Last updated on September 2017

A Dose-ranging Study of the Efficacy of ESN364 in Postmenopausal Women Suffering Vasomotor Symptoms (Hot Flashes)


Brief description of study

This study is to determine the effects of different doses and dosing regimens of ESN364 on the frequency and severity of hot flashes. The treatment will be administered for 12 weeks to postmenopausal women, ages 40 to 65, suffering at least 50 moderate to severe hot flashes per week.

Detailed Study Description

Vasomotor symptoms (hot flashes) are the most common complaint among women entering menopause and, for many women, may continue to occur for up to 5 years (although about 20% of women may have them for up to 15 years). Approximately 75% of peri-menopausal women will experience vasomotor symptoms, with 10% to 20% of those enduring severe symptoms. Today, more than 25 million women in the United States alone experience symptoms of vasomotor symptoms, and 4 million women report severe symptoms. Vasomotor symptoms can have a significant negative impact on the quality of life and are therefore a major reason for menopausal women to seek medical attention. ESN364 is an orally-available and potent small molecule that has been shown to reduce the frequency of vasomotor symptoms. This study is to determine the effects of different doses and dosing regimens of ESN364 on the frequency and severity of hot flashes. The treatment will be administered for 12 weeks to postmenopausal women, ages 40 to 65, suffering at least 50 moderate to severe hot flashes per week.

Clinical Study Identifier: NCT03192176

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Steven Ramael, MD

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Birmingham, AL United States
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Steven Ramael, MD

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Phoenix, AZ United States
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Steven Ramael, MD

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Los Angeles, CA United States
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Steven Ramael, MD

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Oceanside, CA United States
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Steven Ramael, MD

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Panorama City, CA United States
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San Diego, CA United States
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Steven Ramael, MD

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Thousand Oaks, CA United States
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Steven Ramael, MD

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Denver, CO United States
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Steven Ramael, MD

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Milford, CT United States
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Steven Ramael, MD

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Crystal River, FL United States
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Steven Ramael, MD

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DeLand, FL United States
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Steven Ramael, MD

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Jupiter, FL United States
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Steven Ramael, MD

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Lake Worth, FL United States
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Steven Ramael, MD

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Miami, FL United States
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Ormond Beach, FL United States
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Steven Ramael, MD

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Port Saint Lucie, FL United States
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Steven Ramael, MD

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Norcross, GA United States
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Champaign, IL United States
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Marrero, LA United States
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Watertown, MA United States
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Lincoln, NE United States
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Norfolk, NE United States
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Las Vegas, NV United States
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Columbus, OH United States
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Mount Pleasant, SC United States
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Steven Ramael, MD

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Clarksville, TN United States
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Hurst, TX United States
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Lampasas, TX United States
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Plano, TX United States
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San Antonio, TX United States
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Vienna, VA United States
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Seattle, WA United States
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Steven Ramael, MD

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Spokane, WA United States
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