Last updated on June 2006

Standard Palliative Care Versus Standard Palliative Care Plus Polychemotherapy in Metastasized Malignant Melanoma


Brief description of study

The purpose of this multicenter study is to examine whether the proposed randomized treatment regime results in a significantly longer survival time and higher quality of life than any additionally applied multiple chemotherapy according to the CVD- scheme. So far neither established treatment regimes nor reliable data exist for the second-line chemotherapy of metastatic malignant melanoma. Patients are therefore mostly treated with single or multiple chemotherapeutics or/and immunomodulatory therapeutics. These regimes however imply often not only a higher toxicity but show rarely a response rate higher than 10%.

Clinical Study Identifier: NCT00226473

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Dirk Schadendorf, MD

Skin Cancer Unit, German Cancer Ressearch Center and Dept. of Dermatology, University Hospital of Mannheim
Mannheim, Germany
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Claus Garbe, MD

Dept. of Dermatology, University Hospital Tuebingen
Tuebingen, Germany
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Konstanze Spieth, MD

Dept. of Dermatology, University of Frankfurt
Frankfurt, Germany
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Peter Mohr, MD

Dept. of Dermatology, Medical Center Buxtehude
Buxtehude, Germany
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Michael Tronnier, MD

Dept. of Dermatology, Hildesheim
Hildesheim, Germany
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Wolfgang Tilgen, MD

Dept. of. Dermatology, University of Saarland, Homburg
Homburg, Germany
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Jens Ulrich, MD

Dept. of Dermatology, University Otto von Guericke
Magdeburg, Germany
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Axel Hauschild, MD

Dept. of Dermatology, University of Schleswig-Holstein
Kiel, Germany
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Sven Krengel, MD

Dept. of Dermatology, University of Schleswig-Holstein, Campus L beck
Lübeck, Germany
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Ruthild Linse, MD

Dept. of Dermatology, Helios Clinic Erfurt
Erfurt, Germany
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Martin Kaatz, MD

Dept. of Dermatology, University of Jena
Jena, Germany
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Uwe Trefzer, MD

Dept. of Dermatology, Charit Berlin
Berlin, Germany
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Peter Kohl, MD

Dept. of Dermatology, Vivantes Clinics
Berlin, Germany
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