Last updated on April 2015

Mycophenolate Mofetil in Patients With Progressive Idiopathic Membranous Nephropathy


Brief description of study

Cyclosporin decreases proteinuria and improve renal function in patients with idiopathic membranous nephropathy, but has a risk of side effects such as nephrotoxicity. The investigators plan to the study to evaluate whether mycophenolate mofetil (MMF) could be a reasonable alternative with fewer side effect.

Detailed Study Description

Idiopathic membranous nephropathy is most common cause of glomerulonephritis in adults. Persistent high grade proteinuria or progressively decrease of renal function is a risk factor for end stage renal disease in idiopathic membranous nephropathy. It has been reported that cyclosporin in patients with idiopathic membranous nephropathy decreases proteinuria and improve renal function. Mycophenolate mofetil is a recently developed immunosuppressive agent with fewer side effect than cyclosporin. In this study patients with high risk group of progressive idiopathic membranous nephropathy will be treated with mycophenolate mofetil and low dose prednisone. The outcome will be compared to controls treated with cyclosporin and low dose prednisone.

Clinical Study Identifier: NCT01282073

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Won-Suk An, MD

Dong-A University Medical Center
Busan, Korea, Republic of
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Yang-Wook Kim, MD

Inje University Haeundae Paik Hospital
Busan, Korea, Republic of
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Sun-Hee Park, MD

Kyungpook National University Hospital
Daegu, Korea, Republic of
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Duk-Hyun Lee, MD

Daegu Fatima Hospital
Daegu, Korea, Republic of
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Kyu Hyang Cho, MD

Yeungnam University Medical Center
Daegu, Korea, Republic of
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Yon Su Kim, MD

Seoul National University Hospital
Seoul, Korea, Republic of
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Tae-Hyun Yoo, MD

Yonsei University Hospital
Seoul, Korea, Republic of
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Jung Pyo Lee, MD

Boramae Medical Center
Seoul, Korea, Republic of
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Hyun-Chul Chung, MD

Ulsan University Hospital
Ulsan, Korea, Republic of
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