koc University Medical Faculty American Hospital
Istanbul, XX Turkey

Seda Vural

Gazi University Medical Faculty Gazi Hospital
Ankara, XX Turkey

Elena Saccenti

Azienda Ospedaliero-Universitaria di Ferrara - Arcispedale Sant' Anna
Cona, XX Italy

Francesca Fabbri

Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori IRST
Forli-Cesena, XX Italy

Garrett Miller

Ohio State University Comprehensive Cancer Center
Columbus, OH USA