Last updated on June 2012

Study of Genetic and Dietary Effects on Diabetes and Heart Disease Study


Brief description of study

Study of Genetic and Dietary Effects on Diabetes and Heart Disease Study

Detailed Study Description

Fructose is a sugar consumed in large amounts by Americans. It is rapidly taken up by the liver and changed into fats called triglycerides by a process called de novo lipogeneis. Over time, increased fat in the liver and bloodstream may increase the chances of diabetes and heart disease.

As a group, people with ancestors from South Asia have high rates of heart attacks and diabetes when they move from the country to the city and eat differently. We will test whether healthy, lean South Asians make more fat from sugar compared to Caucasians who have a much lower risk of these health problems. If they do, they may especially benefit from reducing the amount of fructose in the diet.

Patient Inclusion Criteria:

  • 18-35 years old
  • South Asian or Caucasian ancestry
  • Normal weight (body mass index <25)
  • Not taking any medications or have any illnesses
  • Non-smoking

Patient Exclusion Criteria:

  • 36 years of age and older
  • Body weight index greater than 25
  • LOn Medication
  • Smoking

Clinical Study Identifier: TX136060

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Darwin Bernardez

The Rogosin Institute
New York, NY USA
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