Last updated on May 2018

A Study of MM-121 in Combination With Chemotherapy Versus Chemotherapy Alone in Heregulin Positive NSCLC

Brief description of study

The purpose of this study is to determine whether the combination of MM-121 plus docetaxel is more effective than docetaxel alone in regards to PFS in patients with heregulin-positive NSCLC.

Detailed Study Description

This study is a randomized, open-label, international, multi-center, phase 2 study in patients with Heregulin-positive NSCLC histologically classified as adenocarcinoma that have progressed following no more than two systemic therapies for locally advanced or metastatic disease, one of which must have been a platinum containing regimen. All patients will initially be screened for heregulin status. Eligible patients will be randomized to receive MM-121 in combination with docetaxel versus docetaxel alone.

Clinical Study Identifier: NCT02387216

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Patricia Plezia, PharmD

Tucson, AZ United States
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Jorge Nieva, MD

Los Angeles, CA United States
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Kimberly Young

Santa Rosa, CA United States
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Angela Akar

Tampa, FL United States
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Chae Young

Chicago, IL United States
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Wael Harb, MD

Lafayette, IN United States
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David Boucher

Boston, MA United States
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Gayle Calistro

Danvers, MA United States
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Haiying Cheng, MD

Bronx, NY United States
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Jennifer Hull, RN

New York, NY United States
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John Lee

Philadelphia, PA United States
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Mara Yerk

Pittsburgh, PA United States
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Karin Chocquette, RN

Fairfax, VA United States
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Leila Ponce

Seattle, WA United States
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Antonio Estacio

Toronto, ON Canada
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Nancy Herrman

Bad Berka, Germany
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Annegret Koepke

Frankfurt, Germany
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Eniko Jambor

Budapest, Hungary
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Monika Daruka

Miskolc, Hungary
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Anna Keresztesi

Tatabanya, Hungary
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Teresa Moran

Badalona, Spain
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Chouaid Christos, MD

CHI Creteil
Créteil, France
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Maurice Perol, MD

Centre L on B rard
Lyon cedex 08, France
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