Last updated on July 2017

Stroke in Young Fabry Patients (sifap2): Characterization of the Stroke Rehabilitation


Brief description of study

New studies indicate that in about 1 - 2 percent of the younger stroke patients the cause could have been an undiagnosed genetic disease, the so called Fabry disease. In this case certain fat molecules are not digested and broken down by the body - but remain in the cells. These fat molecules build up to dangerous levels, which start to damage the body, because they accumulate e.g. in the walls of the blood vessels. This accumulation in the blood vessels of the whole body may cause life-threatening malfunctions in the brain, inducing a stroke. The purpose of this study is to investigate the stroke rehabilitation of Fabry patients during different therapeutic standard approaches for stroke and for Fabry disease (if any). During this study, stroke patients with Fabry disease will be monitored in greater detail to determine whether the differences in treatment are significant for patient recovery and on what they depend.

Detailed Study Description

In a group of young stroke patients with diagnosed Fabry disease the stroke rehabilitation will be investigated during different prophylactic therapeutic approaches. In this study the investigator will not be given any instructions on stroke and Fabry therapy. All patients with any etiology of stroke and a diagnosed Fabry disease submitted to the stroke unit of the participating centres which commit to work with the EUSI (European Stroke Initiative) recommendations for stroke management and diagnosis will be included into the study.

Clinical Study Identifier: NCT00413595

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Franz Fazekas, Prof., MD

Universit tsklinikum f r Neurologie
Graz, Austria
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Vida Demarin, Prof. MD

Department of Neurology, University Hospital Sestre Milosrdnice
Zagreb, Croatia
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Laurent Derex, MD

Hopital Neurologique de Lyon, Service d'urgences Neurovasculaires
Lyon, France
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Marina Janelidze, Prof. MD

Department of Neurology, S. Khechinashvili University clinic of Tbilisi state medical university
Tblisi, Georgia
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Patrick Oschmann, Prof., MD

Department of Neurology, Klinikum Hohe Warte
Bayreuth, Germany
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Gerhard J. Jungehülsing, MD

Charite Campus Benjamin Franklin, Dept. of Neurology
Berlin, Germany
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Wolfgang Heide, Prof. MD

Department of Neurology, Allgemeines Krankenhaus Celle
Celle, Germany
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Juergen Klingelhoefer, Prof. MD

Department of Neurology, Klinikum Chemnitz gGmbH
Chemnitz, Germany
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Heinz Reichmann, Prof. MD

Department of Neurology, Universitaetsklinikum Carl Gustav Carus
Dresden, Germany
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Sebastian Jander, Prof., MD

Heinrich-Heine-University Duesseldorf, Dept. of Neurology
Duesseldorf, Germany
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Manfred Kaps, Prof., MD

University of Giessen-Marburg Dept. of Neurology
Giessen, Germany
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Michael Rosenkranz, MD

Department of Neurology, Universitaetsklinikum Hamburg-Eppendorf
Hamburg, Germany
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Otto Witte, Prof. MD

Department of Neurology, Universitaetsklinikum Jena
Jena, Germany
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Dietmar Schneider, Prof. MD

Department of Neurology, Universitaetsklinikum Leipzig
Leipzig, Germany
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Marek Jauß, PD MD

Dept. of Neurology, kumenisches Hainich Klinikum gGmbH
Mühlhausen / Thürigen, Germany
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Martin Dichgans, Prof., MD

Ludwig-Maximilians-University of Munich, Klinikum M nchen-Gro hadern, Dept. of Neurology
München, Germany
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Arthur Melms, Prof., MD

Department of Neurology, University Tuebingen
Tuebingen, Germany
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Albert Ludolph, Prof., MD

University of Ulm, Department of Neurology
Ulm, Germany
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Anna Czlonkowska, Prof. MD

Institute of Psychiatry and Neurology, Dept. of Neurology
Warsaw, Poland
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Joacquim Machado Candido, MD

Centro Hospitalar de Lisboa Central, Servico de Neurologia
Lisboa, Portugal
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