Last updated on April 2009

Efficacy Study of Atorvastatin to Treat Variant Angina

Brief description of study

The objective of this study is to evaluate effect of statin treatment for vasospastic angina.

Detailed Study Description

Vasospastic angina is presented by myocardial ischemia with spasm of coronary artery accompanying chest pain or discomfort. The precise mechanisms have not been established, but a reduction in NO (nitric oxide) production, an imbalance between endothelium-derived relaxing and contracting factors,or an injury of endothelium have been suggested. Impaired FMD(flow mediated endothelium-dependent vasodilation) in the brachial artery was demonstrated in vasospastic angina,and improvement of endothelial dysfunction with treatment of statin is documented in several studies. So, we expect that statin treatment for vasospastic angina provide additional therapeutic effects via improvement of endothelial dysfunction.

Clinical Study Identifier: NCT00620204

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Hyun-chul Gwon, MD,PhD

Samsung Medical Center
Seoul, Korea, Republic of
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