Last updated on August 2018

A Study of Biomarker-Driven Therapy in Metastatic Colorectal Cancer (mCRC)


Brief description of study

This randomized, multi-center, active-controlled, open-label, parallel-group study will investigate the efficacy and safety of biomarker-driven maintenance treatment for first-line mCRC. Participants with mCRC are eligible for entry and cannot have received any prior chemotherapy in the metastatic setting. The entire study duration is anticipated to be approximately 7.5 years.

Clinical Study Identifier: NCT02291289

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Reference Study ID Number: MO29112 ...

Centre Anti Cancer Beau-fraisier;Service d'oncologie m dicale
Algiers, Algeria

Reference Study ID Number: MO29112 ...

CHU Oran; Service d'Oncologie M dicale
Oran, Algeria

Reference Study ID Number: MO29112 ...

EHS Oncologie Emir Abdelkader Oran; Service d'Oncologie M dicale
Oran, Algeria

Reference Study ID Number: MO29112 ...

CHU de Tizi Ouzou; Service d'Oncologie M dicale
Tizi Ouzou, Algeria

Reference Study ID Number: MO29112 ...

Hospital de Gastroenterologia Dr. Bonorino Udaondo ; Servicio de Oncolog a
Buenos Aires, Argentina

Reference Study ID Number: MO29112 ...

Centro Oncologico Riojano Integral (CORI)
La Rioja, Argentina

Reference Study ID Number: MO29112 ...

Cl nica Viedma
Viedma, Rio Negro, Argentina

Reference Study ID Number: MO29112 ...

Institut Jules Bordet X
Brussels, Belgium

Reference Study ID Number: MO29112 ...

UZ Leuven Gasthuisberg
Leuven, Belgium

Reference Study ID Number: MO29112 ...

AZ Delta (Campus Wilgenstraat)
Roeselare, Belgium

Reference Study ID Number: MO29112 ...

University Clinical Center of the Republic of Srpska
Banja Luka, Bosnia and Herzegovina

Reference Study ID Number: MO29112 ...

Clinic of Oncology, University Clinical Center Sarajevo
Sarajevo, Bosnia and Herzegovina

Reference Study ID Number: MO29112 ...

Clinicas Oncologicas Integradas - COI
Rio De Janeiro, Brazil

Reference Study ID Number: MO29112 ...

CITO - Centro Integrado de Terapia Onco-Hematol gica - Hospital da Cidade de Passo Fundo
Passo Fundo, Brazil

Reference Study ID Number: MO29112 ...

Hospital das Clinicas - UFRGS
Porto Alegre, Brazil

Reference Study ID Number: MO29112 ...

Hospital Sao Lucas - PUCRS
Porto Alegre, Brazil

Reference Study ID Number: MO29112 ...

Hospital Nossa Senhora da Conceicao
Porto Alegre, Brazil

Reference Study ID Number: MO29112 ...

Hospital de Cancer de Barretos
Barretos, Brazil

Reference Study ID Number: MO29112 ...

Hospital Amaral Carvalho
Jau, Brazil

Reference Study ID Number: MO29112 ...

Hospital de Base de Sao Jose do Rio Preto
Sao Jose do Rio Preto, Brazil

Reference Study ID Number: MO29112 ...

Instituto de Ensino e Pesquisa Sao Lucas - IEP
Sao Paulo, Brazil

Reference Study ID Number: MO29112 ...

Instituto do Cancer do Estado de Sao Paulo - ICESP
Sao Paulo, Brazil

Reference Study ID Number: MO29112 ...

Bank of Cyprus Oncology Center
Nicosia, Cyprus

Reference Study ID Number: MO29112 ...

Herlev Hospital; Onkologisk afdeling
Herlev, Denmark

Reference Study ID Number: MO29112 ...

Regionshospitalet Herning; Onkologisk afdeling
Herning, Denmark

Reference Study ID Number: MO29112 ...

Hiller d Sygehus; Medicinsk Enhed 1, 0862
Hillerod, Denmark

Reference Study ID Number: MO29112 ...

Odense Universitetshospital, Onkologisk Afdeling R
Odense, Denmark

Reference Study ID Number: MO29112 ...

