Last updated on April 2018

A Real-World Study of Pegylated Interferon In Nucleoside-treated Patients With Chronic Hepatitis B


Brief description of study

The aim of the prospective real-world study is to evaluate whether sequential combination therapy with pegylated interferon plus entecavir/tenofovir could induce higher rates of HBsAg loss in nucleoside-treated patients with chronic hepatitis B compared to continuous nucleoside treatment.

Detailed Study Description

Patents who were treated with NA at least one year and achieved hepatitis B virus (HBV) DNA suppression and HBsAg level<3000 international unit (IU) /mL are enrolled in this study, they are assigned into two groups, in group I, patients will receive pegylated interferon plus entecavir/tenofovir for 48/72/96 weeks, in group II, patients will receive entecavir/tenofovir for 96 weeks. HBsAg loss rates at the end of treatment and sustained response at the end of follow up will be evaluated.

Clinical Study Identifier: NCT03357822

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Junliang Fu

302 Military Hospital of China
Beijing, China
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Xinyue Chen, Doctor

BeiJing YouAn Hospital, Capital Medical University
Beijing, China
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Xuqing Zhang

The First Hospital Affiliated to AMU
Chongqing, China
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Jiaji Jiang, Doctor

The First Affiliated Hospital of Fujian Medical University
Fuzhou, China
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Qin Ning

The First Affiliated Hospital of Guangxi Medical University
Nanning, China
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Qi Xia

The First Affiliated Hospital of College of Medicine, Zhejiang University
Zhejiang, China
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Deming Tan, Doctor

Departmen of infectious disease, Xiangya Hospital, Central-south Universit
Changsha, China
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Guozhong Gong

The Second Xiangya Hospital of Central South University
Changsha, China
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Chuanlong Zhu

The First Affiliated Hospital with Nanjing Medical University
Nanjing, China
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Wei Zhao

The Second Hospital of Nanjing
Nanjing, China
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Qianguo Mao

Traditional Chinese Medicine,Xiamen Hospital
Shantou, China
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Yongping Chen, Doctor

The first affiliated hospital of Wenzhou medical universtiy
Wenzhou, China
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