Last updated on September 2018

China Cognition and Aging Study


Brief description of study

The Cognition and Aging Study (COAST) was designed to establish a prospective cohort to clarify the clinical and genetic characteristics, pathogenesis, diagnosis, treatment of MCI, AD, and VCI in China to establish a national database, to develop a strategy for prevention of dementia. The overarching goals of the COAST are as follow:

  1. To construct a prospective cohort, then to establish database that provide not only comprehensive epidemiological data on the AD and dementia of Chinese elders, but also biological samples and laboratory and image data.
  2. To determine the conversion rates from MCI to dementia or AD and risk factors for the progression from MCI to dementia or AD.
  3. To identify and validate imaging and blood/CSF biomarkers for the early detection and tracking of AD.
  4. To uncover novel risk genes for complex AD and identify the genes related pathogenesis of the disease.

Detailed Study Description

This study involved participants including amnestic mild cognitive impairment (aMCI), sporadic Alzheimer's disease (SAD), familial Alzheimer's disease (FAD), Vascular cognitive impairment (VCI), and APOE gene cohort (cognitive normal subjects). Research contents are as

follow
  1. Neuropsychological characteristics of Chinese aMCI, SAD, VCI: analyze the cognitive function, daily living ability and mental behavior symptoms using MMSE, MoCA, etc. during the baseline and follow-up period.
  2. Neuroimaging of Chinese aMCI, SAD, and VCI: explore the neuroimaging characteristics and disease evolution characteristics through the apocalyptic atrophy, cortical thickness of structure MRI, and standardized uptake values of functional imaging FDG-PET.
  3. Prevention of Chinese aMCI, SAD, and VCI: find the risk factors and environmental factors which were possible related to development of these disease, and propose a preventional strategy for dementia in China.
  4. Pathogenesis of Chinese aMCI, SAD, and VCI: test the investigator's findings (risk factors, genetic factors, environmental factors) in this cohort on animal models.

Clinical Study Identifier: NCT03653156

Contact Investigators or Research Sites near you

Start Over

Yanghua Tian, Doctor

The First Affiliated Hospital of Anhui Medical University
Hefei, China
  Connect »

Jihui Lv

Beijing Geriatric Hospital
Changping, China
  Connect »

Yue Wang, Doctor

Beijing Chao Yang Hospital
Chaoyang, China
  Connect »

Dantao Peng

China-Japan Friendship Hospital
Chaoyang, China
  Connect »

Lanxiang Jin, Doctor

Dongfang Hospital Affiliated to Beijing University of Chinese Medicine
Fengtai, China
  Connect »

Jianjun Jia, Doctor

Chinese PLA General Hospital
Haidian, China
  Connect »

Fang Li, Doctor

Fu Xing Hospital, Capital Medical University
Haidian, China
  Connect »

Weizhong Xiao

Peking University Third Hospital
Haidian, China
  Connect »

Jing Gao, Doctor

Peking Union Medical College Hospital
Xicheng, China
  Connect »

Zhirong Jia

Peking University First Hospital
Xicheng, China
  Connect »

Yanjiang Wang

Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Yuzhong, China
  Connect »

Yangmei Chen

The Second Affiliated Hospital of Chongqing Medical University
Yuzhong, China
  Connect »

Qinyong Ye

Fujian Medical University Union Hospital
Fujian, China
  Connect »

Mouni Tang, Doctor

Guangzhou Psychiatric Hospital
Guangzhou, China
  Connect »

Jun Liu, Doctor

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Zhongshan, China
  Connect »

Shengliang Liang

First Affiliated Hospital of Guangxi Medical University
Nanning, China
  Connect »

Lan Chu, Doctor

The Affiliated Hospital Of Guizhou Medical University
Guiyang, China
  Connect »

Minchen Kan, Doctor

Handan Central Hospital
Handan, China
  Connect »

Huiying Zhao

First Hospital of Shijiazhuang City
Shijiazhuang, China
  Connect »

Yongqiu Li, Doctor

Tangshan Worker's Hospital
Tangshan, China
  Connect »

Peiyuan Lv, Doctor

Hebei General Hospital
Zhijiazhuang, China
  Connect »

Shurong Duan, Doctor

First Affiliated Hospital of Harbin Medical University
Haerbin, China
  Connect »

Huanrong Yu, Doctor

Kaifeng Central Hospital
Kaifeng, China
  Connect »

Jiewen Zhang, Doctor

Henan Provincial People's Hospital
Zhengzhou, China
  Connect »