Sygehus Syd Roskilde; Onkologisk/haematologisk ambulatorium
Roskilde, Denmark

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Cancer Epidemiology Research Cluster; Clinical Cancer Department
Alexandria, Egypt

Reference Study ID Number: MO29112 ...

National Cancer Institute
Cairo, Egypt

Reference Study ID Number: MO29112 ...

Ain Shams University Hospital; Oncology
Cairo, Egypt

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Clinique Sainte Catherine
Avignon, France

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HOPITAL JEAN MINJOZ; Oncologie
Besancon, France

Reference Study ID Number: MO29112 ...

Hopital Augustin Morvan; Federation De Cancerologie
Brest, France

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Chu Estaing; Chir Generale Digestive A Et B
Clermont Ferrand, France

Reference Study ID Number: MO29112 ...

Institut Hospitalier Franco-Britannique; Cancerologie
Levallois-Perret, France

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Hopital Claude Huriez; Medecine Interne Oncologie
Lille, France

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Ch De Montbeliard;Chir Generale Digestive
Montbeliard, France

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Hopital Caremeau; Gastro Enterologie
Nimes, France

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Hopital Saint Antoine; Oncologie Medicale
Paris, France

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Hopital Haut Leveque
Pessac, France

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Chu La Miletrie; Gastro Enterologie Endoscopies
Poitiers, France

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Centre Paul Strauss; Oncologie Medicale
Strasbourg, France

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Hopital Rangueil; Gastro Enterologie Et Nutrition
Toulouse, France

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Institut Gustave Roussy; Departement Oncologie Medicale
Villejuif, France

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H matologisch-onkologische Praxis Dr. med. - Brudler, - Heinrich, - Bangerter
Augsburg, Germany

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Charit -Universit tsm. Berlin; Med. Klinik mit Schwerpunkt H matologie, Onkologie und Tumorimmunolo.
Berlin, Germany

Reference Study ID Number: MO29112 ...

Onkologische Schwerpunktpraxis Kurf rstendamm
Berlin, Germany

Reference Study ID Number: MO29112 ...

DRK Kliniken Berlin K penick Darmzentrum
Berlin, Germany

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Krankenhaus Nordwest; Klinik f. Onkologie und H matologie
Frankfurt, Germany

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PIOH PD Dr. R. Schnell - Dr. H. Schulz - Dr. M. Hellmann
Frechen, Germany

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Klinik Fulda, Medizinisches Versorgungszentrum Osthessen GmbH
Fulda, Germany

Reference Study ID Number: MO29112 ...

Universit tsklinikum Hamburg-Eppendorf, Onkologisches Zentrum, Studienzentrale der II. Med. Klinik
Hamburg, Germany

Reference Study ID Number: MO29112 ...

Medizinische Hochschule; Zentrum Innere Medizin; Abt. H matologie u. Onkologie
Hannover, Germany

Reference Study ID Number: MO29112 ...

SLK-Kliniken Heilbronn GmbH Klinik f r Innere Medizin III, Onkologisches Studienzentrum
Heilbronn, Germany

Reference Study ID Number: MO29112 ...

Klinik der Ruhr-Uni Bochum; Marien-Hospital Herne
Herne, Germany

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Gemeinschaftspraxis; Onkologisches Zentrum Lebach; Caritas Krankenhaus Lebach
Lebach, Germany

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Onkologische Gemeinschaftspraxis
Magdeburg, Germany

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Klinikum Magdeburg gGmbH Klinik f r Allgemein- und Viszeralchirurgie
Magdeburg, Germany

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Br derkrankenhaus St. Josef
Paderborn, Germany

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Studienzentrum Onkologie Ravensburg; Onkologie Ravensburg
Ravensburg, Germany

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Prosper-Hospital, Medizinische Klinik I
Recklinghausen, Germany

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Krankenhaus Barmherziger Br der; Klinik f r Internistische Onkologie / H matologie
Regensburg, Germany

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Klinikum am Steinenberg / Ermstalklinik
Reutlingen, Germany

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Praxis F r Haematologie & Onkologie
Saarbruecken, Germany

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MVZ f r H matologie, Onkologie, Strahlentherapie und Palliativmedizin -; Klinik Dr. Hancken
Stade, Germany

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Klinikum Mutterhaus der Borromaeerinnen gGmbH; Haematologie/Onkologie
Trier, Germany

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Klinikum Wetzlar-Braunfels, Klinik f r H matologie/Onkologie und Palliativmedizin
Wetzlar, Germany

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Agioi Anargyroi; 3Rd Dept. of Medical Oncology
Athens, Greece

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Univ General Hosp Heraklion; Medical Oncology
Heraklion, Greece

Reference Study ID Number: MO29112 ...

