Last updated on August 2016

Prospective Outcomes of Second-Line Therapy in Acute Graft-Versus-Host Study Including ECP (POSTAGE)

Brief description of study

This research trial studies medical chart review in determining outcomes of second-line therapy in patients with acute graft-versus-host disease previously treated with extracorporeal photopheresis or other systemic therapies. Gathering information about second-line therapy in patients with acute graft-versus-host disease may help doctors learn more about the disease and find better treatment.

Detailed Study Description

PRIMARY OBJECTIVES: I. To determine 6-month freedom from treatment failure for second-line therapy for acute graft versus host disease (aGVHD). II. To show that extracorporeal photopheresis (ECP) is associated with a superior 6 month (m) freedom from treatment failure (FFTF) as compared to other treatment modalities for second line therapy for aGVHD. III. To describe health care burden in patients receiving second line therapy for acute GVHD. IV. Quality of life measurement using Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) in patients receiving second line therapy for aGVHD. OUTLINE: Study data are collected and managed using Research Electronic Data Capture (REDCap) tools at baseline and on days 5, 28, and 56. After completion of study, patients are followed up at 6 months, and 1 and 2 years.

Clinical Study Identifier: NCT02151539

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Nandita Khera

Mayo Clinic in Arizona
Scottsdale, AZ United States
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Sunil H. Abhyankar

University of Kansas Hospital - Westwood Cancer Center
Westwood, KS United States
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Shahrukh K. Hashmi

Mayo Clinic
Rochester, MN United States
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Navneet Majhail, MD

The Cleveland Clinic
Cleveland, OH United States
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Madan H. Jagasia

Vanderbilt-Ingram Cancer Center (VICC)
Nashville, TN United States
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Hildegard Greinix

Medical University Vienna
Vienna, Austria
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Daniel Wolff

Klinikum der Universit t Regensburg
Regensburg, Germany
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Emma Das-Gupta

Nottingham City Hospital
Nottingham, United Kingdom
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