Last updated on September 2017

Hippocampus Avoidance PCI vs PCI


Brief description of study

Using Intensity Modulated radiotherapy it is possible to treat the entire brain to standard dosages of whole-brain radiation, while keeping the radiation dose to the hippocampus low. However, a clear relationship between radiation dose and damage to the hippocampal stem cells has not been established yet. This study is initiated to investigate the early and delayed neurotoxicity of PCI and to assess in a randomised design the benefits and risks of sparing the hippocampus in Small Cell Lung Cancer patients who receive PCI.

Clinical Study Identifier: NCT01780675

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Jan van Meerbeeck, MD, PhD

Universitair Ziekenhuis Antwerpen
Antwerpen, Belgium
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Yolande Lievens, MD, PhD

Universitair Ziekenhuis Gent
Gent, Belgium
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Stephanie Peeters, MD, PhD

Universitair Ziekenhuis Leuven
Leuven, Belgium
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Jose Belderbos, MD, PhD

The Netherlands Cancer Institute
Amsterdam, Netherlands
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Edith Dieleman, MD, PhD

Academisch Medisch Centrum
Amsterdam, Netherlands
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Katrien de Jaeger, MD, PhD

Catharina Ziekenhuis
Eindhoven, Netherlands
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Jose Belderbos, MD, PhD

Universitair Medisch Centrum Groningen
Groningen, Netherlands
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John Praag, MD

Erasmus MC Cancer Centre
Rotterdam, Netherlands
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Friderieke Koppe, MD

Instituut Verbeeten
Tilburg, Netherlands
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