Uni Hospital of Ioannina; Oncology Dept.
Ioannina, Greece

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University Hospital of Patras Medical Oncology
Patras, Greece

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Thermi Clinic; Oncology Clinic
Thermi Thessalonikis, Greece

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Bioclinic Thessaloniki
Thessaloniki, Greece

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IRCCS Istituto Nazionale Tumori Fondazione Pascale; Oncologia Medica A
Napoli, Italy

Reference Study ID Number: MO29112 ...

IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica
Meldola, Italy

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A.O. Universitaria Di Parma; Oncologia Medica
Parma, Italy

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Istituto Regina Elena; Oncologia Medica A
Roma, Italy

Reference Study ID Number: MO29112 ...

Policlinico Universitario "Agostino Gemelli"; U.O.C. Oncologia Medica
Roma, Italy

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Humanitas Gavazzeni;U.O. Oncologia Medica
Bergamo, Italy

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Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 1
Milano, Italy

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Irccs Istituto Europeo Di Oncologia (IEO); Oncologia Medica
Milano, Italy

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Asst Grande Ospedale Metropolitano Niguarda; Dipartimento Di Ematologia Ed Oncologia
Milano, Italy

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A.O. Citt della Salute e della Scienza - Presidio Molinette; divisione oncologia medica
Torino, Italy

Reference Study ID Number: MO29112 ...

IRCCS Ospedale Casa Sollievo Della Sofferenza; Oncologia
San Giovanni Rotondo, Italy

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Azienda Ospedaliero-Universitaria Careggi;S.C. Oncologia Medica 1
Firenze, Italy

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IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Prima
Padova, Italy

Reference Study ID Number: MO29112 ...

A.O.U.I. VERONA-OSPEDALE POLICLINICO G.B. ROSSI BORGO ROMA;ONCOLOGIA MEDICA-d.U.
Verona, Italy

Reference Study ID Number: MO29112 ...

Seoul National University Hospital
Seoul, Korea, Republic of

Reference Study ID Number: MO29112 ...

Severance Hospital, Yonsei University Health System
Seoul, Korea, Republic of

Reference Study ID Number: MO29112 ...

Asan Medical Center
Seoul, Korea, Republic of

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Samsung Medical Center
Seoul, Korea, Republic of

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Instituto Nacional de Cancerologia; Oncology
Distrito Federal, Mexico

Reference Study ID Number: MO29112 ...

Oaxaca Site Management Organization
Oaxaca, Mexico

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Cancerologia de Queretaro; Oncologia
Queretaro, Queretaro, Mexico

Reference Study ID Number: MO29112 ...

Antoni van Leeuwenhoek Ziekenhuis
Amsterdam, Netherlands

Reference Study ID Number: MO29112 ...

Academisch Medisch Centrum Universiteit Amsterdam
Amsterdam, Netherlands

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Ijsselland Ziekenhuis; Inwendige Geneeskunde
Capelle a/d IJssel, Netherlands

Reference Study ID Number: MO29112 ...

Deventer Ziekenhuis; Interne Geneeskunde
Deventer, Netherlands

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Albert Schweitzer Ziekenhuis; Inwendige Geneeskunde
Dordrecht, Netherlands

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Catharina ZKHS; Inwendige Geneeskunde Afd.
Eindhoven, Netherlands

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UMC St Radboud; Interne Oncologie; Medical Oncology Department
Nijmegen, Netherlands

Reference Study ID Number: MO29112 ...

