Last updated on July 2010

Cognitive-Motor Function in Geriatric, Neurological and Psychiatric Disorders


Brief description of study

Cognitive-Motor Function in Geriatric, Neurological and Psychiatric Disorders

Detailed Study Description

The Cognitive Neurophysiology Laboratory (CNL) at Albert Einstein College of Medicine of Yeshiva University, is recruiting participants aged 18-35 and 58-70 for a study on aging, which examines the link between age, brain activity and day-to-day functioning.

Deterioration of executive control mechanisms is a prominent component of the cognitive decline seen in normal aging. Functional neuroimaging shows clear changes in activity patterns within prefrontal cortical regions during executive tasks. However, effective executive control relies on the interaction of multiple cognitive sub-processes (e.g. task-set encoding, task initiation, sustained attention, suppression of old task-sets, anticipatory activation of task-specific perceptual processing regions, inhibition of inappropriate responses, etc.). Many of these sub-functions rely on circuits involving nodes beyond the frontal lobes. The goal of this project, therefore, is to use well-established event-related potential (ERP) and functional imaging (fMRI) paradigms to assess the extent of involvement of specific executive sub-routines in geriatric cognitive decline. The second major intersecting goal of this project derives from the common observation that there is considerable variance in the severity of cognitive decline across the elderly population. Here we are interested in who ERP and fMRI-correlates that underlie successful aging.

The study will involve up to 2 visits, one visit for a screening and neuropsychological evaluation (approximately 3 hours) and a second visit for an EEG recording, a simple way to read brainwaves whilst you do a series of task experiments (approximately 4-6 hours). Compensation of $12.00 per hour is provided.

Patient Inclusion Criteria:

  • Participants aged 18-35 and 58-70.

Clinical Study Identifier: TX135017

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Danielle DeMaio

The Harold & Muriel Block Institute for Clinical and Translational Research at Einstein & Montefiore
Bronx, NY USA
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