Last updated on February 2018

Towards an Easy-to-use Adrenal Cancer/Tumor Identity Card


Brief description of study

Malignant pheochromocytoma/paraganglioma (MPP) and adrenocortical carcinoma (ACC) are two rare cancer entities with a very unfavorable prognosis. The knowledge on these rare cancers improved thanks to the French COMETE network originally based on two clinical centers (HEGP and Cochin) well organized for clinical and biological samples collection. Over the last 10 years, the COMETE key partners deciphered molecular mechanisms of tumorigenesis and oncogenesis of these tumors and identified molecular signatures discriminating between benign and malignant cancers by integrated genomic approaches. This strategy was highly successful in delivering new diagnostic applications of genomics technologies that now appear as potentially suitable for rapid implementation in routine clinical care.

The main objective of COMETE-TACTIC is to provide an easy-to-use "identity card" of the adrenal tumors that will allow a personalized " la carte" management of the patient and, when indicated, to the indication of the most accurate molecular targeted therapy.

We hypothesize that the improvement of MPP and ACC diagnosis and of the therapeutic options proposed to affected patients will require,

  1. the transfer to routine practice and the prospective validation of the novel diagnostic and predictive biomarkers issued from recent discoveries (genetics, genomics, histological biomarkers);
  2. the implementation of the translational research projects based on the COMETE collection to identify circulating diagnostic, prognostic and therapeutic genetic and metabolic biomarkers that could be used as non-invasive "liquid biopsies".

Detailed Study Description

Malignant pheochromocytoma/paraganglioma (MPP) and adrenocortical carcinoma (ACC) are two rare cancer entities with a very unfavorable prognosis. The knowledge on these rare cancers improved thanks to the French COMETE ('COrtex, MEdulla Tumors Endocrines') network originally based on two clinical centers (HEGP and Cochin) well organized for clinical and biological samples collection. Over the last 10 years, the COMETE key partners deciphered molecular mechanisms of tumorigenesis and oncogenesis of these tumors and identified molecular signatures discriminating between benign and malignant cancers by integrated genomic approaches. COMETE has published more than 200 papers and performed seminal work on the pathophysiology and the genetics of MPP and ACC published in high-impact journals.

This strategy was highly successful in delivering new diagnostic applications of genomics technologies that now appear as potentially suitable for rapid implementation in routine clinical care.

The main objective of COMETE-TACTIC program is to design and validate an easy-to-use "identity card" classifying MPP and ACC in clinical routine, using molecular genomic and metabolomic tools combined with histopathological-based tests, to provide a real help for early diagnosis, prognostic as well as a personalized " la carte" management and treatment to patients with malignant adrenal tumors. Seven teams, with an expertise in genomics of adrenal tumors, or in metabolomics approaches, or in clinical research and statistical analyses collaborate in COMETE-TACTIC. COMETE-TACTIC will be based on an already constituted large cohort of 850 patients that will be enlarged by the prospective enrolment of new cases and biological samples (300 to 450 new cases during the 3 years of the project) via 21 French expert and/or competence centers of COMETE-Cancer Reference center.

Previous COMETE basic studies provided important new insight for the understanding of molecular mechanisms responsible for MPP or ACC. With the transfer of "Omics"-based tests from research laboratories to clinical practice, COMETE-TACTIC is the next step toward a personalized medicine for patients with MPP and ACC. COMETE-TACTIC should speed the transfer in routine clinical care of new biomarkers based on cutting-edge technologies combining advanced pathology assessment and targeted genomics and metabolomics to diagnose malignancy and predict outcome, and thereby facilitating a more accurate, rapid and reliable diagnostic work-up for patients. This personalized management will help to avoid delayed diagnosis and to direct clinical decisions resulting in a better health outcome for the patients. COMETE-TACTIC will offer the access to a precise molecular classification of MPP and ACC that should guide targeted therapies. Finally, COMETE-TACTIC will investigate for the first time the impact of circulating biomarkers for the diagnosis and prognostic of adrenal cancers that will be further tested as biomarkers of response to targeted therapies.

Clinical Study Identifier: NCT02672020

Contact Investigators or Research Sites near you

Start Over

Sandrine LABOUREAU

CHU-Angers
Angers, France
  Connect »

Herve LEFEBVRE

CHU Rouen-Hopital de Bois-Guillaume
Bois-Guillaume, France
  Connect »

Antoine TABARIN

CHU Bordeaux, Hopital du Haut Leveque
Bordeaux, France
  Connect »

Emmanuel SONNET

CHU Brest, Hopital de la Cavale Blanche
Brest, France
  Connect »

Francoise BORSON-CHAZOT

HCL- Centre Hospitalier Lyon Est
Bron, France
  Connect »

Marie BATISSE-LIGNIER

CHU Clermont-Ferrand, Hopital Gabriel Montpied
Clermont-Ferrand, France
  Connect »

Olivier CHABRE

CHU Grenoble- Hopital Albert Michallon
Grenoble, France
  Connect »

Philippe CHANSON

Assistance Publique Hopitaux de Pais, Hopital de Bicetre
Le Kremlin Bicetre, France
  Connect »

Francoise ARCHAMBEAUD

CHU Limoges, Hopital du Cluzeau
Limoges, France
  Connect »

Flora FASSIO

CHU Montpellier, Hopital Lapeyronie
Montpellier, France
  Connect »

Delphine DRUI

CHU Nantes, Hopital La nnec
Nantes, France
  Connect »

Laurence AMAR

Assistance Publique Hopitaux de Paris -HEGP
Paris, France
  Connect »

Jerome BERTHERAT

Assistance Publique Hopitaux de Paris, Cochin
Paris, France
  Connect »

Chris OTTOLENGHI

Assistance Publique Hopitaux de Paris, Necker
Paris, France
  Connect »

Cecile GHANDER

Assistance Publique Hopitaux de Paris, Pitie Salpetriere
Paris, France
  Connect »

Benedicte DECOUDIER

CHU Reims, Hopital Robert Debre
Reims, France
  Connect »

Isabelle GUILHEM

CHU Rennes, Hopital Sud
Rennes, France
  Connect »

Bernard GOICHOT

CHU Strasbourg, Hopital de Hautepierre
Strasbourg, France
  Connect »

Philippe CARON

CHU Toulouse, IUC Oncopole
Toulouse, France
  Connect »

Peggy RENOULT-PIERRE

CHU Tours, Hopital Bretonneau
Tours, France
  Connect »

Eric BAUDIN

Institut Gustave Roussy
Villejuif, France
  Connect »