Last updated on March 2018

Effects of Inhibiting Early Inflammation in Kidney Transplant Patients


Brief description of study

During transplant surgery, there is a period of time when a donated kidney is removed from a donor's body and stored until the time of the transplant surgery. The storage procedure results in buildup of various proteins within the kidney that can injure the donated kidney after it is transplanted. One of these proteins is tumor necrosis factor-alpha (TNF-alpha).

The purpose of this study is to evaluate whether taking infliximab, which blocks TNF-alpha, just prior to transplant surgery along with usual transplant medicines will protect the donated kidney from damage caused by TNF-alpha and help keep the transplanted kidney healthy for a longer period of time.

Clinical Study Identifier: NCT02495077

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Janette Gadzhyan, MD, MS

University of California, Los Angeles
Los Angeles, CA United States
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Flavio Vincenti, MD

University of California, San Francisco
San Francisco, CA United States
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Richard Formica Jr., MD

Yale University
New Haven, CT United States
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Kenneth Newell, MD, PhD

Emory University
Atlanta, GA United States
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Randall Sung, MD

University of Michigan
Ann Arbor, MI United States
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Tarek Alhamad, MD

Washington University
Saint Louis, MO United States
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Peter Heeger, MD

Icahn School of Medicine at Mount Sinai
New York, NY United States
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Emilio Poggio, MD

Cleveland Clinic
Cleveland, OH United States
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Donald Hricik, MD

University Hospitals of Cleveland
Cleveland, OH United States
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David Rush, MD

University of Manitoba
Winnipeg, MB Canada
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Roslyn B. Mannon, MD

University of Alabama
Birmingham, AL United States
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Jonathan S. Bromberg, MD, PhD

University of Maryland
Baltimore, MD United States
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Daniel C. Brennan, MD

Johns Hopkins University
Baltimore, MD United States
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David Foley, MD

University of Wisconsin
Madison, WI United States
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Kathryn Tinckam, MD

Toronto General Hospital
Toronto, ON Canada
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