Last updated on September 2018

Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomerulosclerosis in Children


Brief description of study

Liposorber LA-15 System is a blood purification therapy that selectively removes malignant lipoproteins including low density lipoprotein from circulating blood flow and rapidly reduces the plasma cholesterol level. The system was originally developed for the treatment of patients with serious dyslipidemia such as familial hypercholesterolemia and then applied to improve the dyslipidemia, a common complication of nephrotic syndrome and found to bring about improvement not only with the dyslipidemic condition but the nephrotic condition (e.g, proteinuria and hypoproteinemia).

Although the definitive mechanism by which the system may relieve nephrotic syndrome is unknown, it has been recognized as one of alternative therapies for refractory nephrotic syndrome including focal segmental glomerulosclerosis (FSGS) in Japan and referred in the Guidelines for the Treatment of Nephrotic Syndrome endorsed by The Japanese Society of Nephrology.

This study is conducted as a post approval study imposed by Humanitarian Device Exemption (HDE) order to confirm the safety and efficacy of the Liposorber LA-15 System in the treatment of drug-resistant pediatric primary FSGS.

Clinical Study Identifier: NCT02235857

Contact Investigators or Research Sites near you

Start Over

Joshua Zaritsky, MD PhD

Nemours/A.I. duPont Hospital for Children
Wilmington, DE United States
  Connect »

Laleh Abedinzadeh, MD

Nemours Children's Hospital, Orlando
Orlando, FL United States
  Connect »

Rupesh Raina, MD

Akron Children's Hospital
Akron, OH United States
  Connect »

Cheryl P Sanchez-Kazi, MD

Loma Linda University Children's Hospital
Loma Linda, CA United States
  Connect »

Alejandro Quiroga, MD

Helen DeVos Children's Hospital
Grand Rapids, MI United States
  Connect »

Katherine E Twombley, MD

Medical University of South Carolina Children's Hospital
Charleston, SC United States
  Connect »

Megan M Lo, MD

Children's Hospital of Richmond at VCU
Richmond, VA United States
  Connect »