Last updated on February 2018

Urinary Tract Infection Due to Beta-lactamase-producing Enterobacteriaceae in Children

Brief description of study

Urinary tract infection due to Extended-spectrum beta-lactamase producing enterobacteriaceae (E-ESBL UTI) become a frequent problem. A too large variety in the prescription of antibiotics for E-ESBL UTI in children and absolute recommendations regarding the optimal treatment of E-ESBL is nearly impossible at this time.

Our aim was to describe the characteristics and treatments of urinary tract infections caused by Extended spectrum betalactamase-producing Enterobacteriaceae in children.

Detailed Study Description

In this prospective observational study between March 2013 and March 2017, children (0 to 18 years) with ESBL-E UTI were enrolled in 24 pediatric departments in France. Clinical and biological characteristics, risk factors of infection of E-ESBL, first and second lines of antibiotic therapies were analyzed. The investigators used the Kaplan-Meier method to estimate the time to fever defervescence and hospitalization duration, and Log-rank test to assess equality of survivor functions. The investigators also analyzed the resistance patterns and molecular characterization of ESBL types in the isolates.

Clinical Study Identifier: NCT02832258

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Aurélien Galerne

Jean Verdier Hospital
Bondy, France
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Christine Orzechowski

Saint Camille Hospital
Bry-sur-Marne, France
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Fouad Madhi, MD

CHI Cr teil
Créteil, France
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Irina Craiu

CHU Le Kremlin-Bic tre
Kremlin-Bicètre, France
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