Last updated on August 2017

A Dose Escalation Phase I Study to Assess the Safety and Clinical Activity of Multiple Cancer Indications


Brief description of study

THINK (THerapeutic Immunotherapy with NKR-2) is a multinational (EU/US) open-label Phase I study to assess the safety and clinical activity of multiple administrations of autologous NKR-2 cells in seven refractory cancers, including five solid tumors (colorectal, ovarian, bladder, triple-negative breast and pancreatic cancers) and two hematological tumors (acute myeloid leukemia and multiple myeloma). The trial will test three dose levels. At each dose, the patients will receive three successive administrations, two weeks apart, NKR-2 cells. The dose escalation part of the study will enroll up to 24 patients while the extension phase would enroll 86 additional patients.

Clinical Study Identifier: NCT03018405

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Jeff Edelman

Tampa, FL United States
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Amy Whitworth

Buffalo, NY United States
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Kim Auth

Pittsburgh, PA United States
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