Last updated on December 2017

Study of Acarbose in Longevity (SAIL)

Brief description of study

Study of Acarbose in Longevity (SAIL)

Detailed Study Description

The goal of this study is to find out if acarbose, a medicine commonly used to treat diabetes, may have other effects in the body that could slow the aging process. Laboratory experiments have shown that mice treated with acarbose live longer. Scientists believe that acarbose may have “anti-aging” effects and could protect people from conditions like heart disease and cancer. Acarbose might do this is by changing the way genes work in the body (“gene expression”) or by changing the bacteria in the intestine.

The purpose of this study is to find out whether acarbose treatment can change “gene expression” in the muscle and fat tissue and change the bacteria in the intestine of older adults who have pre-diabetes, making them more like healthy, younger people. We will also study whether acarbose improves blood sugar levels and several heart disease risk factors.

Clinical Study Identifier: TX147911

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Gilda Trandafirescu, MD

Einstein-Montefiore Institute for Clinical and Translational Research
Bronx, NY USA
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