St. Antonius locatie Leidsche Rijn
Utrecht, Netherlands

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Isala Klinieken
Zwolle, Netherlands

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Szpital Uniwersytecki w Krakowie, Oddzia Kliniczny Kliniki Onkologii
Krakow, Poland

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Centrum Onkologii - Instytut im. M. Sklodowskiej-Curie; Klinika Gastroenterologii Onkologicznej
Warszawa, Poland

Reference Study ID Number: MO29112 ...

HUC; Servico de Oncologia Medica
Coimbra, Portugal

Reference Study ID Number: MO29112 ...

Centro Clinico Champalimaud; Oncologia Medica
Lisboa, Portugal

Reference Study ID Number: MO29112 ...

Hospital de Santa Maria; Servico de Oncologia Medica
Lisboa, Portugal

Reference Study ID Number: MO29112 ...

Russian Oncology Research Center n.a. N.N. Blokhin Dpt of Clinical Pharmacology and Chemotherapy
Moscow, Russian Federation

Reference Study ID Number: MO29112 ...

P.A. Herzen Oncological Inst. ; Oncology
Moscow, Russian Federation

Reference Study ID Number: MO29112 ...

First Pavlov State Medical University of St.Petersburg
Saint-Petersburg, Russian Federation

Reference Study ID Number: MO29112 ...

S-Pb clinical scientific practical center of specialized kinds of medical care (oncological)
Saint-Petersburg, Russian Federation

Reference Study ID Number: MO29112 ...

Bashkirian Republican Clinical Oncology Dispensary
UFA, Russian Federation

Reference Study ID Number: MO29112 ...

Institute for Oncology and Radiology of Serbia; Medical Oncology
Belgrade, Serbia

Reference Study ID Number: MO29112 ...

Clinical Center Bezanijska Kosa
Belgrade, Serbia

Reference Study ID Number: MO29112 ...

Oncology Institute of Vojvodina
Sremska Kamenica, Serbia

Reference Study ID Number: MO29112 ...

Onkologicky ustav sv. Alzbety, s.r.o.
Bratislava, Slovakia

Reference Study ID Number: MO29112 ...

Narodny Onkologicky Ustav; Oddelenie klinickej onkologie E
Bratislava, Slovakia

Reference Study ID Number: MO29112 ...

POKO Poprad; Department of Oncology
Poprad, Slovakia

Reference Study ID Number: MO29112 ...

Institute of Oncology Ljubljana
Ljubljana, Slovenia

Reference Study ID Number: MO29112 ...

Hospital General Universitario de Elche; Servicio de Oncologia
Elche, Spain

Reference Study ID Number: MO29112 ...

Hospital Univ. Central de Asturias; Servicio de Oncologia
Oviedo, Spain

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Hospital Universitario Marques de Valdecilla; Servicio de Oncologia
Santander, Spain

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Hospital de Donostia; Servicio de Oncologia Medica
San Sebastian, Spain

Reference Study ID Number: MO29112 ...

Hospital Universitario Son Espases
Palma De Mallorca, Spain

Reference Study ID Number: MO29112 ...

Complejo Hospitalario Universitario de Santiago (CHUS) ; Servicio de Oncologia
Santiago de Compostela, Spain

Reference Study ID Number: MO29112 ...

Complejo Hospitalario Nuestra Se ora de la Candelaria; Servicio de Oncologia
Santa Cruz de Tenerife, Spain

Reference Study ID Number: MO29112 ...

Hospital General Univ. de Alicante; Servicio de Oncologia
Alicante, Spain

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Hospital Univ Vall d'Hebron; Servicio de Oncologia
Barcelona, Spain

Reference Study ID Number: MO29112 ...

Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia
Jaen, Spain

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Hospital Universitari Arnau de Vilanova de Lleida; Servicio de Oncologia
Lerida, Spain

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Hospital General Universitario Gregorio Mara on; Servicio de Oncologia
Madrid, Spain

Reference Study ID Number: MO29112 ...

Hospital Ramon y Cajal; Servicio de Oncologia
Madrid, Spain

Reference Study ID Number: MO29112 ...

Hospital Universitario 12 de Octubre; Servicio de Oncologia
Madrid, Spain

Reference Study ID Number: MO29112 ...

