Last updated on June 2006

Standard High-Dose Alpha Interferon Versus Intermittent High-Dose Alpha Interferon

Brief description of study

The study protocol is being conducted to compare intermittent high-dose i.v. administation of interferon alpha-2b with the standard high-dose treatment by Kirkwood with distant metastasis free survival (DMFI) as a primary endpoint.

Detailed Study Description

Arm A: Interferon-alpha-2b 20 MIU/m2 for 4 weeks. 5 days a week i.v followed by 48 weeks of treatment with 3 x 10 MIU/m2 s.c Arm B: Interferon-alpha-2b 20 MIU/m2 for 4 weeks. 5 days a week i.v repeated 3 times with 12 treatment-free-weeks between the cycles Secondary endpoints: Improved overall survival rate, Assess side effects of therapy in both treatment arms, Assess time spent on sick leave, Assess number of treatment-related days in hospital, Assess overall performance status, Assess blood MX protein levels

Clinical Study Identifier: NCT00226408

Contact Investigators or Research Sites near you

Start Over

Norbert Brockmeyer, MD

Universit tshautklinik ,St.Josef- Hospital
Bochum, Germany
  Connect »

Peter Miohr, MD

Elbekliniken Buxtehude
Buxtehude, Germany
  Connect »

Carmen Loquai, MD

Universit tshautklinik Essen
Essen, Germany
  Connect »

Karsten Neuber, MD

Universit tsklinik Eppendorf
Hamburg, Germany
  Connect »

Peter von Wussow, MD

Hannover, Germany
  Connect »

Alexander Enk, MD

Universit tshautklinik Heidelberg
Heidelberg, Germany
  Connect »

Wolfgang Tilgen, MD

Universit tsklinikum des Saarlandes, Hautklinik
Homburg/ Saar, Germany
  Connect »

Axel Hauschild, MD

Christian- Albrechts- Universit t ,Hautklinik
Kiel, Germany
  Connect »

Cornelia Mauch, MD

Universit tshautklinik K ln
Köln, Germany
  Connect »

Kerstin Steinbrink, MD

Universit tshautklinik Mainz
Mainz, Germany
  Connect »

T. Luger, MD

universit tsklinikum M nster
Münster, Germany
  Connect »

Erhard Hölzle, MD

St dtische Kliniken Oldenburg
Oldenburg, Germany
  Connect »

Cord Sunderkötter, MD

Universit tshautklinik Ulm
Ulm, Germany
  Connect »