Last updated on June 2018

Assessment of Intellectual Psychological and Behavioural Developments Between 6 and 9 Years of the Children Born to Hyperthyroid Mothers During Their Pregnancy


Brief description of study

  1. MAIN OBJECTIVE :

To assess the consequences of a maternal hyperthyrod during pregnancy on intellectual development of the child from 6 to 9 years

2. SECONDARY OBJECTIVES :

  1. To assess the consequences of a maternal hyperthyrod during pregnancy on the capacities of attention, learning process and the degree of hyperactivity of the child from 6 to 9 years.
  2. To study if it exist differences of intellectual development, capacities of attention, learning process, and degree of hyperactivity in the child from 6 to 9 years, born to hyperthyroid mother during pregnancy, according to:
    • the etiology of the maternal hyperthyrod (transitory gestation hyperthyroid versus disease of Basedow),
    • the use or not of a anti-thyroid treatment,
    • the rate of TSH nonatal (measured with the blotter by tracking with J3 at all the new born ones).

Detailed Study Description

  1. INCLUSION CRITERIA :
    • Old from 6 to 9 years included
    • Age of gestation between 37 and <41 weeks of amenorrhoea
    • Born from a mono-foetale pregnancy
    • Euthyrod at the time of the entry in the study
    • Provided education for at the elementary school on a level adapted to its age 2. NON INCLUSION CRITERIA :
    • Presenting a congenital hypothyrod or a known thyroid dysfonction at the time of the entry in the study
    • Carrier of a chronic pathology (organic or psychological) or malformative severe
    • Presenting an antecedent of Deficit of the Attention-Hyperactivity to the 1st degree 3. EXCLUSION CRITERIA :
      • Discovered of a thyroid dysfonction at the time of the entry in the study 4. STRATEGIES / PROCEDURES :

Multicentric, comparative study of a troop of child born to hyperthyrod mothers during pregnancy (children exposed to the maternal hyperthyrod) and children born to euthyrod mothers during pregnancy (nonexposed children with the maternal hyperthyrod).

  • 1st part of the study: Retrospective analyze of the files of symptomatic hyperthyroid mothers during pregnancy.
  • 2nd part of the study: Assessment of intellectual development, capacities of attention, learning process and degree of hyperactivity of the children between 6 and 9 years. The exposed children (born to hyperthyrod mothers during pregnancy) will be compared with nonexposed children (born to euthyrod mothers during pregnancy).

Clinical Study Identifier: NCT01779817

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Delphine DRUI

University Hospital of Nantes
Nantes, France
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