Last updated on November 2017

A Phase 3 Study (PHOCUS) to determine whether the oncolytic virus immunotherapy called Pexa-Vec (JX-594) can slow the progression of advanced liver cancer (hepatocellular carcinoma or HCC).


Brief description of study

A Phase 3 Study (PHOCUS) to determine whether the oncolytic virus immunotherapy called Pexa-Vec (JX-594) can slow the progression of advanced liver cancer (hepatocellular carcinoma or HCC).

Detailed Study Description

This research study is for people with advanced liver cancer who have never received systemic medicine (affecting the entire body) for advanced liver cancer. This is a randomized, open-label Phase 3 study to determine whether treatment with vaccinia virus based immunotherapy (Pexa-Vec) followed by sorafenib can slow the progression of advanced liver cancer and improve quality of life compared to treatment with sorafenib alone.

Clinical Study Identifier: TX2577

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Irvine, CA USA

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Hamilton, XX Canada

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Clayton, XX Australia

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Fitzroy, XX Australia

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Parkville, Australia

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Footscray, XX Australia

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Singapore, XX Singapore

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Ramat-Gan, XX Israel

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Parma, XX Italy

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Chicago, IL USA

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Billings, MT USA

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Baltimore, MD USA

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Knoxville, TN USA

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St. Louis, MO USA

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Paterson, NJ USA

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Taipei, XX Taiwan

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Auckland, XX New Zealand

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Seattle, WA USA

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Tainan City, XX Taiwan

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Kaoshiung, XX Taiwan

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Taichung, XX Taiwan

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Khon Kaen, XX Thailand

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Kansas City, KS USA

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Adalaide, XX Australia

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Perth, XX Australia

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Haifa, XX Israel

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Palermo, XX Italy

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Modena, XX Italy

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Porto, XX Portugal

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Lisbon, XX Portugal

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Philadelphia, PA USA

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Vandoeuvre-lès-nancy, XX France

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Créteil, XX France

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Tübingen, XX Germany

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München, XX Germany

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Hamburg, XX Germany

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Gainesville, FL USA

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Stanford, CA USA

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Chiang Mai, XX Thailand

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Bangkok, XX Thailand

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Linkou, XX Taiwan

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Bucheon, XX South Korea

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Seoul, XX South Korea

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Brisbane, XX Australia

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Phitsanulok, XX Thailand

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Hat Yai, XX Thailand

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Concord, XX Australia

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Paris, XX France

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Rennes, XX France

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Lille, XX France

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Aachen, XX Germany

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Hannover, XX Germany

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New Orleans, LA USA

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Jerusalem, XX Israel

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Tel-Aviv, XX Israel

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Afula, XX Israel

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Bondy, XX France

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Mainz, XX Germany

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Guildford, XX UK

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Heidelberg, XX Australia

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Strasbourg, XX France

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Dresden, XX Germany

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Frankfurt am Main, XX Germany

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Leeds, XX UK

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Busan, XX South Korea

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Adelaide, XX Australia

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Camperdown, XX Australia

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Birmingham, AL USA

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Seongnam-si, XX South Korea

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Coimbra, XX Portugal

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Nice, XX France

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Christchurch, XX New Zealand

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Louisville, KY USA

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Jinju-si, XX South Korea

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Toulouse, XX France

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Ansan, XX South Korea

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Columbus, OH USA

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Daegu, XX South Korea

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Dallas, TX USA

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Minneapolis, MN USA

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Scottsdale, AZ USA

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Suwon, XX South Korea