Shuling Zhang, Doctor

People's Hospital of Zhengzhou
Zhengzhou, China
  Connect »

Jianjun Zhang, Doctor

People's Hospital Affiliated Hubei Medical University
Wuhan, China
  Connect »

Min Zhang

Tongji Hospital
Wuhan, China
  Connect »

Lu Shen

The Third Xiangya Hospital of Central South University
Wuhan, China
  Connect »

Hanxing Liu

Wuhan University Zhongnan Hospital
Wuhan, China
  Connect »

Qiuyun Tu, Doctor

Xiangya Hospital of Central South University
Wuhan, China
  Connect »

Maohong Cao, Doctor

Nantong University Affiliated Hospital
Nantong, China
  Connect »

Jun Xu, Doctor

Subei People's Hospital of Jiangsu
Subei, China
  Connect »

Liangqun Rong, Doctor

Mineral General Hospital, Xuzhou
Xuzhou, China
  Connect »

Kunnan Zhang, Doctor

Jiangxi Provincial People's Hospital
Nanchang, China
  Connect »

Qin Zhao, Doctor

China-Japan friendship Hospital of Jilin university
Changchun, China
  Connect »

Li Sun, Doctor

The First Hospital of Jilin University
Changchun, China
  Connect »

Xiu Han, Doctor

Changda Hospital, Anshan
Anshan, China
  Connect »

Qiang Ma, Doctor

Affiliated Zhongshan hospital of Dalian university
Dalian, China
  Connect »

Cui Wang, Doctor

The First Affiliated Hospital of Dalian Medical University
Dalian, China
  Connect »

Yunpeng Cao, Doctor

First Hospital of China Medical University
Shenyang, China
  Connect »

Furu Liang, Doctor

Baotou Central Hospital
Baotou, China
  Connect »

Qin Zhang, Doctor

General Hospital of Ningxia Medical University
Yinchuan, China
  Connect »

Yongying Gao, Doctor

The People's Hospital of Ningxia
Yinchuan, China
  Connect »

Peiyan Shan, Doctor

Qilu Hospital of Shandong University
Jinan, China
  Connect »

Yifeng Du, Doctor

Shandong Provincial Hospital
Jining, China
  Connect »

Bin Liang, Doctor

Qilu Hospital of Shandong University (Qingdao)
Qingdao, China
  Connect »

Lan Tan, Doctor

QingDao Municipal Hospital
Qingdao, China
  Connect »

Jinping Sun, Doctor

The Affiliated Hospital of Qingdao University
Qingdao, China
  Connect »

Jintao Zhang, Doctor

The 88th Hospital of PLA
Tai'an, China
  Connect »

Jianhua Zhuang, Doctor

Shanghai Changzheng Hospital
Huangpu, China
  Connect »

Gang Wang, Doctor

Ruijin Hospital
Luwan, China
  Connect »

Qun Xu, Doctor

RenJi Hospital
Putong, China
  Connect »

Yuling Tian, Doctor

The First Affiliated Hospital of Shanxi Medical University
Taiyuan, China
  Connect »

Qiumin Qu, Doctor

First Affiliated Hospital Xi'an Jiaotong University
Xi'an, China
  Connect »

Wei Zhang, Doctor

Tang-Du Hospital
Xi'an, China
  Connect »

Ying Ma, Doctor

Af liated Hospital of North Sichuan Medical College
Nanchong, China
  Connect »

Xiaoya Xu, Doctor

Zigong First People's Hospital
Zigong, China
  Connect »

Nan Zhang, Doctor

Tianjin Medical University General Hospital
Heping, China
  Connect »

Yuying Zhou, Doctor

Tianjin Huanhu Hospital
Jinnan, China
  Connect »

Xinling Meng

Traditional Chinese Medicine Hospital of Xinjiang Autonomous Region
Urumqi, China
  Connect »

Benyan Luo, Doctor

First Affiliated Hospital of Zhejiang University
Hangzhou, China
  Connect »

Peilin Lu, Doctor

Shao Yifu Hospital of Zhejiang Medical University
Hangzhou, China
  Connect »

Enyan Yu

Zhejiang Provincial People's Hospital
Hangzhou, China
  Connect »

Guomin Xie, Doctor

Ningbo City Medical Treatment Center Lihuili Hospital
Ningbo, China
  Connect »

Zhen Wang

First Affiliated Hospital of Wenzhou Medical Univeristy
Wenzhou, China
  Connect »