Last updated on September 2018

The Norwegian Drug Monitoring Study


Brief description of study

Infliximab and other TNF-inhibitors have revolutionised the treatment of several immunological inflammatory diseases. Still, more than half of the patients either do not respond sufficiently to infliximab therapy or loose efficacy over time. The large individual variation in the serum drug concentrations on standard doses and the development of anti-drug antibodies are thought to be main reasons for these treatment failures. An individualised treatment strategy based on systematic assessments of serum drug concentrations, therapeutic drug monitoring, has been proposed as a clinical tool to optimise efficacy of infliximab treatment. Therapeutic drug monitoring seems reasonable both from a clinical and an economical point of view, but the effectiveness of this treatment strategy still remain to be shown. The NOR-DRUM study is planned as a national, randomised controlled multicentre trial in two parts aiming to assess the effectiveness of therapeutic drug monitoring in order to achieve remission in patients with immunological inflammatory diseases starting infliximab treatment (part A) and in order to maintain disease control in patients on maintenance infliximab treatment (part B). The results of the NOR-DRUM study will hopefully contribute to an implementation of a personalised medicine approach to treatment with infliximab and other biological drugs.

Clinical Study Identifier: NCT03074656

Contact Investigators or Research Sites near you

Start Over

Kristin Kåsin Jørgensen, MD, PhD

Akershus University Hospital
Oslo, Norway
  Connect »

Geir Noraberg, MD

S rlandet Sykehus, Arendal
Arendal, Norway
  Connect »

Turid Thune, MD

Haukeland, HELSE BERGEN HF,
Bergen, Norway
  Connect »

Yngvill Bragenes, MD

Drammen, VESTRE VIKEN HF
Drammen, Norway
  Connect »

Carl Magnus Ystrøm, MD

Elverum, SYKEHUSET INNLANDET HF
Elverum, Norway
  Connect »

Roald Torp, MD

Hamar, SYKEHUSET INNLANDET HF
Hamar, Norway
  Connect »

Svanaug Skorpe, MD

HAUGESUND SANITETSFORENING revmatismesykehus
Haugesund, Norway
  Connect »

Ingrid Blomgren, MD

Haugesund Sjukehus
Haugesund, Norway
  Connect »

Brigitte Michelsen, MD

S RLANDET SYKEHUS HF Kristiansand
Kristiansand, Norway
  Connect »

Eldrid Strand

REVMATISMESYKEHUSET AS, Lillehammer
Lillehammer, Norway
  Connect »

Anne Haugen, MD, PhD

Sykehuset stfold Moss
Moss, Norway
  Connect »

Øystein Sandanger, MD, PhD

Rikshospitalet
Oslo, Norway
  Connect »

Silje W Syversen, MD, PhD

Diakonhjemmet Sykehus
Oslo, Norway
  Connect »

Camilla Zettel, MD

Betanien Hospital
Skien, Norway
  Connect »

Lars Karlsen, MD

Stavanger Universitetssjukehus
Stavanger, Norway
  Connect »

Christian Dotterud, MD

St Olavs Hospital
Trondheim, Norway
  Connect »

Rune Njålla, MD

Bod , NORDLANDSSYKEHUSET
Bodø, Norway
  Connect »

Pawel Mielnik, MD

Helse F rde Hf
Førde, Norway
  Connect »

Trude Brun, MD

Troms , UNIVERSITETSSYKEHUSET NORD-NORGE HF
Tromsø, Norway
  Connect »

Kathrine Seeberg, MD

Sykehuset Vestfold, T nsberg
Tønsberg, Norway
  Connect »

Maud Kristine Aga Ljoså, MD

lesund, HELSE M RE OG ROMSDAL HF
Ålesund, Norway
  Connect »