Hospital Universitario La Paz; Servicio de Oncologia
Madrid, Spain

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Hospital Universitario Puerta de Hierro; Servicio de Oncologia
Madrid, Spain

Reference Study ID Number: MO29112 ...

Hospital Regional Universitario Carlos Haya; Servicio de Oncologia
Malaga, Spain

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Hospital de Navarra; Servicio de Oncologia
Navarra, Spain

Reference Study ID Number: MO29112 ...

Complejo Hospitalario de Orense; Servicio de Oncologia
Orense, Spain

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Hospital General Universitario de Valencia; Servicio de oncologia
Valencia, Spain

Reference Study ID Number: MO29112 ...

Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia
Valencia, Spain

Reference Study ID Number: MO29112 ...

Hospital Universitario la Fe; Servicio de Oncologia
Valencia, Spain

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Hospital Clinico Universitario Lozano Blesa; Servicio de Oncologia
Zaragoza, Spain

Reference Study ID Number: MO29112 ...

Hospital Universitario Miguel Servet; Servicio Oncologia
Zaragoza, Spain

Reference Study ID Number: MO29112 ...

Sk nes University Hospital, Sk nes Department of Onclology
Lund, Sweden

Reference Study ID Number: MO29112 ...

Karolinska Hospital; Oncology - Radiumhemmet
Stockholm, Sweden

Reference Study ID Number: MO29112 ...

Acibadem University School of Medicine, Adana Hospital; General Surgery
Adana, Turkey

Reference Study ID Number: MO29112 ...

Trakya University Medical Faculty Research And Practice Hospital Medical Oncology Department
Edirne, Turkey

Reference Study ID Number: MO29112 ...

Istanbul Uni Capa Medical Faculty; Inst. of Oncology
Istanbul, Turkey

Reference Study ID Number: MO29112 ...

Marmara Uni Faculty of Medicine; Medical Oncology
Istanbul, Turkey

Reference Study ID Number: MO29112 ...

Ege Uni Medical Faculty Hospital; Oncology Dept
Izmir, Turkey

Reference Study ID Number: MO29112 ...

Euromedical General Clinic of Thessaloniki; Oncology Department
Thessaloniki, Greece

Reference Study ID Number: MO29112 ...

Ijsselland Ziekenhuis; Inwendige Geneeskunde
Capelle A/d IJssel, Netherlands

Reference Study ID Number: MO29112 ...

Hospital Erasme; Neurologie
Bruxelles, Belgium

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BAG Freiberg-Richter, Jacobasch, Illmer, Wolf; Gemeinschaftspraxis H matologie-Onkologie
Dresden, Germany

Reference Study ID Number: MO29112 ...

Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia
Badalona, Spain

Reference Study ID Number: MO29112 ...

Hospital de Cruces; Servicio de Oncologia
Bilbao, Spain

Reference Study ID Number: MO29112 ...

Universit tsklinikum Magdeburg Klinik f r Gastroenterologie und Hepatologie
Magdeburg, Germany

Reference Study ID Number: MO29112 ...

Clinique Saint-Joseph
Liège, Belgium

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Rigshospitalet, Onkologisk Klinik
København Ø, Denmark

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Kliniken Maria Hilf GmbH, Krankenhaus St. Franziskus
Mönchengladbach, Germany

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St dt. Klinikum M nchen GmbH Klinikum Neuperlach Klinik f.H matologie u.Onkologie
München, Germany

Reference Study ID Number: MO29112 ...

Gemeinschaftspraxis f r H matologie und Onkologie
Münster, Germany

Reference Study ID Number: MO29112 ...

Universit tsklinikum W rzburg; Medizinische Klinik und Poliklinik II; H matologie / Onkologie
Würzburg, Germany

Reference Study ID Number: MO29112 ...

Fundacion Rodolfo Padilla Padilla A.C.
León, Mexico

Reference Study ID Number: MO29112 ...

Hospital Universitario Reina Sofia; Servicio de Oncologia
Córdoba, Spain

Reference Study ID Number: MO29112 ...

Uni Hospital Linkoeping; Dept. of Oncology
Linköping, Sweden